Isao Nagaoka

Overview

Best Publications

• Antimicrobial Peptides Human β-Defensins Stimulate Epidermal Keratinocyte Migration, Proliferation and Production of Proinflammatory Cytokines and Chemokines

  François Niyonsaba;Hiroko Ushio;Nobuhiro Nakano;William Ng

  720
  Citations

• A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis.

  François Niyonsaba;Kazuhisa Iwabuchi;Akimasa Someya;Michimasa Hirata

  564
  Citations

• Evaluation of the effects of peptide antibiotics human β-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells

  François Niyonsaba;Akimasa Someya;Michimasa Hirata;Hideoki Ogawa

  479
  Citations

• mRNA Expression of Growth Factors in Glomeruli From Diabetic Rats

  Tsukasa Nakamura;Mitsumine Fukui;Isao Ebihara;Shiori Osada

  431
  Citations

• Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells.

  Isao Nagaoka;Satoko Hirota;François Niyonsaba;Michimasa Hirata

  365
  Citations

• An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7

  Isao Nagaoka;Hiroshi Tamura;Michimasa Hirata

  353
  Citations

• Human β‐defensin‐2 functions as a chemotactic agent for tumour necrosis factor‐α‐treated human neutrophils

  François Niyonsaba;Hideoki Ogawa;Isao Nagaoka

  350
  Citations

• The human β-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes

  François Niyonsaba;Hiroko Ushio;Isao Nagaoka;Ko Okumura

  334
  Citations

• Antimicrobial Peptides Human β-Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells

  François Niyonsaba;Hiroko Ushio;Mutsuko Hara;Hidenori Yokoi

  331
  Citations

• Epithelial cell-derived human β-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway

  François Niyonsaba;Kazuhisa Iwabuchi;Hiroshi Matsuda;Hideoki Ogawa

  326
  Citations

• Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli

  Xuejun Chen;François Niyonsaba;Hiroko Ushio;Daiju Okuda

  285
  Citations

• Synergistic actions of antibacterial neutrophil defensins and cathelicidins.

  I. Nagaoka;S. Hirota;S. Yomogida;A. Ohwada

  257
  Citations

• Modulation of Human β-Defensin-2 Transcription in Pulmonary Epithelial Cells by Lipopolysaccharide-Stimulated Mononuclear Phagocytes Via Proinflammatory Cytokine Production

  Yuko Tsutsumi-Ishii;Isao Nagaoka

  251
  Citations

• Augmentation of the Lipopolysaccharide-Neutralizing Activities of Human Cathelicidin CAP18/LL-37-Derived Antimicrobial Peptides by Replacement with Hydrophobic and Cationic Amino Acid Residues

  Isao Nagaoka;Satoko Hirota;François Niyonsaba;Michimasa Hirata

  235
  Citations

• Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells

  Yoko Tabe;Linhua Jin;Yuko Tsutsumi-Ishii;Yuanyuan Xu

  225
  Citations

• Cathelicidin LL‐37 induces the generation of reactive oxygen species and release of human α‐defensins from neutrophils

  Y. Zheng;F. Niyonsaba;H. Ushio;I. Nagaoka

  223
  Citations

• Antimicrobial peptides human β‐defensin (hBD)‐3 and hBD‐4 activate mast cells and increase skin vascular permeability

  Xuejun Chen;François Niyonsaba;Hiroko Ushio;Mutsuko Hara

  219
  Citations

• Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis

  I Nagaoka;B C Trapnell;R G Crystal

  210
  Citations

• NF-κB-mediated transcriptional regulation of human β-defensin-2 gene following lipopolysaccharide stimulation

  Yuko Tsutsumi-Ishii;Isao Nagaoka

  177
  Citations

• Lactosylceramide-enriched glycosphingolipid signaling domain mediates superoxide generation from human neutrophils

  Kazuhisa Iwabuchi;Isao Nagaoka

  174
  Citations