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Isao Nagaoka

Isao Nagaoka

Juntendo University
Japan

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
14957
World Ranking
9651
National Ranking
646

Isao Nagaoka publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Isao Nagaoka sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 339 publications — 84th percentile

84% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Isao Nagaoka D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Isao Nagaoka sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 64 D-Index — 52nd percentile

52% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Isao Nagaoka is affiliated with Juntendo University in Japan and has a research focus primarily in the field of Medicine, with a particular emphasis on immunology, epidemiology, physiology, microbiology, and molecular biology. Their work covers a range of topics including antimicrobial peptides and activities, immune response and inflammation, sepsis diagnosis and treatment, gut microbiota and health, mechanisms involving neutrophils and oxidative processes, neonatal and maternal infections, as well as nutritional studies and diet.

Nagaoka's recent scholarly contributions include the following papers:

  • "Therapeutic Potential of Cathelicidin Peptide LL-37, an Antimicrobial Agent, in a Murine Sepsis Model," 2020, International Journal of Molecular Sciences
  • "Recent advances in the research and management of sepsis-associated DIC," 2021, International Journal of Hematology
  • "Lipopolysaccharides and Cellular Senescence: Involvement in Atherosclerosis," 2022, International Journal of Molecular Sciences
  • "Outstanding Contributions of LAL Technology to Pharmaceutical and Medical Science: Review of Methods, Progress, Challenges, and Future Perspectives in Early Detection and Management of Bacterial Infections and Invasive Fungal Diseases," 2021, Biomedicines
  • "Prevention of Metabolic Syndrome by Phytochemicals and Vitamin D," 2023, International Journal of Molecular Sciences

Frequent co-authors collaborating with Nagaoka include:

  • Toshiaki Iba
  • Machiko Hatsuda
  • Yuko Fujio
  • Masami Goto
  • Kazuo Kaneko

Nagaoka has published extensively in several scientific journals, with multiple works appearing in the following venues:

  • Juntendo Medical Journal
  • International Journal of Molecular Sciences
  • Endocrine Metabolic & Immune Disorders - Drug Targets
  • Experimental and Therapeutic Medicine
  • Bioscience Biotechnology and Biochemistry

Best Publications

  • Antimicrobial Peptides Human β-Defensins Stimulate Epidermal Keratinocyte Migration, Proliferation and Production of Proinflammatory Cytokines and Chemokines

    François Niyonsaba;Hiroko Ushio;Nobuhiro Nakano;William Ng

  • A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis.

    François Niyonsaba;Kazuhisa Iwabuchi;Akimasa Someya;Michimasa Hirata

  • Evaluation of the effects of peptide antibiotics human β-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells

    François Niyonsaba;Akimasa Someya;Michimasa Hirata;Hideoki Ogawa

  • mRNA Expression of Growth Factors in Glomeruli From Diabetic Rats

    Tsukasa Nakamura;Mitsumine Fukui;Isao Ebihara;Shiori Osada

  • Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells.

    Isao Nagaoka;Satoko Hirota;François Niyonsaba;Michimasa Hirata

  • An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7

    Isao Nagaoka;Hiroshi Tamura;Michimasa Hirata

  • Human β‐defensin‐2 functions as a chemotactic agent for tumour necrosis factor‐α‐treated human neutrophils

    François Niyonsaba;Hideoki Ogawa;Isao Nagaoka

  • The human β-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes

    François Niyonsaba;Hiroko Ushio;Isao Nagaoka;Ko Okumura

  • Antimicrobial Peptides Human β-Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells

    François Niyonsaba;Hiroko Ushio;Mutsuko Hara;Hidenori Yokoi

  • Epithelial cell-derived human β-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway

    François Niyonsaba;Kazuhisa Iwabuchi;Hiroshi Matsuda;Hideoki Ogawa

  • Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli

    Xuejun Chen;François Niyonsaba;Hiroko Ushio;Daiju Okuda

  • Synergistic actions of antibacterial neutrophil defensins and cathelicidins.

    I. Nagaoka;S. Hirota;S. Yomogida;A. Ohwada

  • Modulation of Human β-Defensin-2 Transcription in Pulmonary Epithelial Cells by Lipopolysaccharide-Stimulated Mononuclear Phagocytes Via Proinflammatory Cytokine Production

    Yuko Tsutsumi-Ishii;Isao Nagaoka

  • Augmentation of the Lipopolysaccharide-Neutralizing Activities of Human Cathelicidin CAP18/LL-37-Derived Antimicrobial Peptides by Replacement with Hydrophobic and Cationic Amino Acid Residues

    Isao Nagaoka;Satoko Hirota;François Niyonsaba;Michimasa Hirata

  • Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells

    Yoko Tabe;Linhua Jin;Yuko Tsutsumi-Ishii;Yuanyuan Xu

  • Cathelicidin LL‐37 induces the generation of reactive oxygen species and release of human α‐defensins from neutrophils

    Y. Zheng;F. Niyonsaba;H. Ushio;I. Nagaoka

  • Antimicrobial peptides human β‐defensin (hBD)‐3 and hBD‐4 activate mast cells and increase skin vascular permeability

    Xuejun Chen;François Niyonsaba;Hiroko Ushio;Mutsuko Hara

  • Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis

    I Nagaoka;B C Trapnell;R G Crystal

  • NF-κB-mediated transcriptional regulation of human β-defensin-2 gene following lipopolysaccharide stimulation

    Yuko Tsutsumi-Ishii;Isao Nagaoka

  • Lactosylceramide-enriched glycosphingolipid signaling domain mediates superoxide generation from human neutrophils

    Kazuhisa Iwabuchi;Isao Nagaoka

Frequent Co-Authors

Hideoki Ogawa
Hideoki Ogawa Juntendo University
Hiroshi Tamura
Hiroshi Tamura Juntendo University
Ko Okumura
Ko Okumura Juntendo University
Hideyo Yamaguchi
Hideyo Yamaguchi Teikyo University
Yasuhiko Tomino
Yasuhiko Tomino Juntendo University
Michael Andreeff
Michael Andreeff The University of Texas MD Anderson Cancer Center
Marina Konopleva
Marina Konopleva The University of Texas MD Anderson Cancer Center
Shigaku Ikeda
Shigaku Ikeda Juntendo University
Keiichi Hiramatsu
Keiichi Hiramatsu Juntendo University
Jerrold H. Levy
Jerrold H. Levy Duke University

External Links

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Best Scientists Citing Isao Nagaoka

Robert E. W. Hancock

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Publications: 72

Richard L. Gallo

Richard L. Gallo

University of California, San Diego

Publications: 51

Hideoki Ogawa

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Juntendo University

Publications: 41

Marina Konopleva

Marina Konopleva

The University of Texas MD Anderson Cancer Center

Publications: 30

Donald J. Davidson

Donald J. Davidson

University of Edinburgh

Publications: 29

Pieter S. Hiemstra

Pieter S. Hiemstra

Leiden University Medical Center

Publications: 26

Michael Andreeff

Michael Andreeff

The University of Texas MD Anderson Cancer Center

Publications: 25

Toshihide Kobayashi

Toshihide Kobayashi

University of Strasbourg

Publications: 24

Ko Okumura

Ko Okumura

Juntendo University

Publications: 24

Octavio L. Franco

Octavio L. Franco

Universidade Católica de Brasília

Publications: 19

Fuad N. Ziyadeh

Fuad N. Ziyadeh

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Publications: 18

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Publications: 17

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Alessandro Prinetti

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Publications: 17

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