His scientific interests lie mostly in Immunology, Cell biology, Cancer research, Haematopoiesis and Stem cell. His studies in Immunology integrate themes in fields like Hematopoietic stem cell transplantation and Internal medicine. He interconnects Cellular differentiation and Natural killer T cell, T cell, CD8, Antigen-presenting cell in the investigation of issues within Cell biology.
His research integrates issues of Somatic cell, Mutation, Tyrosine kinase, Tumor suppressor gene and Cell cycle in his study of Cancer research. His Haematopoiesis study combines topics from a wide range of disciplines, such as Interleukin 3, Myeloid, Receptor, Signal transduction and SF3B1 Gene. Shigeru Chiba combines subjects such as Endothelial stem cell, Adult stem cell and Notch signaling pathway with his study of Stem cell.
His primary areas of study are Internal medicine, Immunology, Cancer research, Transplantation and Hematopoietic stem cell transplantation. His Internal medicine research includes themes of Gastroenterology, Endocrinology, Surgery and Oncology. His work carried out in the field of Immunology brings together such families of science as Haematopoiesis and Stem cell.
His work in Haematopoiesis addresses issues such as Myeloid, which are connected to fields such as Myeloid leukemia. His Stem cell research is multidisciplinary, relying on both Endothelial stem cell and Bone marrow. His Cancer research study deals with RHOA intersecting with Molecular biology.
Shigeru Chiba mainly focuses on Internal medicine, Cancer research, Bone marrow, Lymphoma and Gastroenterology. The study incorporates disciplines such as Surgery and Oncology in addition to Internal medicine. His studies deal with areas such as Mutation, Gene mutation, T cell, T-cell receptor and RHOA as well as Cancer research.
The Bone marrow study combines topics in areas such as Haematopoiesis, Stromal cell, Transplantation and Nestin. The various areas that he examines in his Haematopoiesis study include Progenitor cell and Myeloid, Immunology. His biological study deals with issues like Hematopoietic stem cell transplantation, which deal with fields such as Melphalan and Graft-versus-host disease.
His primary areas of investigation include Cancer research, Internal medicine, Angioimmunoblastic T-cell lymphoma, Mutation and Lymphoma. His Cancer research research is multidisciplinary, incorporating elements of T cell, Immune system, Primary central nervous system lymphoma and Bone marrow. He has included themes like Haematopoiesis, Precursor cell and Surgery, Transplantation in his Bone marrow study.
His Haematopoiesis study contributes to a more complete understanding of Genetics. Shigeru Chiba combines subjects such as Gastroenterology and Oncology with his study of Internal medicine. Shigeru Chiba works mostly in the field of Angioimmunoblastic T-cell lymphoma, limiting it down to topics relating to RHOA and, in certain cases, Molecular biology, Receptor, Gene mutation and T-cell receptor, as a part of the same area of interest.
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Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida;Masashi Sanada;Yuichi Shiraishi;Daniel Nowak.
Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin
Toshio Kitamura;Tsuyoshi Tange;Takashi Terasawa;Shigeru Chiba.
Journal of Cellular Physiology (1989)
A Robust Algorithm for Copy Number Detection Using High-Density Oligonucleotide Single Nucleotide Polymorphism Genotyping Arrays
Yasuhito Nannya;Masashi Sanada;Kumi Nakazaki;Noriko Hosoya.
Cancer Research (2005)
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.
Motoshi Ichikawa;Takashi Asai;Toshiki Saito;Go Yamamoto.
Nature Medicine (2004)
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.
Toshiki Saito;Shigeru Chiba;Motoshi Ichikawa;Atsushi Kunisato.
Frequent inactivation of A20 in B-cell lymphomas
Motohiro Kato;Masashi Sanada;Itaru Kato;Yasuharu Sato.
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
Mamiko Sakata-Yanagimoto;Terukazu Enami;Kenichi Yoshida;Yuichi Shiraishi.
Nature Genetics (2014)
Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells
Keiki Kumano;Shigeru Chiba;Atsushi Kunisato;Masataka Sata.
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Masashi Sanada;Takahiro Suzuki;Lee-Yung Shih;Makoto Otsu.
The oncoprotein Evi-1 represses TGF-Beta signalling by inhibiting Smad3
Mineo Kurokawa;Kinuko Mitani;Kenji Irie;Tomohiro Matsuyama.
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