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Neuroscience

D-Index
51
Citations
10279
World Ranking
5510
National Ranking
449

Overview

Iain P. Chessell is affiliated with AstraZeneca in the United Kingdom and focuses on research within the field of Medicine. Their work spans several subfields including Physiology, Psychiatry and Mental Health, Molecular Biology, Sensory Systems, and Neurology.

The scientist's research topics encompass a variety of areas with an emphasis on mechanisms and treatments related to neurological and sensory conditions. Key topics include:

  • Pain Mechanisms and Treatments
  • Migraine and Headache Studies
  • Ion Channels and Receptors
  • Nicotinic Acetylcholine Receptors Study
  • Gastrointestinal Motility and Disorders
  • Parkinson's Disease Mechanisms and Treatments
  • Neurological Disorders and Treatments

Their research is represented in frequent publication venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cephalalgia
  • European Journal of Epidemiology
  • Cell Reports Medicine
  • The Journal of Physiology

Among recent papers authored or co-authored by Iain P. Chessell are:

  • The Dementias Platform UK (DPUK) Data Portal, 2020, European Journal of Epidemiology
  • A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain, 2020, Cephalalgia
  • Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine, 2020, Cephalalgia
  • Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice, 2023, Cell Reports Medicine
  • Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity, 2022, The Journal of Physiology

Iain P. Chessell has collaborated frequently with several researchers, including:

  • Fraser Welsh
  • James P. Higham
  • Luke A. Pattison
  • Ewan St. John Smith
  • David C. Bulmer

Best Publications

  • Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

    Iain P. Chessell;Jonathan P. Hatcher;Chas Bountra;Anton D. Michel

  • Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

    Lauriane Ulmann;Jon P. Hatcher;Jane P. Hughes;Séverine Chaumont

  • COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord

    Yiangos Yiangou;Paul Facer;Pascal F Durrenberger;Iain P. Chessell

  • Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients.

    Stephen E. Gwilym;John R. Keltner;Catherine E. Warnaby;Andrew J. Carr

  • The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity

    Fumimasa Amaya;Haibin Wang;Michael Costigan;Andrew J. Allchorne

  • The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

    Penny C. Staton;Jon P. Hatcher;Deborah J. Walker;Alastair D. Morrison

  • Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score

    Zehra Yilmaz;Tara Renton;Y Yiangou;J Zakrzewska

  • Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

    Paul Facer;Maria A Casula;Graham D Smith;Christopher D Benham

  • An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients.

    Petra Schweinhardt;Chris Glynn;Jonathan C. W. Brooks;Jonathan C. W. Brooks;Henry McQuay

  • Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain.

    Iain T. Strickland;Jo C. Martindale;Peter L. Woodhams;Alison J. Reeve

  • TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.

    Peter Thornton;Jean Sevalle;Michael J Deery;Graham Fraser

  • Localization and Functional Expression of Splice Variants of the P2X 2 Receptor

    Joseph Simon;Emma J Kidd;Fiona M Smith;Iain P Chessell

  • TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons.

    U. Anand;W.R. Otto;P. Facer;N. Zebda

  • Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.

    Uma Anand;William R. Otto;Daniel Sanchez-Herrera;Paul Facer

  • GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.

    Jorge De Alba;Nick M. Clayton;Sue D. Collins;Philip Colthup

  • Investigation into the neural correlates of emotional augmentation of clinical pain

    Petra Schweinhardt;Petra Schweinhardt;Nicola Kalk;Karolina Wartolowska;Iain Chessell

  • Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.

    Gerard M. P. Giblin;Celestine T. O'Shaughnessy;Alan Naylor;William L. Mitchell

  • Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.

    Pascal F Durrenberger;Paul Facer;Maria A Casula;Yiangos Yiangou

  • Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain

    Stephen J. Medhurst;Sue D. Collins;Andy Billinton;Sharon Bingham

  • P2X7 receptors on microglial cells mediate injury to cortical neurons in vitro

    Stephen D. Skaper;Laura Facci;Ainsley A. Culbert;Nicholas A. Evans

  • Attenuation of experimental arthritis in TRPV1R knockout mice.

    N J Barton;D S McQueen;D Thomson;S D Gauldie

Frequent Co-Authors

Irene Tracey
Irene Tracey University of Oxford
Petra Schweinhardt
Petra Schweinhardt University of Zurich
Jill C. Richardson
Jill C. Richardson MSD (United Kingdom)
Jonathan C W Brooks
Jonathan C W Brooks University of Bristol
Michael Costigan
Michael Costigan Boston Children's Hospital
Michael J. Rowan
Michael J. Rowan Trinity College Dublin

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