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Christine Perret

Christine Perret

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
13619
World Ranking
12453
National Ranking
459

Overview

Christine Perret is affiliated with Université Paris Cité in France and has contributed extensively to research in biochemistry, genetics, and molecular biology, with a notable focus also on medicine. Their work spans several specialized subfields including molecular biology, surgery, genetics, cell biology, and radiology, nuclear medicine, and imaging.

Their research topics cover a range of areas chiefly involving mechanisms related to cancer and metabolism. These include:

  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related gene regulation
  • Digestive system and related health
  • Metabolism, diabetes, and cancer
  • Pancreatic function and diabetes
  • Ubiquitin and proteasome pathways
  • Radiopharmaceutical chemistry and applications

Christine Perret has published in multiple research venues, with recurrent contributions to:

  • Nature Communications
  • médecine/sciences
  • Nature
  • Proceedings of the National Academy of Sciences
  • Journal of Hepatology

Recent publications highlight a focus on cellular and molecular mechanisms involved in cancer initiation, autophagy, metabolism, and tumor growth. Selected recent papers include:

  • NOTUM from Apc-mutant cells biases clonal competition to initiate cancer, 2021, Nature
  • Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity, 2020, Proceedings of the National Academy of Sciences
  • Lkb1 suppresses amino acid-driven gluconeogenesis in the liver, 2020, Nature Communications
  • Deleting the β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumor growth, 2022, Journal of Hepatology
  • Notum deacylates octanoylated ghrelin, 2021, Molecular Metabolism

Among frequent coauthors associated with Christine Perret's work are Béatrice Romagnolo, Pascale Bossard, Alain Schmitt, Pierre-Alexandre Just, and Mathilde Savall, reflecting collaborations that span various aspects of molecular biology and cancer research.

Best Publications

  • SOMATIC MUTATIONS OF THE BETA -CATENIN GENE ARE FREQUENT IN MOUSE AND HUMAN HEPATOCELLULAR CARCINOMAS

    Alix de La Coste;Béatrice Romagnolo;Pierre Billuart;Claire-Angélique Renard

  • Mutations of β-Catenin in Adrenocortical Tumors: Activation of the Wnt Signaling Pathway Is a Frequent Event in both Benign and Malignant Adrenocortical Tumors

    Frédérique Tissier;Catherine Cavard;Lionel Groussin;Karine Perlemoine

  • Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver

    Samira Benhamouche;Thomas Decaens;Cécile Godard;Régine Chambrey

  • New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism.

    Axelle Cadoret;Christine Ovejero;Benoit Terris;Evelyne Souil

  • Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation

    Christèle Desbois-Mouthon;Axelle Cadoret;Marie-José Blivet-Van Eggelpoël

  • Liver-targeted disruption of Apc in mice activates β-catenin signaling and leads to hepatocellular carcinomas

    S. Colnot;T. Decaens;M. Niwa-Kawakita;C. Godard

  • Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the β-catenin gene

    Sihem Saadi-Kheddouci;Dominique Berrebi;Béatrice Romagnolo;Françoise Cluzeaud

  • Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine.

    Pauline Andreu;Sabine Colnot;Cécile Godard;Sophie Gad

  • Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)

    Aurélie Durand;Bridgitte Donahue;Grégory Peignon;Franck Letourneur

  • Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas.

    J Zucman-Rossi;S Benhamouche;C Godard;S Boyault

  • EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma

    Benoit Terris;Benoit Terris;Catherine Cavard;Catherine Cavard;Christine Perret;Christine Perret

  • Hepatomegaly in Transgenic Mice Expressing an Oncogenic Form of β-Catenin

    Axelle Cadoret;Christine Ovejero;Sihem Saadi-Kheddouci;Evelyne Souil

  • Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity

    Patricia Legoix;Olivier Bluteau;Jan Bayer;Jan Bayer;Christine Perret

  • Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth

    Jonathan Lévy;Wulfran Cacheux;Medhi Ait Bara;Antoine L’Hermitte

  • Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers.

    Sabine Colnot;Michiko Niwa-Kawakita;Ghislaine Hamard;Cécile Godard

  • Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.

    Claire-Angélique Renard;Charlotte Labalette;Carolina Armengol;Delphine Cougot

  • Identification of the IFITM Family as a New Molecular Marker in Human Colorectal Tumors

    Pauline Andreu;Sabine Colnot;Cécile Godard;Pierre Laurent-Puig

  • Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice

    Marie Anson;Anne-Marie Crain-Denoyelle;Véronique Baud;Fanny Chereau

  • Cholestasis is a marker for hepatocellular carcinomas displaying β-catenin mutations

    V. Audard;G. Grimber;C. Elie;B. Radenen

  • Stabilization of β-catenin affects mouse embryonic liver growth and hepatoblast fate

    Thomas Decaens;Thomas Decaens;Cécile Godard;Cécile Godard;Aurélien de Reyniès;David S. Rickman

Frequent Co-Authors

Claude Desplan
Claude Desplan New York University
Alain Schmitt
Alain Schmitt Institut Cochin
Marc Foretz
Marc Foretz Université Paris Cité
Pierre Laurent-Puig
Pierre Laurent-Puig Université Paris Cité
Jessica Zucman-Rossi
Jessica Zucman-Rossi Université Paris Cité
Benoit Viollet
Benoit Viollet Institut Cochin
Michel Huerre
Michel Huerre Institut Pasteur

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