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Nicola Silvestris

Nicola Silvestris

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
12206
World Ranking
9357
National Ranking
257

Overview

Nicola Silvestris is affiliated with the University of Messina in Italy and has contributed extensively to the fields of medicine and molecular biology, with a particular focus on oncology.

Their research spans a variety of subfields, including oncology, molecular biology, cancer research, immunology, and pulmonary and respiratory medicine. Key topics of their work encompass cancer immunotherapy and biomarkers, pancreatic and hepatic oncology research, COVID-19 clinical research studies, SARS-CoV-2 and COVID-19 research, cancer genomics and diagnostics, colorectal cancer treatments and studies, and immunotherapy and immune responses.

Recent significant papers authored or co-authored by Nicola Silvestris include:

  • Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial, 2020, The Lancet Oncology
  • Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples, 2020, Journal of Experimental & Clinical Cancer Research
  • Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study, 2020, Annals of Translational Medicine
  • Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death, 2020, Cancers
  • Combination of Ipilimumab and Nivolumab in Cancers: From Clinical Practice to Ongoing Clinical Trials, 2020, International Journal of Molecular Sciences

Nicola Silvestris has collaborated frequently with several co-authors, including:

  • Oronzo Brunetti
  • Afshin Derakhshani
  • Antonella Argentiero
  • Behzad Baradaran
  • Vito Racanelli

Publications by Nicola Silvestris appear regularly in various scientific venues, notably:

  • Frontiers in Oncology
  • Cancers
  • Preprints.org
  • ESMO Open
  • International Journal of Molecular Sciences

Their academic output reflects contributions to cancer immunotherapy and biomarker discovery, as well as oncological studies on pancreatic, hepatic, and colorectal cancers, alongside research related to the COVID-19 pandemic. The integration of clinical trials and translational research is seen in their publications, which cover treatment protocols and molecular diagnostic approaches.

Best Publications

  • Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples

    Marco Russano;Andrea Napolitano;Giulia Ribelli;Michele Iuliani

  • Plasma-activated medium triggers cell death and the presentation of immune activating danger signals in melanoma and pancreatic cancer cells.

    Amalia Azzariti;Rosa Maria Iacobazzi;Roberta Di Fonte;Letizia Porcelli

  • Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study

    D. Santini;M. Tampellini;B. Vincenzi;T. Ibrahim

  • Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study.

    Jin-Feng Huang;Jianfei Shen;Xiao Li;Ramesh Rengan

  • Hospital admission of cancer patients: avoidable practice or necessary care?

    Gianmauro Numico;Antonella Cristofano;Alessandro Mozzicafreddo;Olga Elisabetta Cursio

  • Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?

    Sergio Rizzo;Giuseppe Bronte;Daniele Fanale;Lidia Corsini

  • Current approaches for combination therapy of cancer: The role of immunogenic cell death

    Zahra Asadzadeh;Elham Safarzadeh;Sahar Safaei;Ali Baradaran

  • Dasatinib: an anti-tumour agent via Src inhibition.

    Antonio Gnoni;Ilaria Marech;Nicola Silvestris;Angelo Vacca

  • The role of inflammatory cytokines and tumor associated macrophages (TAMs) in microenvironment of pancreatic cancer.

    Saeed Farajzadeh Valilou;Mahsa Keshavarz-Fathi;Mahsa Keshavarz-Fathi;Nicola Silvestris;Antonella Argentiero

  • Expression and prognostic value of VEGFR-2, PDGFR-β, and c-Met in advanced hepatocellular carcinoma

    Jie Sheng Chu;Fei Jiao Ge;Bo Zhang;Yan Wang

  • Adjuvant colon cancer chemotherapy: where we are and where we'll go.

    L. Lombardi;F. Morelli;S. Cinieri;D. Santini

  • Human epidermal growth factor receptor 2 (HER2) in gastric cancer: a new therapeutic target.

    F. De Vita;F. Giuliani;N. Silvestris;G. Catalano

  • Immunotherapy for colorectal cancer: where are we heading?

    Debora Basile;Silvio Ken Garattini;Marta Bonotto;Elena Ongaro

  • High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression.

    Andrea Malfettone;Nicola Silvestris;Concetta Saponaro;Girolamo Ranieri

  • Immune inflammation indicators and implication for immune modulation strategies in advanced hepatocellular carcinoma patients receiving sorafenib

    Andrea Casadei Gardini;Emanuela Scarpi;Luca Faloppi;Mario Scartozzi

  • Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

    Vito Longo;Oronzo Brunetti;Antonio Gnoni;Stefano Cascinu

  • Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study.

    Antonella Argentiero;Simona De Summa;Roberta Di Fonte;Rosa Maria Iacobazzi

  • New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?

    Giuseppe Bronte;Nicola Silvestris;Marta Castiglia;Antonio Galvano

  • Molecularly targeted endocrine therapies for breast cancer.

    L. Orlando;P. Schiavone;P. Fedele;N. Calvani

  • Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale.

    Andrea Casadei Gardini;Luca Faloppi;Serena De Matteis;Francesco Giuseppe Foschi

Frequent Co-Authors

Daniele Santini
Daniele Santini Università Campus Bio-Medico
Behzad Baradaran
Behzad Baradaran Tabriz University of Medical Sciences
Stefano Cascinu
Stefano Cascinu Vita-Salute San Raffaele University
Antonio Russo
Antonio Russo University of Palermo
Angelo Paradiso
Angelo Paradiso National Cancer Research Institute, UK
Giuseppe Tonini
Giuseppe Tonini Università Campus Bio-Medico
Bruno Vincenzi
Bruno Vincenzi Università Campus Bio-Medico
Sara Lonardi
Sara Lonardi Istituto Oncologico Veneto
Aldo Scarpa
Aldo Scarpa University of Verona
Angelo Vacca
Angelo Vacca University of Bari Aldo Moro

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