Kozo Ochi

Overview

Best Publications

• Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.

  Susumu Okamoto;Aki Tamaru;Chie Nakajima;Kenji Nishimura

  390
  Citations

• Structural Basis for Transcription Regulation by Alarmone ppGpp

  Irina Artsimovitch;Vsevolod Patlan;Shun-ichi Sekine;Marina N Vassylyeva

  382
  Citations

• Polyketide Synthase Gene Coupled to the Peptide Synthetase Module Involved in the Biosynthesis of the Cyclic Heptapeptide Microcystin

  Tomoyasu Nishizawa;Akiko Ueda;Munehiko Asayama;Kiyonaga Fujii

  353
  Citations

• New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

  Kozo Ochi;Takeshi Hosaka

  344
  Citations

• Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2).

  J Shima;A Hesketh;S Okamoto;S Kawamoto

  332
  Citations

• Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor.

  K Ochi

  288
  Citations

• Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

  Takeshi Hosaka;Mayumi Ohnishi-Kameyama;Hideyuki Muramatsu;Kana Murakami

  260
  Citations

• Bacilysocin, a Novel Phospholipid Antibiotic Produced by Bacillus subtilis 168

  Norimasa Tamehiro;Yoshiko Okamoto-Hosoya;Susumu Okamoto;Makoto Ubukata

  253
  Citations

• Novel detoxification of the trichothecene mycotoxin deoxynivalenol by a soil bacterium isolated by enrichment culture.

  J Shima;S Takase;Y Takahashi;Y Iwai

  211
  Citations

• From microbial differentiation to ribosome engineering.

  Kozo Ochi

  207
  Citations

• Ribosome engineering and secondary metabolite production.

  Kozo Ochi;Susumu Okamoto;Yuzuru Tozawa;Takashi Inaoka

  203
  Citations

• Identification of the bacterial alarmone guanosine 5′-diphosphate 3′-diphosphate (ppGpp) in plants

  Kosaku Takahashi;Koji Kasai;Kozo Ochi

  194
  Citations

• Novel Approach for Improving the Productivity of Antibiotic-Producing Strains by Inducing Combined Resistant Mutations

  Haifeng Hu;Kozo Ochi

  190
  Citations

• Acquisition of Certain Streptomycin-Resistant (str) Mutations Enhances Antibiotic Production in Bacteria

  Yoshiko Hosoya;Susumu Okamoto;Hideyuki Muramatsu;Kozo Ochi

  186
  Citations

• Activation of Antibiotic Biosynthesis by Specified Mutations in the rpoB Gene (Encoding the RNA Polymerase β Subunit) of Streptomyces lividans

  Haifeng Hu;Qin Zhang;Kozo Ochi

  178
  Citations

• Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

  Guojun Wang;Takeshi Hosaka;Kozo Ochi

  173
  Citations

• Initiation of Bacillus subtilis sporulation by the stringent response to partial amino acid deprivation.

  K Ochi;J C Kandala;E Freese

  172
  Citations

• Guanine nucleotides guanosine 5'-diphosphate 3'-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilis.

  Takashi Inaoka;Kosaku Takahashi;Mayumi Ohnishi-Kameyama;Mitsuru Yoshida

  170
  Citations

• Enhanced Expression of S-Adenosylmethionine Synthetase Causes Overproduction of Actinorhodin in Streptomyces coelicolor A3(2)

  Susumu Okamoto;Alexander Lezhava;Takeshi Hosaka;Yoshiko Okamoto-Hosoya

  160
  Citations

• New strategies for drug discovery: Activation of silent or weakly expressed microbial gene clusters

  Kozo Ochi

  0
  Citations