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Biology and Biochemistry

D-Index
70
Citations
23396
World Ranking
6888
National Ranking
3175

Overview

Jerry S. Lanchbury is affiliated with Myriad in the United States and has a research focus situated primarily within biochemistry, genetics, and molecular biology, with additional work in medicine. Their scholarly output spans multiple subfields including genetics, oncology, cancer research, molecular biology, and pulmonary and respiratory medicine.

Their published research addresses a range of topics, with notable emphasis on BRCA gene mutations in cancer, nutrition, genetics, and disease, PARP inhibition in cancer therapy, genetic associations and epidemiology, DNA repair mechanisms, genomic variations and chromosomal abnormalities, as well as cancer genomics and diagnostics.

Among their recent publications are the following papers:

  • Association of a Polygenic Risk Score With Breast Cancer Among Women Carriers of High- and Moderate-Risk Breast Cancer Genes, 2020, JAMA Network Open
  • Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer, 2021, Modern Pathology
  • Development and Validation of a Clinical Polygenic Risk Score to Predict Breast Cancer Risk, 2020, JCO Precision Oncology
  • Modification of Homologous Recombination Deficiency Score Threshold and Association with Long-Term Survival in Epithelial Ovarian Cancer, 2021, Cancers
  • Performance of the IBIS/Tyrer-Cuzick model of breast cancer risk by race and ethnicity in the Women's Health Initiative, 2021, Cancer

Frequent co-authorship includes collaborations with Alexander Gutin, Elisha Hughes, Susanne Wagner, Allison W. Kurian, and Susan M. Domchek, reflecting sustained research partnerships across multiple projects.

Lanchbury's work is often published in established scientific journals, with multiple contributions to the Journal of Clinical Oncology, Cancer Research, JCO Precision Oncology, Annals of the Rheumatic Diseases, and Clinical Cancer Research. These venues highlight a focus on clinical and translational cancer research alongside genetic and molecular studies.

Best Publications

  • The genome of the domesticated apple ( Malus × domestica Borkh.)

    Riccardo Velasco;Andrey Zharkikh;Jason Affourtit;Amit Dhingra

  • A High Quality Draft Consensus Sequence of the Genome of a Heterozygous Grapevine Variety

    Riccardo Velasco;Andrey Zharkikh;Michela Troggio;Dustin A. Cartwright

  • Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.

    Melinda L. Telli;Kirsten M. Timms;Julia Reid;Bryan Hennessy

  • Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study.

    Jack Cuzick;Gregory P Swanson;Gabrielle Fisher;Arthur R Brothman

  • Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: The TNT Trial

    Andrew Tutt;Andrew Tutt;Holly Tovey;Maggie Chon U Cheang;Sarah Kernaghan

  • Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

    Victor Abkevich;Kirsten Timms;Bryan T. Hennessy;Jennifer Potter

  • The importance of the t cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis

    G. S. Panayi;J. S. Lanchbury;G. H. Kingsley

  • Incidence and Outcome of BRCA Mutations in Unselected Patients with Triple Receptor-Negative Breast Cancer

    Ana M. Gonzalez-Angulo;Kirsten M. Timms;Shuying Liu;Huiqin Chen

  • SINGLE NUCLEOTIDE POLYMORPHISMS AND THE FUTURE OF GENETIC EPIDEMIOLOGY

    Nicholas J Schork;Daniele Fallin;Jerry S Lanchbury

  • Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms.

    M. H. Thornhill;S. M. Wellicome;D. L. Mahiouz;J. S. S. Lanchbury

  • Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis

    Francesca Capon;Paola Di Meglio;Joanna Szaub;Natalie J. Prescott

  • HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

    B. P. Wordsworth;J. S. S. Lanchbury;L. I. Sakkas;K. I. Welsh

  • Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer

    Bryan T.J. Hennessy;Kirsten M. Timms;Mark S. Carey;Alexander Gutin

  • A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide.

    S M Wellicome;M H Thornhill;C Pitzalis;D S Thomas

  • PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

    Francisco J. Esteva;Hua Guo;Hua Guo;Siyuan Zhang;Cesar Santa-Maria

  • Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus

    Chi Chiu Mok;Jerry S. Lanchbury;David Wai Chan;Chak Sing Lau

  • Meta‐analysis of genome searches

    L. H. Wise;J. S. Lanchbury;C. M. Lewis

  • Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain

    T D Spector;R W Keen;N K Arden;N A Morrison

  • HLA heterozygosity contributes to susceptibility to rheumatoid arthritis.

    P. Wordsworth;K. D. Pile;J. D. Buckely;J. S. S. Lanchbury

  • Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene

    Francesca Capon;Marie José Bijlmakers;Natalie Wolf;Maria Quaranta

Frequent Co-Authors

Gabriel S. Panayi
Gabriel S. Panayi King's College London
Tim D. Spector
Tim D. Spector King's College London
Robert Vaughan
Robert Vaughan Guy's Hospital
Cathryn M. Lewis
Cathryn M. Lewis King's College London
Ronald E. Bontrop
Ronald E. Bontrop Utrecht University
Costantino Pitzalis
Costantino Pitzalis Queen Mary University of London
Jack Cuzick
Jack Cuzick Queen Mary University of London
William E R Ollier
William E R Ollier University of Manchester
Jane Worthington
Jane Worthington University of Manchester
Leah Gerber
Leah Gerber Duke University

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