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Andrew J. Leigh Brown

Andrew J. Leigh Brown

D-Index & Metrics

Microbiology

D-Index
63
Citations
12845
World Ranking
2766
National Ranking
245

Research.com Recognitions

  • 2006 - Fellow of the Royal Society of Edinburgh

Overview

Andrew J. Leigh Brown is affiliated with the University of Edinburgh in the United Kingdom. Their research spans the fields of biochemistry, genetics, molecular biology, and medicine, with significant contributions particularly to surgery and molecular biology subfields. The scientist's work has a focus on cholesterol and lipid metabolism, cancer, lipids and metabolism, lipid metabolism and biosynthesis, plant biochemistry and biosynthesis, ubiquitin and proteasome pathways, steroid chemistry and biochemistry, and peroxisome proliferator-activated receptors.

They have published extensively across various scientific journals, including frequent publications in:

  • arXiv (Cornell University)
  • Journal of Biological Chemistry
  • The FASEB Journal
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • Journal of Lipid Research

Several recent papers associated with Andrew J. Leigh Brown include:

  • Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis, 2020, Gastroenterology
  • Squalene monooxygenase: a journey to the heart of cholesterol synthesis, 2020, Progress in Lipid Research
  • A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols, 2021, Science
  • Oxysterols: From physiological tuners to pharmacological opportunities, 2020, British Journal of Pharmacology
  • A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate, 2020, Proceedings of the National Academy of Sciences

Frequent coauthors include:

  • Laura J. Sharpe
  • Hudson W. Coates
  • Isabelle M. Capell-Hattam
  • Hongyuan Yang
  • Nicole Fenton

In recognition of their academic contributions, Andrew J. Leigh Brown was awarded the title of Fellow of the Royal Society of Edinburgh in 2006.

Best Publications

  • Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection.

    L. Q. Zhang;P. Mackenzie;A. Cleland;E. C. Holmes

  • Episodic Sexual Transmission of HIV Revealed by Molecular Phylodynamics

    Fraser Lewis;Gareth J Hughes;Andrew Rambaut;Anton Pozniak

  • Human Macrophages Accumulate HIV‐1 Particles in MHC II Compartments

    Graça Raposo;Marilyn Moore;Donald Innes;Richtje Leijendekker

  • Molecular evidence for genetic mixing of Arctic and Antarctic subpolar populations of planktonic foraminifers

    Kate F. Darling;Christopher M. Wade;Christopher M. Wade;Iain A. Stewart;Dick Kroon

  • Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1.

    Peter Simmonds;P Balfe;Ca Ludlam;Jo Bishop

  • Automated analysis of phylogenetic clusters

    Manon Ragonnet-Cronin;Emma B. Hodcroft;Stéphane Hué;Esther Fearnhill

  • Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient

    Edward C. Holmes;Lin Qi Zhang;Peter Simmonds;Christopher A. Ludlam

  • Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence

    M. C. Strain;H. F. Günthard;D. V. Havlir;C. C. Ignacio

  • Concurrent evolution of human immunodeficiency virus type 1 in patients infected from the same source: rate of sequence change and low frequency of inactivating mutations.

    P Balfe;Peter Simmonds;Ca Ludlam;Jo Bishop

  • Analysis of HIV-1 env gene sequences reveals evidence for a low effective number in the viral population

    Andrew J. Leigh Brown

  • Phylodynamics of Infectious Disease Epidemics

    Erik M. Volz;Sergei L. Kosakovsky Pond;Melissa J. Ward;Andrew J. Leigh Brown

  • Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo: implications for models of HIV pathogenesis.

    P. Simmonds;Lin Qi Zhang;F. Mcomish;P. Balfe

  • Adaptation to different human populations by HIV-1 revealed by codon-based analyses.

    Sergei L Kosakovsky Pond;Simon D. W Frost;Zehava Grossman;Michael B Gravenor

  • HIV-TRACE (TRAnsmission Cluster Engine): a Tool for Large Scale Molecular Epidemiology of HIV-1 and Other Rapidly Evolving Pathogens.

    Sergei L Kosakovsky Pond;Steven Weaver;Andrew J Leigh Brown;Joel O Wertheim

  • Evolution of Envelope Sequences of Human Immunodeficiency Virus Type 1 in Cellular Reservoirs in the Setting of Potent Antiviral Therapy

    Huldrych F. Günthard;Simon D. W. Frost;Andrew J. Leigh-Brown;Caroline C. Ignacio

  • The global transmission network of HIV-1.

    Joel O. Wertheim;Andrew J. Leigh Brown;N. Lance Hepler;Sanjay R. Mehta

  • Transmission Network Parameters Estimated From HIV Sequences for a Nationwide Epidemic

    Andrew J. Leigh Brown;Samantha J. Lycett;Lucy Weinert;Gareth J. Hughes

  • Multiple sites in HIV-1 reverse transcriptase associated with virological response to combination therapy.

    Heather M. Precious;Huldrych F. Günthard;Joseph K. Wong;Richard T. D'Aquila

  • Transmission Fitness of Drug-Resistant Human Immunodeficiency Virus and the Prevalence of Resistance in the Antiretroviral-Treated Population

    Andrew J Leigh Brown;Simon D. W Frost;W. Christopher Mathews;Keith Dawson

  • Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: the relative roles of drift and selection.

    Simon D. W. Frost;Monique Nijhuis;Rob Schuurman;Charles A. B. Boucher

  • An Evolutionary Model-Based Algorithm for Accurate Phylogenetic Breakpoint Mapping and Subtype Prediction in HIV-1

    Sergei L. Kosakovsky Pond;David Posada;Eric Stawiski;Colombe Chappey

Frequent Co-Authors

Douglas D. Richman
Douglas D. Richman University of California, San Diego
Simon D. W. Frost
Simon D. W. Frost Microsoft (United States)
Paul Kellam
Paul Kellam Imperial College London
Peter Simmonds
Peter Simmonds University of Oxford
Deenan Pillay
Deenan Pillay University College London
David Dunn
David Dunn University College London
Pontiano Kaleebu
Pontiano Kaleebu London School of Hygiene & Tropical Medicine
Christophe Fraser
Christophe Fraser University of Oxford
Sergei L. Kosakovsky Pond
Sergei L. Kosakovsky Pond Temple University
Peter Balfe
Peter Balfe University of Oxford

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