What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Internal medicine
His primary areas of study are Cell biology, Cathelicidin, Innate immune system, Antimicrobial peptides and Microbiology.
His Cell biology research is multidisciplinary, relying on both Mast cell, Inflammation, Proinflammatory cytokine and Bone marrow.
His Cathelicidin study combines topics in areas such as Rectum, Adverse effect and Saline.
His study looks at the intersection of Innate immune system and topics like MAPK/ERK pathway with Reactive oxygen species.
Isao Nagaoka interconnects Chemokine, Secretion and Cytokine in the investigation of issues within Antimicrobial peptides.
His studies deal with areas such as Antibacterial activity, Escherichia coli and Staphylococcus aureus as well as Microbiology.
His most cited work include:
- Antimicrobial Peptides Human β-Defensins Stimulate Epidermal Keratinocyte Migration, Proliferation and Production of Proinflammatory Cytokines and Chemokines (383 citations)
- A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis. (339 citations)
- Evaluation of the effects of peptide antibiotics human β-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells (296 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in Internal medicine, Biochemistry, Molecular biology, Cell biology and Endocrinology.
His research investigates the link between Molecular biology and topics such as Messenger RNA that cross with problems in Growth factor and Platelet-derived growth factor receptor.
His work carried out in the field of Cell biology brings together such families of science as Inflammation, Apoptosis, Cathelicidin, Antimicrobial peptides and Degranulation.
The concepts of his Inflammation study are interwoven with issues in Chemotaxis and Pharmacology.
In his research on the topic of Cathelicidin, Sepsis is strongly related with Lipopolysaccharide.
His work focuses on many connections between Antimicrobial peptides and other disciplines, such as Innate immune system, that overlap with his field of interest in Microbiology.
He most often published in these fields:
- Internal medicine (29.11%)
- Biochemistry (20.89%)
- Molecular biology (19.18%)
What were the highlights of his more recent work (between 2013-2021)?
- Internal medicine (29.11%)
- Endocrinology (15.07%)
- Sepsis (6.51%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Internal medicine, Endocrinology, Sepsis, Immunology and Glucosamine.
In general Internal medicine study, his work on Adverse effect, Type II collagen and Chemotherapy often relates to the realm of Cartilage metabolism, thereby connecting several areas of interest.
His studies in Sepsis integrate themes in fields like Antithrombin, Lipopolysaccharide, Microbiology, Microcirculation and Peptide.
His Glucosamine research incorporates elements of Synovial Cell, Athletes, Pharmacology and Cell biology.
He combines subjects such as Inflammation and Phosphorylation with his study of Synovial Cell.
Isao Nagaoka does research in Cell biology, focusing on Extracellular specifically.
Between 2013 and 2021, his most popular works were:
- Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism. (68 citations)
- Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells. (65 citations)
- Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction (43 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Enzyme
- Internal medicine
Isao Nagaoka spends much of his time researching Immunology, Internal medicine, Lipopolysaccharide, Pharmacology and Endocrinology.
His research integrates issues of Osteocalcin and Oncology in his study of Internal medicine.
His Lipopolysaccharide study also includes fields such as
- Programmed cell death that connect with fields like Proteases, Recombinant DNA, Annexin and Neutrophil extracellular traps,
- Cytokine, which have a strong connection to Chemokine, Tumor necrosis factor alpha, Antimicrobial peptides and Caspase 1.
Isao Nagaoka has researched Proteases in several fields, including Inflammation and Cell biology.
His biological study spans a wide range of topics, including Histone H3, Functional food, Glucosamine and MAPK/ERK pathway.
His work in Endocrinology tackles topics such as Type II collagen which are related to areas like Anterior cruciate ligament and Matrix metalloproteinase.
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