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D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
21760
World Ranking
18178
National Ranking
7429

Overview

John C. Castle is affiliated with Monte Rosa Therapeutics in the United States. Their research spans several areas within medicine, with a focus on molecular biology, epidemiology, public health, oncology, and parasitology.

Their recent publications cover a range of topics and include the following papers:

  • Abstract 3929: Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational addiction, 2022, Cancer Research
  • Current status of use of high throughput nucleotide sequencing in rheumatology, 2021, RMD Open
  • The characteristics of men who have sex with men with Blastocystis: A systematic review, 2025, International Journal of STD & AIDS
  • An evaluation of clinical fellow programmes in an acute teaching hospital trust, 2023, British Journal of Hospital Medicine
  • Molecular surface mimicry enables CRBN to target G3BP2 for degradation, 2025, bioRxiv (Cold Spring Harbor Laboratory)

The frequent coauthors associated with John C. Castle include:

  • Débora Bonenfant
  • Vladislav Zarayskiy
  • Bernhard Fasching
  • Daniel Richardson
  • Gérald Gavory

John C. Castle's work has been published in various venues, primarily in:

  • Cancer Research
  • International Journal of STD & AIDS
  • British Journal of Hospital Medicine
  • RMD Open
  • bioRxiv (Cold Spring Harbor Laboratory)

Their research fields include:

  • Medicine

With subfields covering:

  • Molecular Biology
  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Oncology
  • Parasitology

Main topics of John C. Castle's research encompass:

  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Peptidase Inhibition and Analysis
  • Parasitic Infections and Diagnostics
  • Breastfeeding Practices and Influences
  • Innovations in Medical Education
  • Hospital Admissions and Outcomes

Best Publications

  • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

    Lee P. Lim;Nelson C. Lau;Philip Garrett-Engele;Andrew Grimson

  • Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.

    Jason M. Johnson;John Castle;Philip Garrett-Engele;Zhengyan Kan

  • Mutant MHC class II epitopes drive therapeutic immune responses to cancer

    Sebastian Kreiter;Mathias Vormehr;Niels van de Roemer;Mustafa Diken

  • An integrative genomics approach to infer causal associations between gene expression and disease

    Eric E Schadt;John Lamb;Xia Yang;Jun Zhu

  • Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

    Honglin Zhou;Min Xu;Qian Huang;Adam T. Gates

  • Exploiting the mutanome for tumor vaccination

    John C. Castle;Sebastian Kreiter;Jan Diekmann;Martin Löwer

  • Actively personalized vaccination trial for newly diagnosed glioblastoma

    Norbert Hilf;Sabrina Kuttruff-Coqui;Katrin Frenzel;Valesca Bukur

  • Experimental annotation of the human genome using microarray technology

    D. D. Shoemaker;E. E. Schadt;C. D. Armour;Y. D. He

  • A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

    Auinash Kalsotra;Xinshu Xiao;Amanda J. Ward;John C. Castle

  • Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2

    Juan I. Young;Eugene P. Hong;John C. Castle;Juan Crespo-Barreto

  • Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

    John C Castle;Martin Loewer;Sebastian Boegel;Jos de Graaf

  • Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines.

    John C Castle;Chaolin Zhang;Jyoti K Shah;Amit V Kulkarni

  • Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2

    Chaolin Zhang;Zuo Zhang;John Castle;Shuying Sun;Shuying Sun

  • Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition.

    K Bleasby;J C Castle;C J Roberts;C Cheng

  • Unique Signatures of Long Noncoding RNA Expression in Response to Virus Infection and Altered Innate Immune Signaling

    Xinxia Peng;Lisa Gralinski;Christopher D. Armour;Martin T Ferris

  • HLA typing from RNA-Seq sequence reads

    Sebastian Boegel;Martin Löwer;Michael Schäfer;Thomas Bukur

  • Digital transcriptome profiling using selective hexamer priming for cDNA synthesis.

    Christopher D Armour;John C Castle;Ronghua Chen;Tomas Babak

  • Comparative expression pathway analysis of human and canine mammary tumors

    Paolo Uva;Luigi Aurisicchio;James Watters;Andrey Loboda

  • Definition, conservation and epigenetics of housekeeping and tissue-enriched genes

    Xinwei She;Carol A Rohl;John C Castle;Amit V Kulkarni

  • Individual-specific variation of gene expression in peripheral blood leukocytes.

    Jerald P. Radich;Mao Mao;Sergey Stepaniants;Matt Biery

Frequent Co-Authors

Ugur Sahin
Ugur Sahin Johannes Gutenberg University of Mainz
Özlem Türeci
Özlem Türeci BioNTech (Germany)
Hans-Georg Rammensee
Hans-Georg Rammensee University of Tübingen
Wolfgang Wick
Wolfgang Wick German Cancer Research Center
Andreas von Deimling
Andreas von Deimling Heidelberg University
Per thor Straten
Per thor Straten University of Copenhagen
Eric E. Schadt
Eric E. Schadt Icahn School of Medicine at Mount Sinai
David Capper
David Capper Charité - University Medicine Berlin
Christoph Huber
Christoph Huber BioNTech (Germany)
Arie Admon
Arie Admon Technion – Israel Institute of Technology

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