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Biology and Biochemistry

D-Index
54
Citations
12639
World Ranking
15494
National Ranking
6467

Overview

Irene Orlow is affiliated with the Memorial Sloan Kettering Cancer Center in the United States and has contributed extensively to the fields of Medicine, Biochemistry, Genetics, and Molecular Biology. Their publication record indicates a strong focus on Oncology, Molecular Biology, Pulmonary and Respiratory Medicine, Genetics, and Cancer Research.

The main research topics that Irene Orlow has worked on include:

  • Cutaneous Melanoma Detection and Management
  • Melanoma and MAPK Pathways
  • Immunotherapy and Immune Responses
  • Skin Protection and Aging
  • Cancer Immunotherapy and Biomarkers
  • Cancer-related cognitive impairment studies
  • Vitamin D Research Studies

Recent publications authored or co-authored by Orlow cover a range of subjects related to cancer biology and epidemiology, including:

  • "The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders," 2021, Mutation Research/Reviews in Mutation Research
  • "DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death," 2021, Scientific Reports
  • "Coronary Artery Disease in Young Women After Radiation Therapy for Breast Cancer," 2021, JACC CardioOncology
  • "Comparison of Clinicopathologic Features and Survival of Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based Study," 2020, UNC Libraries
  • "Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus," 2021, Human Genetics

Frequently collaborating researchers with Irene Orlow include Marianne Berwick, Nancy E. Thomas, Colin B. Begg, Klaus J. Busam, and Anne Ε. Cust, each contributing to multiple projects and publications.

The venues where Orlow most commonly publishes are:

  • UNC Libraries
  • Cancer Epidemiology Biomarkers & Prevention
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Investigative Dermatology
  • Harvard Dataverse

This combination of institutional affiliation, research topics, coauthors, and publication venues illustrates a multidisciplinary approach to analyzing cancer biology, genetics, and clinical outcomes, with a particular emphasis on melanoma and related immunological factors.

Best Publications

  • The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

    Jason Pomerantz;Nicole Schreiber-Agus;Nanette J. Liégeois;Adam Silverman

  • Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

    Ganna Chornokur;Hui-Yi Lin;Jonathan P. Tyrer;Kate Lawrenson

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta

    Shalini Mathias;Anas Younes;Chu-Cheng Kan;Irene Orlow

  • GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

    Paul D.P. Pharoah;Ya Yu Tsai;Susan J. Ramus;Catherine M. Phelan

  • Tumor-Infiltrating Lymphocyte Grade in Primary Melanomas Is Independently Associated With Melanoma-Specific Survival in the Population-Based Genes, Environment and Melanoma Study

    Nancy E. Thomas;Klaus J. Busam;Lynn From;Anne Kricker

  • Lifetime Risk of Melanoma in CDKN2A Mutation Carriers in a Population-Based Sample

    Colin B. Begg;Irene Orlow;Amanda J. Hummer;Bruce K. Armstrong

  • Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

    Erica J Childs;Evelina Mocci;Daniele Campa;Daniele Campa;Paige M Bracci

  • Deletion of the p16 and p15 Genes in Human Bladder Tumors

    Irene Orlow;Louis Lacombe;Gregory J. Hannon;Manuel Serrano

  • Altered patterns of MDM2 and TP53 expression in human bladder cancer

    Pilar Lianes;Irene Orlow;Zuo-Feng Zhang;Maria R. Oliva

  • Identification of nine new susceptibility loci for endometrial cancer

    Tracy A. O'Mara;Dylan M. Glubb;Frédéric Amant;Daniela Annibali

  • Previous Lung Diseases and Lung Cancer Risk: A Pooled Analysis From the International Lung Cancer Consortium

    Darren R. Brenner;Paolo Boffetta;Eric J. Duell;Heike Bickeböller

  • Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

    Alison P. Klein;Brian M. Wolpin;Harvey A. Risch;Rachael Z. Stolzenberg-Solomon

  • Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium

    Michele L. Coté;Mei Liu;Stefano Bonassi;Monica Neri

  • Chromosome 9 Allelic Losses and Microsatellite Alterations in Human Bladder Tumors

    Irene Orlow;Pilar Lianes;Louis Lacombe;Guido Dalbagni

  • Deletions of the INK4A Gene Occur in Malignant Peripheral Nerve Sheath Tumors but not in Neurofibromas

    Helen P. Kourea;Irene Orlow;Bernd W. Scheithauer;Carlos Cordon-Cardo

  • Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma.

    Nancy E. Thomas;Sharon N. Edmiston;Audrey Alexander;Pamela A. Groben

  • Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium

    Li Rita Zhang;Hal Morgenstern;Sander Greenland;Shen Chih Chang

  • Genomic and Mutational Profiling to Assess Clonal Relationships Between Multiple Non–Small Cell Lung Cancers

    Nicolas Girard;Irina Ostrovnaya;Christopher Lau;Bernard Park

  • Genetic Evidence in Melanoma and Bladder Cancers that p16 and p53 Function in Separate Pathways of Tumor Suppression

    Nelleke A. Gruis;Jane Weaver-Feldhaus;Qingyun Liu;Cheryl Frye

Frequent Co-Authors

Marianne Berwick
Marianne Berwick University of New Mexico
Graham G. Giles
Graham G. Giles University of Melbourne
Hoda Anton-Culver
Hoda Anton-Culver University of California, Irvine
Colin B. Begg
Colin B. Begg Memorial Sloan Kettering Cancer Center
Peter A. Fasching
Peter A. Fasching University of Erlangen-Nuremberg
Ian G. Campbell
Ian G. Campbell Peter MacCallum Cancer Centre
Harvey A. Risch
Harvey A. Risch Yale University
Stephen B. Gruber
Stephen B. Gruber City Of Hope National Medical Center
Jennifer A. Doherty
Jennifer A. Doherty University of Utah
Angela Brooks-Wilson
Angela Brooks-Wilson Simon Fraser University

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