World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
42
Citations
7726
World Ranking
17435
National Ranking
4274

Overview

Joseph E. Saavedra is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on the field of Medicine, with specific contributions in Surgery, Oncology, Rheumatology, Electrical and Electronic Engineering, and Bioengineering.

The scientist's work intersects multiple topics, including anorectal disease treatments and outcomes, colorectal cancer surgical treatments, pelvic floor disorders treatments, gas sensing nanomaterials and sensors, analytical chemistry and sensors, and silicone and siloxane chemistry. This multidisciplinary approach reflects a blend of clinical and material science expertise.

Saavedra has published research in several academic venues. Notably, they have contributed to the following journals:

  • Colorectal Disease
  • UNC Libraries

Some of their recent papers include:

  • Optimizing sacral neuromodulation for low anterior resection syndrome: learning from our experience, 2020, Colorectal Disease
  • O2-Protected diazeniumdiolate-modified silica nanoparticles for extended nitric oxide release from dental composites, 2020, UNC Libraries

Frequent collaborators in their research comprise the following individuals:

  • Inés Rubio-Pérez
  • J. L. Marijuan
  • Isabel Pascual
  • Alexis W. Carpenter
  • Katelyn P. Reighard

Best Publications

  • Complexes of 'NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide. Vasorelaxant Effects

    Chris M. Maragos;Deborah Morley;David A. Wink;Tambra M. Dunams

  • Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction.

    David A. Wink;John F. Darbyshire;Raymond W. Nims;Joseph E. Saavedra

  • Preparation and characterization of hydrophobic polymeric films that are thromboresistant via nitric oxide release

    Kelly A. Mowery;Mark H. Schoenfisch;Joseph E. Saavedra;Larry K. Keefer

  • Measuring fifteen endogenous estrogens simultaneously in human urine by high-performance liquid chromatography-mass spectrometry.

    Xia Xu;Timothy D Veenstra;Stephen D Fox;John M Roman

  • Nitric Oxide-Releasing Polymers Containing the (N(O)NO) - Group

    Daniel J. Smith;Debashish Chakravarthy;Sharon Pulfer;Maia L. Simmons

  • Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic.

    Jie Liu;Hua Chen;David S. Miller;Joseph E. Saavedra

  • JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.

    Paul J. Shami;Joseph E. Saavedra;Lai Y. Wang;Challice L. Bonifant

  • Esterase-sensitive nitric oxide donors of the diazeniumdiolate family: in vitro antileukemic activity.

    Joseph E. Saavedra;Paul J. Shami;Lai Yi Wang;Keith M. Davies

  • Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia.

    Junhai Ou;Timothy M. Carlos;Simon C. Watkins;Joseph E. Saavedra

  • Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.

    Katrina M. Miranda;Tatsuo Katori;Claudia L. Torres De Holding;Lynta Thomas

  • Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo.

    Paul J. Shami;Joseph E. Saavedra;Challice L. Bonifant;Jingxi Chu

  • Tumor Cell Responses to a Novel Glutathione S-Transferase–Activated Nitric Oxide-Releasing Prodrug

    Victoria J. Findlay;Danyelle M. Townsend;Joseph E. Saavedra;Gregory S. Buzard

  • Colorimetric Methods for the Determination of Nitric Oxide Concentration in Neutral Aqueous Solutions

    Raymond W. Nims;John F. Darbyshire;Joseph E. Saavedra;Danae Christodoulou

  • Nitric oxide and nanotechnology: a novel approach to inhibit neointimal hyperplasia.

    Muneera R. Kapadia;Lesley W. Chow;Nick D. Tsihlis;Sadaf S. Ahanchi

  • Chemistry of the diazeniumdiolates. I. Structural and spectral characteristics of the [N(O)NO]- functional group.

    L K Keefer;J L Flippen-Anderson;C George;A P Shanklin

  • A Glutathione S-Transferase π-Activated Prodrug Causes Kinase Activation Concurrent with S-Glutathionylation of Proteins

    Danyelle M. Townsend;Victoria J. Findlay;Farit Fazilev;Molly Ogle

  • The Secondary Amine/Nitric Oxide Complex Ion R2N[N(O)NO]- as Nucleophile and Leaving Group in SNAr Reactions

    Joseph E. Saavedra;Aloka Srinivasan;Challice L. Bonifant;Jingxi Chu

  • The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice.

    Jie Liu;Chengxiu Li;Michael P. Waalkes;James Clark

  • Secondary amine/nitric oxide complex ions, R2N[N(O)NO]-. O-functionalization chemistry

    Joseph E. Saavedra;Tambra M. Dunams;Judith L. Flippen-Anderson;Larry K. Keefer

  • HNO and NO Release from a Primary Amine-Based Diazeniumdiolate As a Function of pH

    Debra J. Salmon;Claudia L. Torres de Holding;Lynta Thomas;Kyle V. Peterson

Frequent Co-Authors

Larry K. Keefer
Larry K. Keefer Science Applications International Corporation (United States)
Michael P. Waalkes
Michael P. Waalkes National Institutes of Health
Xinhua Ji
Xinhua Ji National Institutes of Health
Judith L. Flippen-Anderson
Judith L. Flippen-Anderson United States Naval Research Laboratory
David A. Wink
David A. Wink National Institutes of Health
Haleem J. Issaq
Haleem J. Issaq National Cancer Institute
Jie Liu
Jie Liu National Institutes of Health
Kenneth D. Tew
Kenneth D. Tew Medical University of South Carolina
Timothy D. Veenstra
Timothy D. Veenstra Lake Erie College of Osteopathic Medicine
Danyelle M. Townsend
Danyelle M. Townsend Medical University of South Carolina

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Chemistry in the USA opens the door to various specialized online degrees and career options. For those seeking foundational education, exploring the best online criminal justice associate degree programs can provide insight into how structured remote learning is. While this degree focuses on criminal justice, understanding the costs and investment involved is crucial, and resources like how much is criminal justice school offer valuable tuition and fees breakdowns.

For those interested in the legal sector related to chemical regulations and intellectual property, a paralegal certificate can be a practical credential to advance your career. Meanwhile, chemistry graduates often consider roles that blend science with business, such as pharmaceutical sales. Learning from guides on pharmaceutical sales rep salary and career paths can help map out potential earnings and growth opportunities.

Overall, diversifying your skillset through related online degrees or certifications can enhance job prospects and ensure a versatile career path aligned with your chemistry background.

Best Scientists Citing Joseph E. Saavedra

Trending Scientists