World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
37
Citations
7341
World Ranking
8717
National Ranking
3697

Overview

Mahesh M. Thakkar is affiliated with the University of Missouri in the United States and has made contributions primarily in the fields of Neuroscience and Medicine. Their research has a notable focus on sleep-related topics, circadian rhythms, and neurobiological mechanisms associated with memory and brain function.

Their main fields of study include:

  • Neuroscience
  • Medicine

Within these fields, Thakkar's work spans multiple subfields such as:

  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Physiology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

The research topics they have addressed cover a range of areas related to sleep and brain function, including:

  • Sleep and related disorders
  • Sleep and Wakefulness Research
  • Circadian rhythm and melatonin
  • Memory and Neural Mechanisms
  • Obstructive Sleep Apnea Research
  • Dietary Effects on Health
  • Neuroscience and Neuropharmacology Research

Thakkar has published extensively in journals focused on sleep and neurobiology. The frequent publication venues associated with their work are:

  • SLEEP
  • Alcoholism Clinical and Experimental Research
  • Neuroscience
  • JCI Insight
  • Brain Research Bulletin

Some of the recent papers by Thakkar and coauthors include:

  • "Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary" (2020, JCI Insight)
  • "Sleep, sleep homeostasis and arousal disturbances in alcoholism" (2022, Brain Research Bulletin)
  • "Short-term sleep deprivation immediately after contextual conditioning inhibits BDNF signaling and disrupts memory consolidation in predator odor trauma mice model of PTSD" (2020, Brain Research)
  • "Chronic alcohol exposure reduces acetylated histones in the sleep-wake regulatory brain regions to cause insomnia during withdrawal" (2020, Neuropharmacology)
  • "Antisense-Induced Downregulation of Clock Genes in the Shell Region of the Nucleus Accumbens Reduces Binge Drinking in Mice" (2021, Alcoholism Clinical and Experimental Research)

Their frequent co-authors include:

  • Pradeep Sahota
  • Meet Parikh
  • Rishi Sharma
  • Abigail Chischolm

Overall, Mahesh M. Thakkar's research portfolio reflects a sustained engagement with understanding the neurobiological basis of sleep, its disorders, and its interactions with other physiological and cognitive processes.

Best Publications

  • Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness.

    Tarja Porkka-Heiskanen;Robert E. Strecker;Mahesh Thakkar;Alvhild A. Bjørkum

  • Adenosine and sleep–wake regulation

    Radhika Basheer;Robert E. Strecker;Mahesh M. Thakkar;Robert W. McCarley

  • Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state

    Robert E Strecker;Stephen Morairty;Mahesh M Thakkar;Tarja Porkka-Heiskanen

  • Alcohol disrupts sleep homeostasis.

    Mahesh M. Thakkar;Mahesh M. Thakkar;Rishi Sharma;Rishi Sharma;Pradeep Sahota;Pradeep Sahota

  • Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat

    CM Portas;M Thakkar;D Rainnie;RW McCarley

  • Histamine in the regulation of wakefulness

    Mahesh M. Thakkar

  • Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation

    Jaime L. Tartar;Christopher P. Ward;Christopher P. Ward;James T. McKenna;Mahesh Thakkar

  • Role of adenosine in behavioral state modulation: A microdialysis study in the freely moving cat

    C. M. Portas;M. Thakkar;D. G. Rainnie;Robert Greene

  • Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary.

    Jeffrey A. Haspel;Ron Anafi;Marishka K. Brown;Nicolas Cermakian

  • Behavioral State Control through Differential Serotonergic Inhibition in the Mesopontine Cholinergic Nuclei: A Simultaneous Unit Recording and Microdialysis Study

    Mahesh M. Thakkar;Robert E. Strecker;Robert W. McCarley

  • A1 Receptor and Adenosinergic Homeostatic Regulation of Sleep-Wakefulness: Effects of Antisense to the A1 Receptor in the Cholinergic Basal Forebrain

    Mahesh M. Thakkar;Stuart Winston;Robert W. McCarley

  • Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.

    M. M. Thakkar;V. Ramesh;R. E. Strecker;R. W. McCarley

  • Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness.

    J.T. McKenna;J.L. Tartar;C.P. Ward;M.M. Thakkar

  • Adenosine and the homeostatic control of sleep: effects of A1 receptor blockade in the perifornical lateral hypothalamus on sleep-wakefulness

    M.M. Thakkar;S.C. Engemann;K.M. Walsh;P.K. Sahota

  • Adenosine as a biological signal mediating sleepiness following prolonged wakefulness.

    Radhika Basheer;Tarja Porkka-Heiskanen;Robert E. Strecker;Mahesh M. Thakkar

  • Compensatory sleep response to 12 h wakefulness in young and old rats.

    Priyattam J. Shiromani;Jun Lu;Dean Wagner;Jolleyin Thakkar

  • Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep–wakefulness and prolonged wakefulness: An in vivo microdialysis study

    R.E Strecker;J Nalwalk;L.J Dauphin;M.M Thakkar

  • Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice.

    Ritchie E. Brown;James T. McKenna;Stuart Winston;Radhika Basheer

  • Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving cats.

    M.M Thakkar;R.A Delgiacco;R.E Strecker;R.W McCarley

  • Chronic low-amplitude electrical stimulation of the laterodorsal tegmental nucleus of freely moving cats increases REM sleep

    Mahesh Thakkar;Chiara Portas;Robert W. McCarley

Frequent Co-Authors

Robert W. McCarley
Robert W. McCarley Harvard Medical School
Robert E. Strecker
Robert E. Strecker VA Boston Healthcare System
Tarja Porkka-Heiskanen
Tarja Porkka-Heiskanen University of Helsinki
Ritchie E. Brown
Ritchie E. Brown Harvard University
Donald G. Rainnie
Donald G. Rainnie Emory University
Robert W. Greene
Robert W. Greene The University of Texas Southwestern Medical Center
Adrian R. Morrison
Adrian R. Morrison University of Pennsylvania
Priyattam J. Shiromani
Priyattam J. Shiromani Veterans Health Administration
Larry D. Sanford
Larry D. Sanford Eastern Virginia Medical School
Vijaya Ramesh
Vijaya Ramesh Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Mahesh M. Thakkar

Trending Scientists