World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
13657
World Ranking
9243
National Ranking
125

Overview

Håkan Billig is affiliated with the University of Gothenburg in Sweden and has conducted research primarily within the fields of Medicine and Immunology and Microbiology. Their work spans several subfields including Obstetrics and Gynecology, Immunology, Reproductive Medicine, Pediatrics, Perinatology and Child Health, and Epidemiology.

The scientist's research topics emphasize areas related to pregnancy and reproductive health. Key topics in their work include:

  • Pregnancy and preeclampsia studies
  • Reproductive System and Pregnancy
  • Birth, Development, and Health
  • Ovarian function and disorders
  • Gestational Diabetes Research and Management
  • Endometriosis Research and Treatment
  • Liver Disease Diagnosis and Treatment

Billig has published in several scientific venues, particularly those relevant to endocrinology, reproduction, and molecular biology. Frequent publication venues include:

  • Molecular Human Reproduction
  • Journal of Endocrinology
  • The Journal of Clinical Endocrinology & Metabolism
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Journal of Molecular Medicine

Selected recent papers showcase investigations into biochemical and molecular pathways related to polycystic ovary syndrome (PCOS) and reproductive endocrinology:

  • "Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats," 2020, Journal of Endocrinology
  • "TLR4-Associated IRF-7 and NFκB Signaling Act as a Molecular Link Between Androgen and Metformin Activities and Cytokine Synthesis in the PCOS Endometrium," 2020, The Journal of Clinical Endocrinology & Metabolism
  • "Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome," 2021, Molecular Human Reproduction
  • "Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats," 2021, The Journal of Steroid Biochemistry and Molecular Biology
  • "Alterations of endometrial epithelial-mesenchymal transition and MAPK signalling components in women with PCOS are partially modulated by metformin in vitro," 2020, Molecular Human Reproduction

Throughout their career, Billig has frequently collaborated with other researchers. Notable frequent co-authors include:

  • Ruijin Shao
  • Yuehui Zhang
  • Min Hu
  • Mats Brännström
  • Peng Cui

Best Publications

  • Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis.

    H. Billig;I. Furuta;A. J. W. Hsueh

  • Expression of Functional Leptin Receptors in the Human Ovary

    Cecilia Karlsson;Kajsa Lindell;Eva Svensson;Eva Svensson;Christina Bergh

  • Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages

    H. Billig;I. Furuta;C. Rivier;J. Tapanainen

  • Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism.

    J. L. Tilly;H. Billig;K. I. Kowalski;A. J. W. Hsueh

  • Hormonal Regulation of Apoptosis in Early Antral Follicles: Follicle-Stimulating Hormone as a Major Survival Factor*

    S.-Y. Chun;K. M. Eisenhauer;S. Minami;H. Billig

  • Gonadotropin Suppression of Apoptosis in Cultured Preovulatory Follicles: Mediatory Role of Endogenous Insulin-Like Growth Factor I*

    Sang-Young Chun;H. Billig;J. L. Tilly;I. Furuta

  • Survival factors regulating ovarian apoptosis-dependence on follicle differentiation

    Emilia Markström;Eva Ch Svensson;Ruijin Shao;Bodil Svanberg

  • Gonadotropin-releasing hormone directly induces apoptotic cell death in the rat ovary: biochemical and in situ detection of deoxyribonucleic acid fragmentation in granulosa cells

    H. Billig;I. Furuta;A. J. W. Hsueh

  • Experimentally induced cryptorchidism increases apoptosis in rat testis.

    Toshihiko Shikone;Håkan Billig;Aaron J.W. Hsueh

  • Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis-related proteins, and transcription factor GATA-4.

    Tommi E Vaskivuo;M Anttonen;R Herva;H Billig

  • Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue.

    Louise Nilsson;Nadine Binart;Mohammad Bohlooly-Y;Margareta Bramnert

  • Gonadal cell apoptosis.

    A J Hsueh;K Eisenhauer;S Y Chun;S Y Hsu

  • Preantral Ovarian Follicles in Serum-Free Culture: Suppression of Apoptosis after Activation of the Cyclic Guanosine 3′,5′-Monophosphate Pathway and Stimulation of Growth and Differentiation by Follicle-Stimulating Hormone

    Elizabeth McGee;Norah Spears;Sawako Minami;Sheau-Yu Hsu

  • Immunohistochemical localization of insulin-like growth factor I in the adult rat.

    H. A. Hansson;A. Nilsson;J. Isgaard;H. Billig

  • Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1α in adult mouse brain and heart in vivo

    Ruijin Shao;Fu-Ping Zhang;Fei Tian;P Anders Friberg

  • Gonadal cell apoptosis: hormone-regulated cell demise

    Håkan Billig;Sang-Young Chun;Karen Eisenhauer;Aaron J. W. Hsueh

  • Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.

    J. L. Tilly;T. Aihara;K. Nishimori;Xiao-Chi Jia

  • Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue

    Charlotte Ling;Louise Svensson;Birgitta Odén;Birgitta Weijdegård

  • Endometrial progesterone resistance and PCOS.

    Xin Li;Xin Li;Yi Feng;Yi Feng;Jin Fang Lin;Håkan Billig

  • Apoptotic Cell Death in the Normal and Cryptorchid Human Testis: The Effect of Human Chorionic Gonadotropin on Testicular Cell Survival

    Pirjetta Heiskanen;Håkan Billig;Jorma Toppari;Marko Kaleva

Frequent Co-Authors

Aaron J. W. Hsueh
Aaron J. W. Hsueh Stanford University
Elisabet Stener-Victorin
Elisabet Stener-Victorin Karolinska Institute
D. G. Joakim Larsson
D. G. Joakim Larsson University of Gothenburg
Lena M. S. Carlsson
Lena M. S. Carlsson University of Gothenburg
Jonathan L. Tilly
Jonathan L. Tilly Northeastern University
Peter Thomas
Peter Thomas The University of Texas at Austin
Ola Nilsson
Ola Nilsson Karolinska Institute
Xiaoyang Wang
Xiaoyang Wang University of Gothenburg
Changlian Zhu
Changlian Zhu University of Gothenburg
Lin He
Lin He Shanghai Jiao Tong University

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