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Huub A. M. Middelkoop

Huub A. M. Middelkoop

D-Index & Metrics

Psychology

D-Index
49
Citations
8331
World Ranking
5732
National Ranking
271

Overview

Huub A. M. Middelkoop is a researcher affiliated with Leiden University in the Netherlands, focusing primarily on the field of medicine. Their work spans several subfields including neurology, rheumatology, pathology and forensic medicine, psychiatry and mental health, and artificial intelligence.

The main topics of Middelkoop's research include systemic lupus erythematosus, multiple sclerosis research studies, dementia and cognitive impairment research, neurological disorders and treatments, Parkinson's disease mechanisms and treatments, machine learning in healthcare, and fibromyalgia and chronic fatigue syndrome research.

Some of their recent papers are:

  • "Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease," 2021, Data Archiving and Networked Services (DANS)
  • "The Association Between Biomarkers and Neuropsychiatric Symptoms Across the Alzheimer's Disease Spectrum," 2020, American Journal of Geriatric Psychiatry
  • "Machine learning for automated EEG-based biomarkers of cognitive impairment during Deep Brain Stimulation screening in patients with Parkinson's Disease," 2021, Clinical Neurophysiology
  • "Fatigue in patients with systemic lupus erythematosus and neuropsychiatric symptoms is associated with anxiety and depression rather than inflammatory disease activity," 2021, Lupus
  • "Mortality in patients with systemic lupus erythematosus and neuropsychiatric involvement: A retrospective analysis from a tertiary referral center in the Netherlands," 2020, Lupus

Middelkoop frequently publishes in venues including Annals of the Rheumatic Diseases, Lupus, Lupus Science & Medicine, Journal of Parkinson's Disease, and IBRO Neuroscience Reports.

Their collaborations include coauthors such as Rory C. Monahan, M. Kloppenburg, T. Huizinga, Gisela M. Terwindt, and Gerda M. Steup-Beekman.

The combination of neurology and rheumatology expertise alongside the application of machine learning techniques, as seen in their papers, illustrates a multidisciplinary approach to studying neurological and autoimmune diseases.

Best Publications

  • Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study.

    L. W. de Jong;K. van der Hiele;I. M. Veer;J. J. Houwing

  • Subjective Sleep Characteristics of 1,485 Males and Females Aged 50–93: Effects of Sex and Age, and Factors Related to Self-Evaluated Quality of Sleep

    H. A. M. Middelkoop;D. A. Smilde-Van Den Doel;A. K. Neven;H. A. C. Kamphuisen

  • Assessment of cognition in Parkinson’s disease

    J. Marinus;M. Visser;N. A. Verwey;F. R.J. Verhey

  • Cognitive impairment in Parkinson’s disease

    D Verbaan;J Marinus;M Visser;S M van Rooden

  • Structural Brain Changes in Migraine

    Inge H. Palm-Meinders;Hille Koppen;Gisela M. Terwindt;Lenore J. Launer

  • Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes.

    Wiesje M van der Flier;Mark A van Buchem;Annelies W E Weverling-Rijnsburger;Elisabeth R Mutsaers

  • EEG correlates in the spectrum of cognitive decline

    K. van der Hiele;K. van der Hiele;A.A. Vein;R.H.A.M. Reijntjes;R.G.J. Westendorp

  • Sleep Disruption in Parkinson's Disease Assessment by Continuous Activity Monitoring

    B. Van Hilten;J. I. Hoff;H. A. M. Middelkoop;E. A. Van Der Velde

  • Magnetization transfer imaging in normal aging, mild cognitive impairment, and Alzheimer's disease

    Wiesje M. Van Der Flier;Dominique M. J. Van Den Heuvel;Annelies W. E. Weverling-Rijnsburger;Eduard L. E. M. Bollen

  • Increased functional connectivity and brain atrophy in elderly with subjective memory complaints.

    Anne Hafkemeijer;Irmhild Altmann-Schneider;Anna M. Oleksik;Lotte van de Wiel

  • Subtle cognitive impairments in patients with long-term cure of Cushing's disease.

    Jitske Tiemensma;Nieke E. Kokshoorn;Nienke R. Biermasz;Bart-Jan S. A. Keijser

  • Increased Prevalence of Psychopathology and Maladaptive Personality Traits after Long-Term Cure of Cushing’s Disease

    Jitske Tiemensma;Nienke R. Biermasz;Huub A. M. Middelkoop;Roos C. van der Mast

  • Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning—the DANTE Study Leiden: A Randomized Clinical Trial

    Justine E. F. Moonen;Jessica C. Foster-Dingley;Wouter de Ruijter;Jeroen van der Grond

  • Lacunar Infarcts Are the Main Correlate With Cognitive Dysfunction in CADASIL

    Michael K. Liem;Jeroen van der Grond;Joost Haan;Rivka van den Boom

  • The effect of stimulants on nocturnal motor activity and sleep quality in adults with ADHD: an open-label case-control study.

    Kooij Jj;Middelkoop Ha;van Gils K;Buitelaar Jk

  • Mortality in neuropsychiatric systemic lupus erythematosus (NPSLE)

    E J M Zirkzee;T W J Huizinga;E L E M Bollen;M A van Buchem

  • Diurnal effects of motor activity and fatigue in Parkinson's disease.

    J. J. Van Hilten;G. Hoogland;E. A. Van Der Velde;H. A. M. Middelkoop

  • 45-hour continuous quintuple-site actimetry: relations between trunk and limb movements and effects of circadian sleep-wake rhythmicity.

    H. A. M. Middelkoop;E. M. Van Dam;D. A. Smilde-Van Den Doel;G. Van Dijk

  • Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI.

    H.A.M. Middelkoop;W.M. van der Flier;E.J. Burton;A. J. Lloyd

  • MRI correlates of cognitive decline in CADASIL: a 7-year follow-up study.

    M. K. Liem;S.A.J. Lesnik Oberstein;J. Haan;I. L. van der Neut

Frequent Co-Authors

Wiesje M. van der Flier
Wiesje M. van der Flier Vrije Universiteit Amsterdam
Nic J.A. van der Wee
Nic J.A. van der Wee Leiden University Medical Center
Pauline Aalten
Pauline Aalten Maastricht University
Jordi Peña-Casanova
Jordi Peña-Casanova Autonomous University of Barcelona

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