D-Index & Metrics Best Publications
Masaji Ohno

Masaji Ohno

University of Tokyo
Japan

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Enzyme
  • Catalysis

Masaji Ohno mainly investigates Stereochemistry, Organic chemistry, Enantioselective synthesis, Asymmetric induction and Medicinal chemistry. His work in Stereochemistry covers topics such as DNA which are related to areas like Mechanism of action. In general Organic chemistry, his work in Alkylation, Acetal, Esterase and Synthon is often linked to Fluoride linking many areas of study.

Enantioselective synthesis is a subfield of Catalysis that Masaji Ohno studies. The various areas that he examines in his Asymmetric induction study include Diethylzinc, Toluene and Combinatorial chemistry. The concepts of his Medicinal chemistry study are interwoven with issues in Chiral ligand and Lewis acids and bases.

His most cited work include:

  • Stereocontrolled synthesis of (+)-negamycin from an acyclic homoallylamine by 1,3-asymmetric induction (226 citations)
  • A catalytic enantioselective reaction using a C2-symmetric disulfonamide as a chiral ligand: Alkylation of aldehydes catalyzed by disulfonamide-Ti(O-i-Pr)4-Dialkyl zinc system (207 citations)
  • Asymmetric induction catalyzed by conjugate bases of chiral proton acids as ligands: enantioselective addition of dialkylzinc-orthotitanate complex to benzaldehyde with catalytic ability of a remarkable high order (158 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Stereochemistry, Organic chemistry, Enantioselective synthesis, Total synthesis and Hydrolysis. His work in Stereochemistry addresses subjects such as Binding site, which are connected to disciplines such as Transition metal. His study on Catalysis, Synthon, Alkyl and Reagent is often connected to Fluoride as part of broader study in Organic chemistry.

His study in the fields of Chiral ligand under the domain of Enantioselective synthesis overlaps with other disciplines such as Aminocyclitol. His Retrosynthetic analysis study, which is part of a larger body of work in Total synthesis, is frequently linked to Rhizoxin, bridging the gap between disciplines. Masaji Ohno has researched Hydrolysis in several fields, including Esterase and Enzyme.

He most often published in these fields:

  • Stereochemistry (60.51%)
  • Organic chemistry (28.72%)
  • Enantioselective synthesis (16.41%)

What were the highlights of his more recent work (between 1988-2010)?

  • Stereochemistry (60.51%)
  • Organic chemistry (28.72%)
  • Enantioselective synthesis (16.41%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Stereochemistry, Organic chemistry, Enantioselective synthesis, Catalysis and Stereoselectivity. He combines subjects such as Glycosylation and Binding site with his study of Stereochemistry. His work on Carboxylic acid and Thioester as part of general Organic chemistry study is frequently connected to Fluoride, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.

His Enantioselective synthesis research is multidisciplinary, incorporating elements of Hydrolysis, Esterase, Aldehyde and Synthon. His Catalysis research integrates issues from Combinatorial chemistry, Reagent and Gallium. His Moiety study incorporates themes from Yield, Metal Binding Site, DNA, Enzyme and Fortimicin A.

Between 1988 and 2010, his most popular works were:

  • A catalytic enantioselective reaction using a C2-symmetric disulfonamide as a chiral ligand: Alkylation of aldehydes catalyzed by disulfonamide-Ti(O-i-Pr)4-Dialkyl zinc system (207 citations)
  • Asymmetric induction catalyzed by conjugate bases of chiral proton acids as ligands: enantioselective addition of dialkylzinc-orthotitanate complex to benzaldehyde with catalytic ability of a remarkable high order (158 citations)
  • Enantioselective alkylation of aldehyde catalyzed by disulfonamide-Ti(O-i-Pr)4-dialkyl zinc system (132 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Enzyme
  • Catalysis

Organic chemistry, Enantioselective synthesis, Stereochemistry, Catalysis and Aldehyde are his primary areas of study. His Enantioselective synthesis research includes elements of Medicinal chemistry, Lewis acids and bases and Synthon. His work carried out in the field of Synthon brings together such families of science as Hydrolysis and Esterase.

The Stereochemistry study combines topics in areas such as DNA and Stereoselectivity. His biological study spans a wide range of topics, including Reagent and Glycoside. The Aldehyde study which covers Aliphatic compound that intersects with Hexanal and Zinc.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Stereocontrolled synthesis of (+)-negamycin from an acyclic homoallylamine by 1,3-asymmetric induction

Yi Fong Wang;Toshio Izawa;Susumu Kobayashi;Masaji Ohno.
Journal of the American Chemical Society (1982)

372 Citations

A catalytic enantioselective reaction using a C2-symmetric disulfonamide as a chiral ligand: Alkylation of aldehydes catalyzed by disulfonamide-Ti(O-i-Pr)4-Dialkyl zinc system

Hideyo Takahashi;Takashi Kawakita;Masaji Ohno;Masato Yoshioka.
Tetrahedron (1992)

359 Citations

Asymmetric induction catalyzed by conjugate bases of chiral proton acids as ligands: Enantioselective addition of dialkylzinc-orthotitanate complex to benzaldehyde with catalytic ability of a remarkable high order

Masato Yoshioka;Takashi Kawakita;Masaji Ohno.
Tetrahedron Letters (1989)

275 Citations

Enantioselective synthesis of the carbocyclic nucleosides (-)-aristeromycin and (-)-neplanocin A by a chemicoenzymatic approach

Masafumi Arita;Kunitomo Adachi;Yukishige Ito;Hiroaki Sawai.
Journal of the American Chemical Society (1983)

239 Citations

Enantioselective alkylation of aldehyde catalyzed by disulfonamide-Ti(O-i-Pr)4-dialkyl zinc system

Hideyo Takahashi;Takashi Kawakita;Masato Yoshioka;Susumu Kobayashi.
Tetrahedron Letters (1989)

210 Citations

Ph3P-(PyS)2-CH3CN as an excellent condensing system for .beta.-lactam formation from .beta.-amino acids

Susumu Kobayashi;Takamasa Iimori;Toshio Izawa;Masaji Ohno.
Journal of the American Chemical Society (1981)

180 Citations

Man-designed bleomycin with altered sequence specificity in DNA cleavage

Masami Otsuka;Takeshi Masuda;Andreas Haupt;Masaji Ohno.
Journal of the American Chemical Society (1990)

153 Citations

SYNTHESIS OF (S)- AND (R)-4((METHOXYCARBONYL)METHYL)-2-AZETIDINONE BY CHEMICOENZYMIC APPROACH

Masaji Ohno;Susumu Kobayashi;Takamasa Iimori;Yi-Fong Wang.
Journal of the American Chemical Society (1981)

145 Citations

Negamycin, a novel hydrazide antibiotic.

Shinichi Kondo;Seiji Shibahara;Shuji Takahashi;Kenji Maeda.
Journal of the American Chemical Society (1971)

133 Citations

Creation of novel chiral synthons with enzymes and applications to natural product synthesis. 15. Efficient introduction of chiral centers into cyclohexane ring

Susumu Kobayashi;Keiji Kamiyama;Takamasa Iimori;Masaji Ohno.
Tetrahedron Letters (1984)

120 Citations

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