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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
19276
World Ranking
4385
National Ranking
149

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Richard Béliveau is affiliated with the University of Quebec at Montreal in Canada. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions to Molecular Biology, Cancer Research, Oncology, Immunology, and Radiology, Nuclear Medicine, and Imaging.

Their recent publications reflect a concentration on peptide-drug conjugates targeting cancer, particularly exploring therapeutics involving the sortilin receptor. Notable papers include:

  • TH1902, a new docetaxel-peptide conjugate for the treatment of sortilin-positive triple-negative breast cancer (2021, Cancer Science)
  • The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers (2022, Cancers)
  • New Peptide-Drug Conjugates for Precise Targeting of SORT1-Mediated Vasculogenic Mimicry in the Tumor Microenvironment of TNBC-Derived MDA-MB-231 Breast and Ovarian ES-2 Clear Cell Carcinoma Cells (2021, Frontiers in Oncology)
  • The TH1902 Docetaxel Peptide-Drug Conjugate Inhibits Xenografts Growth of Human SORT1-Positive Ovarian and Triple-Negative Breast Cancer Stem-like Cells (2022, Pharmaceutics)
  • Sudocetaxel Zendusortide (TH1902) triggers the cGAS/STING pathway and potentiates anti-PD-L1 immune-mediated tumor cell killing (2024, Frontiers in Immunology)

Richard Béliveau frequently publishes in venues such as:

  • Cancer Research
  • Frontiers in Immunology
  • Cancer Science
  • Cancers
  • Frontiers in Oncology

Frequent collaborators in their research include Michel Demeule, Alain Zgheib, Christian Marsolais, Borhane Annabi, and Jean-Christophe Currie. This collaboration network highlights a consistent team-based approach in cancer research and molecular therapeutics development.

The primary research topics addressed in their work cover:

  • RNA Research and Splicing
  • Cancer, Lipids, and Metabolism
  • RNA Interference and Gene Delivery
  • Interferon and Immune Responses
  • Ubiquitin and Proteasome Pathways
  • Protein Degradation and Inhibitors
  • Angiogenesis and VEGF in Cancer

These topics underscore an interrelated focus on molecular mechanisms involved in cancer biology, immune signaling pathways, and targeted therapeutic strategies. The integration of peptide-drug conjugate technology in their research suggests efforts toward precision medicine approaches in oncology.

Best Publications

  • Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2.

    Michel Demeule;Jean-Christophe Currie;Yanick Bertrand;Christian Ché

  • Matrix metalloproteinase inhibition by green tea catechins.

    Michel Demeule;Mathieu Brossard;Martine Pagé;Denis Gingras

  • Identification and Design of Peptides as a New Drug Delivery System for the Brain

    Michel Demeule;Anthony Régina;Christian Ché;Julie Poirier

  • Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2.

    Régina A;Demeule M;Ché C;Lavallée I

  • Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols.

    Julie Jodoin;Michel Demeule;Michel Demeule;Richard Béliveau;Richard Béliveau

  • Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation.

    Borhane Annabi;Ying‐Ta Lee;Sandra Turcotte;Emmanuelle Naud

  • Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.

    Lyne Labrecque;Isabelle Royal;David S. Surprenant;W. Cam Patterson

  • P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain.

    Édith Beaulieu;Michel Demeule;Lucian Ghitescu;Richard Béliveau

  • Green Tea Catechins Inhibit Vascular Endothelial Growth Factor Receptor Phosphorylation

    Sylvie Lamy;Denis Gingras;Richard Béliveau

  • Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.

    Michel Demeule;Anthony Régina;Julie Jodoin;Alain Laplante

  • Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice.

    Dominique Boivin;Mélanie Blanchette;Stéphane Barrette;Albert Moghrabi

  • High transcytosis of melanotransferrin (P97) across the blood-brain barrier.

    Michel Demeule;Julie Poirier;Julie Jodoin;Yanick Bertrand

  • Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes.

    Marie-Annick Forget;Richard R. Desrosiers;Denis Gingras;Richard Béliveau

  • Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells.

    Borhane Annabi;Marie Paule Lachambre;Nathalie Bousquet-Gagnon;Martine Page

  • Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts.

    Marie-Claude Perry;Michel Demeule;Anthony Régina;Robert Moumdjian

  • Propranolol suppresses angiogenesis in vitro: inhibition of proliferation, migration, and differentiation of endothelial cells.

    Sylvie Lamy;Marie-Paule Lachambre;Simon Lord-Dufour;Richard Béliveau

  • P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries

    Michel Demeule;Michel Demeule;Julie Jodoin;Julie Jodoin;Denis Gingras;Denis Gingras;Richard Béliveau;Richard Béliveau

  • Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration

    Jonathan Michaud-Levesque;Nathalie Bousquet-Gagnon;Richard Béliveau

  • Expression of matrix metalloproteinases and their inhibitors in human brain tumors.

    Kachra Z;Beaulieu E;Delbecchi L;Mousseau N

  • Physiological roles of matrix metalloproteinases: implications for tumor growth and metastasis.

    Marie-Annick Forget;Richard R Desrosiers;Richard Béliveau

Frequent Co-Authors

Jacques Galipeau
Jacques Galipeau University of Wisconsin–Madison
Gillian Murphy
Gillian Murphy University of Cambridge
Yves Durocher
Yves Durocher National Academies of Sciences, Engineering, and Medicine
Danica Stanimirovic
Danica Stanimirovic National Research Council Canada
Roméo Cecchelli
Roméo Cecchelli Artois University
Robert E. Hawkins
Robert E. Hawkins University of Manchester
Pavel Hamet
Pavel Hamet University of Montreal
Philippe Sarret
Philippe Sarret Université de Sherbrooke
Christopher F. Higgins
Christopher F. Higgins Hammersmith Hospital
Daniel Bélanger
Daniel Bélanger University of Quebec at Montreal

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