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Genetics

D-Index
61
Citations
31741
World Ranking
3014
National Ranking
1313

Overview

Alexey S. Kondrashov is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans various fields within biochemistry, genetics, and molecular biology with a particular focus on genetics, molecular biology, ecology, evolution, behavior and systematics, pathology and forensic medicine, and cancer research.

The scientist's main areas of study include:

  • Evolution and Genetic Dynamics
  • Genetic diversity and population structure
  • Plant and animal studies
  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Genetic Mapping and Diversity in Plants and Animals

Kondrashov has published in multiple scientific venues, notably including bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, European Journal of Human Genetics, Molecular Biology and Evolution, and eLife. The breakdown of publications by venue highlights a diversity of outlets for their work.

Their recent papers include:

  • Genomic signatures of recombination in a natural population of the bdelloid rotifer Adineta vaga, 2020, Nature Communications
  • Rapid Accumulation of Mutations in Growing Mycelia of a Hypervariable Fungus Schizophyllum commune, 2020, Molecular Biology and Evolution
  • Complex fitness landscape shapes variation in a hyperpolymorphic species, 2022, eLife
  • Discovery of recessive effect of human polymerase δ proofreading deficiency through mutational analysis of POLD1-mutated normal and cancer cells, 2024, European Journal of Human Genetics
  • Extended family with an inherited pathogenic variant in polymerase delta provides strong evidence for recessive effect of proofreading deficiency in human cells, 2022, bioRxiv (Cold Spring Harbor Laboratory)

Kondrashov collaborates frequently with several coauthors, including Georgii A. Bazykin, Tatiana V. Neretina, Elena Zvyagina, Anna Fedotova, and Sergey Naumenko. These partnerships have resulted in multiple joint publications across their fields of study.

Best Publications

  • A method and server for predicting damaging missense mutations.

    Ivan A Adzhubei;Steffen Schmidt;Leonid Peshkin;Vasily E Ramensky

  • Deleterious mutations and the evolution of sexual reproduction

    Alexey S. Kondrashov

  • Prediction of deleterious human alleles

    Shamil Sunyaev;Vasily Ramensky;Ina Koch;Warren Lathe

  • Classification of Hypotheses on the Advantage of Amphimixis

    A. S. Kondrashov

  • Interactions among quantitative traits in the course of sympatric speciation

    Alexey S. Kondrashov;Fyodor A. Kondrashov

  • Local fitness landscape of the green fluorescent protein.

    Karen S. Sarkisyan;Dmitry A. Bolotin;Margarita V. Meer;Dinara R. Usmanova;Dinara R. Usmanova

  • Direct estimates of human per nucleotide mutation rates at 20 loci causing mendelian diseases

    Alexey S. Kondrashov

  • Selection against harmful mutations in large sexual and asexual populations.

    Alexey S. Kondrashov

  • Genomic evidence for ameiotic evolution in the bdelloid rotifer Adineta vaga

    Jean François Flot;Boris Hespeels;Xiang Li;Benjamin Noel

  • Genome Alignment, Evolution of Prokaryotic Genome Organization, and Prediction of Gene Function Using Genomic Context

    Yuri I. Wolf;Igor B. Rogozin;Alexey S. Kondrashov;Eugene V. Koonin

  • Dobzhansky–Muller incompatibilities in protein evolution

    Alexey S. Kondrashov;Shamil Sunyaev;Fyodor A. Kondrashov

  • The Impact of Comparative Genomics on Our Understanding of Evolution

    Eugene V Koonin;L Aravind;Alexey S Kondrashov

  • Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over?

    Alexey S. Kondrashov

  • A universal trend of amino acid gain and loss in protein evolution

    I. King Jordan;Fyodor A. Kondrashov;Ivan A. Adzhubei;Yuri I. Wolf

  • Coevolution of costly mate choice and condition-dependent display of good genes

    David Houle;Alexey S. Kondrashov

  • Role of selection in fixation of gene duplications.

    Fyodor A. Kondrashov;Alexey S. Kondrashov

  • Rapid decline of fitness in panmictic populations of Drosophila melanogaster maintained under relaxed natural selection

    Svetlana A. Shabalina;Lev Yu. Yampolsky;Alexey S. Kondrashov

  • Haploidy or diploidy: which is better?

    Alexey S. Kondrashov;James F. Crow

  • Sympatric speciation: when is it possible?

    Alexey S. Kondrashov;Mikhail V. Mina

  • On the origin of species by means of assortative mating

    Alexey S. Kondrashov;Max Shpak

Frequent Co-Authors

Fyodor A. Kondrashov
Fyodor A. Kondrashov Institute of Science and Technology Austria
Svetlana A. Shabalina
Svetlana A. Shabalina National Center for Biotechnology Information
Shamil R. Sunyaev
Shamil R. Sunyaev Harvard University
Eugene V. Koonin
Eugene V. Koonin National Institutes of Health
Yuri I. Wolf
Yuri I. Wolf National Institutes of Health
Inna Dubchak
Inna Dubchak Lawrence Berkeley National Laboratory
David Houle
David Houle Florida State University
Eric Wajnberg
Eric Wajnberg INRAE : Institut national de recherche pour l'agriculture, l'alimentation et l'environnement
Etienne G. J. Danchin
Etienne G. J. Danchin INRAE : Institut national de recherche pour l'agriculture, l'alimentation et l'environnement
Francis S. Collins
Francis S. Collins National Institutes of Health

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