World's Best Scientists 2026 revealed!
Hitoshi Okamoto

Hitoshi Okamoto

D-Index & Metrics

Neuroscience

D-Index
64
Citations
12434
World Ranking
3314
National Ranking
90

Biology and Biochemistry

D-Index
64
Citations
12544
World Ranking
9818
National Ranking
659

Overview

Hitoshi Okamoto is affiliated with RIKEN in Japan and has produced extensive research primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Neuroscience.

Their research focuses broadly on several key areas including Zebrafish Biomedical Research Applications, Neural dynamics and brain function, Congenital heart defects research, Sleep and Wakefulness Research, Memory and Neural Mechanisms, Regulation of Appetite and Obesity, and Turtle Biology and Conservation.

They have contributed to numerous scientific publications with frequent appearances in these venues:

  • Cell Reports
  • Current Biology
  • Archives of Toxicology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)

Their published research includes work in molecular and cellular biology, as evidenced by their involvement in subfields such as Molecular Biology, Cell Biology, Cognitive Neuroscience, Cellular and Molecular Neuroscience, and Endocrine and Autonomic Systems.

Notable recent papers authored or co-authored by Okamoto include:

  • "Zebrafish capable of generating future state prediction error show improved active avoidance behavior in virtual reality," 2021, Nature Communications
  • "Habenula as the experience-dependent controlling switchboard of behavior and attention in social conflict and learning," 2021, Current Opinion in Neurobiology
  • "The Dorsal Lateral Habenula-Interpeduncular Nucleus Pathway Is Essential for Left-Right-Dependent Decision Making in Zebrafish," 2020, Cell Reports
  • "Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene," 2020, Cell Reports
  • "Dynamic Thermal Corridor May Connect Endangered Loggerhead Sea Turtles Across the Pacific Ocean," 2021, Frontiers in Marine Science

Okamoto has collaborated frequently with a group of co-authors, including Makio Torigoe, Hisaya Kakinuma, Yuki Tanimoto, Toshiyuki Shiraki, and Hideaki Shimazaki. Their joint efforts demonstrate a consistent focus on neurobiological mechanisms and behavioral studies.

Best Publications

  • Visualization of Cranial Motor Neurons in Live Transgenic Zebrafish Expressing Green Fluorescent Protein Under the Control of the Islet-1 Promoter/Enhancer

    Shin-ichi Higashijima;Yoshiki Hotta;Hitoshi Okamoto

  • High-frequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin

    Shin-ichi Higashijima;Hitoshi Okamoto;Naoto Ueno;Yoshiki Hotta

  • Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos

    Hideki Ando;Toshiaki Furuta;Roger Y. Tsien;Hitoshi Okamoto

  • The habenula is crucial for experience-dependent modification of fear responses in zebrafish

    Masakazu Agetsuma;Hidenori Aizawa;Tazu Aoki;Ryoko Nakayama

  • Molecular characterization of the subnuclei in rat habenula

    Hidenori Aizawa;Megumi Kobayashi;Sayaka Tanaka;Tomoki Fukai

  • N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites.

    Ichiro Masai;Zsolt Lele;Masahiro Yamaguchi;Atsuko Komori

  • From the olfactory bulb to higher brain centers: Genetic visualization of secondary olfactory pathways in zebrafish

    Nobuhiko Miyasaka;Kozo Morimoto;Tatsuya Tsubokawa;Shin-ichi Higashijima

  • Developmental regulation of islet-1 mRNA expression during neuronal differentiation in embryonic zebrafish.

    Akihiro Inoue;Mika Takahashi;Kohei Hatta;Yoshiki Hotta;Yoshiki Hotta

  • Identification of the Zebrafish Ventral Habenula As a Homolog of the Mammalian Lateral Habenula

    Ryunosuke Amo;Hidenori Aizawa;Mikako Takahoko;Megumi Kobayashi

  • Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm.

    Michihiro Mieda;Daisuke Ono;Emi Hasegawa;Hitoshi Okamoto

  • Precise in-frame integration of exogenous DNA mediated by CRISPR/Cas9 system in zebrafish

    Yu Hisano;Tetsushi Sakuma;Shota Nakade;Rie Ohga

  • Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways

    Masahiro Yamaguchi;Noriko Tonou-Fujimori;Atsuko Komori;Ryu Maeda

  • The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger

    Ryunosuke Amo;Ryunosuke Amo;Felipe Fredes;Masae Kinoshita;Ryo Aoki;Ryo Aoki

  • Illuminating cell-cycle progression in the developing zebrafish embryo

    Mayu Sugiyama;Asako Sakaue-Sawano;Tadahiro Iimura;Kiyoko Fukami

  • Laterotopic Representation of Left-Right Information onto the Dorso-Ventral Axis of a Zebrafish Midbrain Target Nucleus

    Hidenori Aizawa;Isaac H. Bianco;Takanori Hamaoka;Toshio Miyashita

  • Midline Signals Regulate Retinal Neurogenesis in Zebrafish

    Ichiro Masai;Derek L Stemple;Hitoshi Okamoto;Stephen W Wilson

  • Social conflict resolution regulated by two dorsal habenular subregions in zebrafish

    Ming-Yi Chou;Ryunosuke Amo;Masae Kinoshita;Bor-Wei Cherng

  • The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation

    Ana Sofia Rocha;Ana Sofia Rocha;Ana Sofia Rocha;Valerie P I Vidal;Valerie P I Vidal;Valerie P I Vidal;Marjolijn Mertz;Marjolijn Mertz;Timothy Kendall

  • R-spondin3 is required for mouse placental development.

    Motoko Aoki;Michihiro Mieda;Toshio Ikeda;Yoshio Hamada

  • Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression.

    Osamu Uemura;Yohei Okada;Yohei Okada;Hideki Ando;Mickael Guedj

Frequent Co-Authors

Yoshiki Hotta
Yoshiki Hotta University of Tokyo
Shin-ichi Higashijima
Shin-ichi Higashijima National Institutes of Natural Sciences
Tomoki Fukai
Tomoki Fukai Okinawa Institute of Science and Technology
Michihiro Mieda
Michihiro Mieda Kanazawa University
Koichi Kawakami
Koichi Kawakami National Institute of Genetics
Stephen W. Wilson
Stephen W. Wilson University College London
Yoshikazu Isomura
Yoshikazu Isomura Tamagawa University
Toshio Ohshima
Toshio Ohshima Waseda University
Kuniyoshi L. Sakai
Kuniyoshi L. Sakai University of Tokyo

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