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Chemistry

D-Index
57
Citations
9425
World Ranking
11324
National Ranking
3075

Research.com Recognitions

  • 2016 - Fellow of the American Chemical Society
  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1997 - Fellow of Alfred P. Sloan Foundation

Overview

James S. Nowick is affiliated with the University of California, Irvine in the United States. Their research spans across multiple fields primarily within biochemistry, genetics, and molecular biology, with substantial contributions to medicine as well.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields of their research cover:

  • Molecular Biology
  • Physiology
  • Computational Theory and Mathematics
  • Biomaterials
  • Organic Chemistry

Their work addresses significant scientific topics such as:

  • Alzheimer's disease research and treatments
  • Computational Drug Discovery Methods
  • Chemical Synthesis and Analysis
  • Protein Structure and Dynamics
  • Supramolecular Self-Assembly in Materials
  • Click Chemistry and Applications
  • Antibiotic Resistance in Bacteria

They have contributed to various journals and publication venues, frequently publishing in:

  • The Journal of Organic Chemistry (7 publications)
  • Journal of the American Chemical Society (6 publications)
  • Biochemistry (6 publications)
  • Chemical Science (4 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)

James S. Nowick has collaborated often with several coauthors, including:

  • Adam G. Kreutzer (29 joint publications)
  • Gretchen Guaglianone (15 joint publications)
  • Michael A. Morris (10 joint publications)
  • Chelsea R. Jones (8 joint publications)
  • Chelsea Marie T. Parrocha (8 joint publications)

Their recent research papers include:

  • "Teixobactin kills bacteria by a two-pronged attack on the cell envelope" (2022, Nature)
  • "Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists" (2021, European Journal of Medicinal Chemistry)
  • "A cyclic peptide inhibitor of the SARS-CoV-2 main protease" (2021, European Journal of Medicinal Chemistry)
  • "Exploring amyloid oligomers with peptide model systems" (2021, Current Opinion in Chemical Biology)
  • "X-ray Crystallography Reveals Parallel and Antiparallel β-Sheet Dimers of a β-Hairpin Derived from Aβ16-36 that Assemble to Form Different Tetramers" (2020, ACS Chemical Neuroscience)

Throughout their career, they have received several distinctions including:

  • Fellow of the American Chemical Society (2016)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2009)
  • Fellow of Alfred P. Sloan Foundation (1997)

Best Publications

  • Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet

    Lauren E. Buchanan;Emily B. Dunkelberger;Huong Q. Tran;Pin Nan Cheng

  • Designed molecules that fold to mimic protein secondary structures

    Kimberly D Stigers;Michael J Soth;James S Nowick

  • Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

    Pin-Nan Cheng;Cong Liu;Minglei Zhao;David Eisenberg

  • Exploring β-Sheet Structure and Interactions with Chemical Model Systems

    James S. Nowick

  • Chemical Models of Protein β-Sheets

    James S. Nowick

  • Litter decay rates are determined by lignin chemistry

    Jennifer M. Talbot;Daniel J. Yelle;James Nowick;Kathleen K. Treseder

  • Molecular recognition in micelles: the roles of hydrogen bonding and hydrophobicity in adenine-thymine base-pairing in SDS micelles

    James S. Nowick;Jenny S. Chen;Glenn Noronha

  • The Supramolecular Chemistry of β-Sheets

    Pin-Nan Cheng;Johnny D. Pham;James S. Nowick

  • Kinetic studies and modeling of a self-replicating system

    James S. Nowick;Qing Feng;Tjama Tjivikua;Pablo Ballester

  • An improved method for the synthesis of enantiomerically pure amino acid ester isocyanates

    James S. Nowick;Noel A. Powell;Tram M. Nguyen;Glenn Noronha

  • Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

    Cong Liu;Minglei Zhao;Lin Jiang;Pin-Nan Cheng

  • An Unnatural Amino Acid that Mimics a Tripeptide β-Strand and Forms β-Sheetlike Hydrogen-Bonded Dimers

    James S. Nowick;De Michael Chung;Kalyani Maitra;Santanu Maitra

  • Novel RNA catalysts for the Michael reaction.

    Gerhard Sengle;Alexander Eisenführ;Paramjit S Arora;James S Nowick

  • Synthesis of Peptide Isocyanates and Isothiocyanates.

    James S. Nowick;Darren L. Holmes;Glenn Noronha;Eric M. Smith

  • Macrocyclic β-Sheet Peptides That Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

    Jing Zheng;Cong Liu;Michael R. Sawaya;Balraju Vadla

  • Convergent functional groups. 9. Complexation in new molecular clefts

    James S. Nowick;Pablo Ballester;Frank Ebmeyer;Julius Rebek

  • Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer’s Disease and other Amyloid Diseases

    Adam G. Kreutzer;James S. Nowick

  • Artificial β-sheets

    James S. Nowick;Eric M. Smith;Mason Pairish

  • An Artificial β-Sheet Comprising a Molecular Scaffold, a β-Strand Mimic, and a Peptide Strand1

    James S. Nowick;Darren L. Holmes;Gilbert Mackin;Glenn Noronha

  • A PRACTICAL AND EFFICIENT METHOD FOR THE SYNTHESIS OF BETA -LACTONES

    Rick L. Danheiser;James S. Nowick

Frequent Co-Authors

Joseph W. Ziller
Joseph W. Ziller University of California, Irvine
David Eisenberg
David Eisenberg Harvard University
Julius Rebek
Julius Rebek Scripps Research Institute
Michael R. Sawaya
Michael R. Sawaya University of California, Los Angeles
Borries Demeler
Borries Demeler University of Lethbridge
Charles G. Glabe
Charles G. Glabe University of California, Irvine
Pablo Ballester
Pablo Ballester Institució Catalana de Recerca i Estudis Avançats
Michael Famulok
Michael Famulok University of Bonn
Kit S. Lam
Kit S. Lam University of California, Davis

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