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Neuroscience

D-Index
52
Citations
8347
World Ranking
5383
National Ranking
79

Overview

Xuechu Zhen is affiliated with Soochow University in China and is involved in research that intersects biochemistry, neuroscience, and medicine. Their scholarly work primarily spans molecular biology, cellular and molecular neuroscience, neurology, immunology, and cancer research.

The scientist's research topics include:

  • Neuroinflammation and neurodegeneration mechanisms
  • Pharmacological receptor mechanisms and effects
  • Receptor mechanisms and signaling
  • Neuropeptides and animal physiology
  • Tryptophan and brain disorders
  • Nuclear receptors and signaling
  • Immune cells in cancer

Frequent publication venues where Xuechu Zhen has contributed include:

  • Acta Pharmacologica Sinica
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Neuropharmacology
  • Frontiers in Pharmacology

Frequent co-authors collaborating with Xuechu Zhen involve:

  • Huicui Yang
  • Long Tai Zheng
  • John L. Waddington
  • Na Ye
  • Jiaojiao Chen

Recent papers by Xuechu Zhen cover diverse topics related to neuroinflammation, receptor signaling, and protective cellular mechanisms. Selected works include:

  • Early glycolytic reprogramming controls microglial inflammatory activation, 2021, Journal of Neuroinflammation
  • Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases, 2020, Journal of Medicinal Chemistry
  • PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6, 2020, Brain Behavior and Immunity
  • Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke, 2023, Theranostics
  • Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway, 2020, Oxidative Medicine and Cellular Longevity

Best Publications

  • Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders

    Na Ye;John L. Neumeyer;Ross J. Baldessarini;Xuechu Zhen

  • Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke.

    Qin Jin;Jian Cheng;Yang Liu;Jian Wu

  • Early glycolytic reprogramming controls microglial inflammatory activation.

    Junjie Cheng;Rong Zhang;Zhirou Xu;Youliang Ke

  • SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain.

    Li-Qing Jin;Satindra Goswami;Guoping Cai;Xuechu Zhen

  • MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation.

    Jingshu Ni;Xiaoyu Wang;Shuangshuang Chen;Huihui Liu

  • Recent development in studies of tetrahydroprotoberberines: Mechanism in antinociception and drug addiction

    Hongyuan Chu;Guozhang Jin;Eitan Friedman;Xuechu Zhen

  • Dopamine D1 receptor ligands: where are we now and where are we going.

    Jing Zhang;Bing Xiong;Xuechu Zhen;Ao Zhang

  • Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia.

    Ya-Qin Feng;Zhi-Yong Zhou;Xin He;Hao Wang

  • CaMKKβ-dependent Activation of AMP-activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation

    Xiaomei Zhou;Yongjun Cao;Guizhen Ao;Lifang Hu

  • Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone

    Xuechu Zhen;Lei Wei;Qiuqian Wu;Yue Zhang

  • Estrogen regulates responses of dopamine neurons in the ventral tegmental area to cocaine

    Die Zhang;Shen Yang;Chunhao Yang;Guozhang Jin

  • miRNA-3473b contributes to neuroinflammation following cerebral ischemia.

    Xiaoyu Wang;Shuangshuang Chen;Jingshu Ni;Jian Cheng

  • Assessing an ensemble docking-based virtual screening strategy for kinase targets by considering protein flexibility.

    Sheng Tian;Huiyong Sun;Peichen Pan;Dan Li

  • Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease.

    F. Wu;H.-D. Xu;J.-J. Guan;Y.-S. Hou

  • Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

    Zhao-xiang Ren;Ya-fei Zhao;Ting Cao;Xue-chu Zhen

  • Activation of extracellular signal-regulated protein kinases is associated with a sensitized locomotor response to D(2) dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats.

    Guoping Cai;Xuechu Zhen;Kunihiro Uryu;Eitan Friedman

  • Current developments of macrophage migration inhibitory factor (MIF) inhibitors

    Lei Xu;Youyong Li;Huiyong Sun;Xuechu Zhen

  • Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

    Lunlin Mao;Jia Jia;Xiaomei Zhou;Yunqi Xiao

  • Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia

    Q Xia;Q Hu;H Wang;H Yang

  • Discovery of Novel Inhibitors Targeting the Macrophage Migration Inhibitory Factor via Structure-Based Virtual Screening and Bioassays

    Lei Xu;Yu Zhang;Longtai Zheng;Chunhua Qiao

  • Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile

    Haifeng Sun;Liyuan Zhu;Huicui Yang;Wangke Qian

  • Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons

    Kechun Yang;Jun Hu;Linda Lucero;Qiang Liu

  • Modulation of Ca2+ signals by phosphatidylinositol-linked novel D1 dopamine receptor in hippocampal neurons.

    Yuling Ming;Hai Zhang;Lihong Long;Fang Wang

Frequent Co-Authors

John L. Waddington
John L. Waddington Royal College of Surgeons in Ireland
Hong Liu
Hong Liu Shandong University
Youyong Li
Youyong Li Soochow University
Feng Liu
Feng Liu Shanghai Jiao Tong University
Wei Li
Wei Li Harvard University

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