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Biology and Biochemistry

D-Index
62
Citations
10308
World Ranking
11051
National Ranking
4775

Overview

Ajay P. Singh is affiliated with the University of South Alabama in the United States. Their research portfolio spans multiple disciplines within biomedicine, primarily focusing on biochemistry, genetics, and molecular biology as well as medicine. Singh has produced substantial work involving molecular biology and cancer research, with additional contributions in pulmonary and respiratory medicine and biomedical engineering.

Their research explores specialized subfields including molecular biology, cancer research, pulmonary and respiratory medicine, oncology, and biomedical engineering. Key topics of study developed by Singh comprise microRNA in disease regulation, prostate cancer treatment and research, cancer associated with hypoxia and metabolism, RNA modifications linked to cancer, mitochondrial function and pathology, cancer lipid metabolism, and extracellular vesicles in disease contexts.

Singh's frequent publication venues reflect a continued focus on cancer and molecular sciences. These venues are:

  • Cancer Research
  • Cancers
  • International Journal of Molecular Sciences
  • Cureus
  • Cancer Letters

Collaborative work is an important aspect of Singh's academic activity. Frequent coauthors include:

  • Seema Singh
  • Mohammad Aslam Khan
  • Kunwar Somesh Vikramdeo
  • Santanu Dasgupta
  • Shashi Anand

Recent notable publications by Ajay P. Singh include:

  • Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis, 2021, The FASEB Journal
  • Resistin: An inflammatory cytokine with multi-faceted roles in cancer, 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • Dysregulation of metabolic enzymes in tumor and stromal cells: Role in oncogenesis and therapeutic opportunities, 2020, Cancer Letters
  • Platinum-resistant ovarian cancer: From drug resistance mechanisms to liquid biopsy-based biomarkers for disease management, 2021, Seminars in Cancer Biology
  • Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research, 2020, Cancers

Their research investigates cellular and molecular mechanisms relevant to cancer and metabolic regulation, illustrating an interdisciplinary approach that bridges basic molecular biology and clinical oncology applications. Areas such as mitochondrial dynamics, inflammatory cytokines, metabolic enzyme dysfunction within tumor microenvironments, and drug resistance in ovarian cancer are central to their work.

Best Publications

  • Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications.

    Girijesh Kumar Patel;Mohammad Aslam Khan;Haseeb Zubair;Sanjeev Kumar Srivastava

  • Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis.

    Mary Adebayo;Seema Singh;Ajay Pratap Singh;Santanu Dasgupta

  • Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis.

    Ajay P. Singh;Nicolas Moniaux;Subhash C. Chauhan;Jane L. Meza

  • Structure, evolution, and biology of the MUC4 mucin

    Pallavi Chaturvedi;Ajay P. Singh;Surinder Kumar Batra

  • CXCL12–CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy

    S Singh;S K Srivastava;A Bhardwaj;L B Owen

  • Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK.

    Girijesh Kumar Patel;Mohammad Aslam Khan;Arun Bhardwaj;Sanjeev K Srivastava

  • Honokiol: a novel natural agent for cancer prevention and therapy

    Sumit Arora;Seema Singh;Gary A. Piazza;Carlo M. Contreras

  • MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins

    Pallavi Chaturvedi;Ajay P. Singh;Nicolas Moniaux;Shantibhushan Senapati

  • MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells

    Sanjeev K. Srivastava;Arun Bhardwaj;Seema Singh;Sumit Arora

  • An Undesired Effect of Chemotherapy: GEMCITABINE PROMOTES PANCREATIC CANCER CELL INVASIVENESS THROUGH REACTIVE OXYGEN SPECIES-DEPENDENT, NUCLEAR FACTOR κB- AND HYPOXIA-INDUCIBLE FACTOR 1α-MEDIATED UP-REGULATION OF CXCR4*

    Sumit Arora;Arun Bhardwaj;Seema Singh;Sanjeev K. Srivastava

  • Emerging Roles of MUC4 in Cancer: A Novel Target for Diagnosis and Therapy

    Ajay P. Singh;Pallavi Chaturvedi;Surinder K. Batra

  • MUC4 Mucin Interacts with and Stabilizes the HER2 Oncoprotein in Human Pancreatic Cancer Cells

    Pallavi Chaturvedi;Ajay P. Singh;Subhankar Chakraborty;Subhash C. Chauhan

  • Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125)

    Subhash C Chauhan;Ajay P Singh;Fernanda Ruiz;Sonny L Johansson

  • CXCL12/CXCR4 Protein Signaling Axis Induces Sonic Hedgehog Expression in Pancreatic Cancer Cells via Extracellular Regulated Kinase- and Akt Kinase-mediated Activation of Nuclear Factor κB IMPLICATIONS FOR BIDIRECTIONAL TUMOR-STROMAL INTERACTIONS

    Ajay P. Singh;Sumit Arora;Arun Bhardwaj;Sanjeev K. Srivastava

  • Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells.

    Sumit Arora;Arun Bhardwaj;Sanjeev K. Srivastava;Seema Singh

  • p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway

    Nikhil Tyagi;Arun Bhardwaj;Ajay P. Singh;Steven McClellan

  • CXCL8 and its cognate receptors in melanoma progression and metastasis.

    Seema Singh;Ajay P Singh;Bhawna Sharma;Laurie B Owen

  • Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer

    Ajay P Singh;Shantibhusan Senapati;Moorthy P Ponnusamy;Maneesh Jain

  • Penetratin Improves Tumor Retention of Single-Chain Antibodies: A Novel Step toward Optimization of Radioimmunotherapy of Solid Tumors

    Maneesh Jain;Subhash C. Chauhan;Ajay P. Singh;Ganesh Venkatraman

  • Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas.

    Ajay P. Singh;Subhash C. Chauhan;Sangeeta Bafna;Sonny L. Johansson

Frequent Co-Authors

Surinder K. Batra
Surinder K. Batra University of Nebraska Medical Center
William E. Grizzle
William E. Grizzle University of Alabama at Birmingham
Nicholi Vorsa
Nicholi Vorsa Rutgers, The State University of New Jersey
Subhash C. Chauhan
Subhash C. Chauhan The University of Texas Rio Grande Valley
Eddie Reed
Eddie Reed National Institutes of Health
Michael A. Hollingsworth
Michael A. Hollingsworth University of Nebraska Medical Center
Øystein Fodstad
Øystein Fodstad Oslo University Hospital
Rakesh Singh
Rakesh Singh Indian Council of Agricultural Research
Hyun Koo
Hyun Koo University of Pennsylvania

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