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Biology and Biochemistry

D-Index
43
Citations
7168
World Ranking
19398
National Ranking
619

Overview

Graziella Orefici is affiliated with the Istituto Superiore di Sanità in Italy and conducts research primarily within the field of Medicine. Their work focuses on several interconnected subfields including Public Health, Environmental and Occupational Health, Epidemiology, Molecular Biology, and Immunology.

The researcher has authored multiple scientific papers that address topics related to infectious diseases, particularly streptococcal infections, neonatal and maternal infections, and immune system responses. Frequent themes in their publications include Streptococcal Infections and Treatments, Neonatal and Maternal Infections, Pneumonia and Respiratory Infections, Inflammasome and Immune Disorders, and Immune Response and Inflammation.

Recent publications feature studies on the epidemiology and clinical impact of Group B Streptococcus (Streptococcus agalactiae) in Europe. Notable papers include:

  • Neonatal invasive disease caused by Streptococcus agalactiae in Europe: the DEVANI multi-center study, 2022, Infection
  • Maternal Streptococcus agalactiae colonization in Europe: data from the multi-center DEVANI study, 2024, Infection
  • Publisher Correction: Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon, 2020, Scientific Reports

Graziella Orefici frequently collaborates with other researchers in related disciplines. Regular coauthors include Roberta Creti, Immaculada Margarit, Florens Lohrmann, Markus Hufnagel, and Mirjam Kunze. These collaborations contribute to the multidisciplinary nature of the research and publication output.

The scientist's work is published mainly in the journals Infection and Scientific Reports, reflecting a focus on infectious diseases and immune-related research areas.

In summary, Graziella Orefici's research spans several important aspects of infectious disease epidemiology and immune response, with particular attention to the clinical and public health implications of streptococcal infections among neonatal and maternal populations.

Best Publications

  • Infection of Human Macrophages and Dendritic Cells with Mycobacterium tuberculosis Induces a Differential Cytokine Gene Expression That Modulates T Cell Response

    Elena Giacomini;Elisabetta Iona;Lucietta Ferroni;Minja Miettinen

  • Survey for virulence determinants among Enterococcus faecalis isolated from different sources.

    Roberta Creti;Monica Imperi;Lucia Bertuccini;Francesca Fabretti

  • A multiplex PCR assay for the direct identification of the capsular type (Ia to IX) of Streptococcus agalactiae.

    Monica Imperi;Marco Pataracchia;Giovanna Alfarone;Lucilla Baldassarri

  • Enterococcus spp. produces slime and survives in rat peritoneal macrophages

    Lucilla Baldassarri;Roberto Cecchini;Lucia Bertuccini;Maria G. Ammendolia

  • Therapeutic Failures of Antibiotics Used To Treat Macrolide-Susceptible Streptococcus pyogenes Infections May Be Due to Biofilm Formation

    Lucilla Baldassarri;Roberta Creti;Simona Recchia;Monica Imperi

  • Molecular Epidemiology and Distribution of Serotypes, Surface Proteins, and Antibiotic Resistance among Group B Streptococci in Italy

    Giovanni Gherardi;Monica Imperi;Lucilla Baldassarri;Marco Pataracchia

  • Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis.

    Maria Elena Remoli;Elena Giacomini;Georges Lutfalla;Elisabetta Dondi

  • Multiplex PCR Assay for Direct Identification of Group B Streptococcal Alpha-Protein-Like Protein Genes

    Roberta Creti;Francesca Fabretti;Graziella Orefici;Christina von Hunolstein

  • rpoB mutations in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Italy.

    G. Pozzi;M. Meloni;E. Iona;G. Orrù

  • Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitum beta-lactamase genes cloned from a natural isolate and a high-level beta-lactamase producer.

    J Timm;M G Perilli;Colette Duez;J Trias

  • Group A streptococcal infections and tic disorders in an Italian pediatric population.

    Francesco Cardona;Graziella Orefici

  • Group B streptococci persist inside macrophages

    Paola Cornacchione;Lucia Scaringi;Katia Fettucciari;Emanuela Rosati

  • Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefield T serotypes.

    Fabiana Falugi;Chiara Zingaretti;Vittoria Pinto;Massimo Mariani

  • A novel resistance mechanism to triclosan that suggests horizontal gene transfer and demonstrates a potential selective pressure for reduced biocide susceptibility in clinical strains of Staphylococcus aureus.

    Maria Laura Ciusa;Leonardo Furi;Daniel Knight;Francesca Decorosi

  • Evaluation of Reduced Susceptibility to Quaternary Ammonium Compounds and Bisbiguanides in Clinical Isolates and Laboratory-Generated Mutants of Staphylococcus aureus

    Leonardo Furi;Maria Laura Ciusa;Daniel Knight;Valeria Di Lorenzo;Valeria Di Lorenzo

  • Mycobacterium tuberculosis subverts the differentiation of human monocytes into dendritic cells

    Sabrina Mariotti;Raffaela Teloni;Elisabetta Iona;Lanfranco Fattorini

  • The Extra Cytoplasmic Function Sigma Factor σE Is Essential for Mycobacterium tuberculosis Virulence in Mice

    Riccardo Manganelli;Lanfranco Fattorini;Dejiang Tan;Elisabetta Iona

  • Prevention of group B streptococcal neonatal disease revisited. the DEVANI European project

    J. Rodriguez-Granger;J. C. Alvargonzalez;A. Berardi;R. Berner

  • emm Types, Virulence Factors, and Antibiotic Resistance of Invasive Streptococcus pyogenes Isolates from Italy: What Has Changed in 11 Years?

    Roberta Creti;Monica Imperi;Lucilla Baldassarri;Marco Pataracchia

  • In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis.

    Lanfranco Fattorini;Renato Gennaro;Margherita Zanetti;Dejiang Tan

Frequent Co-Authors

Lucilla Baldassarri
Lucilla Baldassarri Istituto Superiore di Sanità
Marco R. Oggioni
Marco R. Oggioni University of Leicester
Francesco Bistoni
Francesco Bistoni University of Perugia
Giuseppe Arancia
Giuseppe Arancia Istituto Superiore di Sanità
Gianni Pozzi
Gianni Pozzi University of Siena
Antonio Cassone
Antonio Cassone University of Siena
Gianfranco Donelli
Gianfranco Donelli Istituto Superiore di Sanità
Lucio Montanaro
Lucio Montanaro University of Bologna
Carla Renata Arciola
Carla Renata Arciola University of Bologna
Androulla Efstratiou
Androulla Efstratiou Public Health England

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