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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
13754
World Ranking
16974
National Ranking
6998

Overview

Heiko Runz is affiliated with Biogen in the United States and conducts research primarily in the fields of Biochemistry, Genetics, and Molecular Biology, with significant work also categorized under Medicine. Their research subfields include Genetics, Molecular Biology, Physiology, Neurology, and Psychiatry and Mental Health.

The scientist's work covers a range of topics related to genetic associations and epidemiology, genomics and rare diseases, bioinformatics and genomic networks, as well as specific areas such as BRCA gene mutations in cancer, epigenetics and DNA methylation, RNA research and splicing, and Alzheimer's disease research and treatments.

Recent papers authored or co-authored by Heiko Runz include:

  • Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases (2020, Nature Genetics)
  • Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank (2021, Nature Genetics)
  • Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes (2022, Cell Genomics)
  • Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases (2023, Nature Genetics)
  • The role of polygenic risk and susceptibility genes in breast cancer over the course of life (2020, Nature Communications)

Heiko Runz frequently collaborates with a group of co-authors, which includes Chia-Yen Chen, Aarno Palotie, Ellen Tsai, Sally John, and Mark J. Daly.

The majority of their publications are found in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nature Genetics, Nature, and Zenodo (CERN European Organization for Nuclear Research).

Best Publications

  • Genomic atlas of the human plasma proteome.

    Benjamin Sun;Joseph C Maranville;James E Peters;James E Peters;David Stacey

  • Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

    K. Fassbender;M. Simons;C. Bergmann;M. Stroick

  • New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

    Shrine N;Guyatt Al;Erzurumluoglu Am;Jackson Ve;Jackson Ve;Jackson Ve

  • Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.

    Jie Zheng;Valeriia Haberland;Denis A Baird;Venexia M Walker

  • Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

    Timothy Miller;Merit Cudkowicz;Pamela J. Shaw;Peter M. Andersen

  • Genome-Wide Association Analysis in Primary Sclerosing Cholangitis

    Tom H. Karlsen;Andre Franke;Espen Melum;Arthur Kaser

  • Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

    Chen Yao;George Chen;Ci Song;Joshua Keefe

  • Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease

    Katrin Strauss;Cornelia Goebel;Heiko Runz;Wiebke Möbius

  • Inhibition of Intracellular Cholesterol Transport Alters Presenilin Localization and Amyloid Precursor Protein Processing in Neuronal Cells

    Heiko Runz;Jens Rietdorf;Inge Tomic;Marina de Bernard

  • Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

    Espen Melum;Andre Franke;Christoph Schramm;Tobias J Weismüller

  • Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci

    Trine Folseraas;Trine Folseraas;Espen Melum;Espen Melum;Philipp Rausch;Brian D. Juran

  • Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening

    Fabian Bartz;Fabian Bartz;Luise Kern;Luise Kern;Dorothee Erz;Mingang Zhu;Mingang Zhu

  • Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.

    David Ellinghaus;Trine Folseraas;Kristian Holm;Eva Ellinghaus

  • Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

    Alexander Teumer;Yong Li;Sahar Ghasemi;Bram P Prins

  • Phenome-wide association studies across large population cohorts support drug target validation.

    Dorothée Diogo;Chao Tian;Christopher S. Franklin;Mervi Alanne-Kinnunen

  • Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

    Tobias Schwerd;Sumeet Pandey;Huei-Ting Yang;Katrin Bagola

  • Genetic architecture of human plasma lipidome and its link to cardiovascular disease

    Rubina Tabassum;Joel T Rämö;Pietari Ripatti;Jukka T Koskela

  • Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

    Jie Zheng;Valeriia Haberland;Denis Baird;Venexia Walker

  • Advancing Human Genetics Research and Drug Discovery through Exome Sequencing of the UK Biobank

    Joseph D. Szustakowski;Suganthi Balasubramanian;Ariella Sasson;Shareef Khalid

  • Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

    Wouter van Rheenen;Rick A. A. van der Spek;Mark K. Bakker;Joke J. F. A. van Vugt

Frequent Co-Authors

Chia-Yen Chen
Chia-Yen Chen Harvard University
John Danesh
John Danesh University of Cambridge
Rainer Pepperkok
Rainer Pepperkok European Molecular Biology Laboratory
Mark J. Daly
Mark J. Daly Massachusetts General Hospital
Samuli Ripatti
Samuli Ripatti University of Helsinki
Adam S. Butterworth
Adam S. Butterworth University of Cambridge
Aarno Palotie
Aarno Palotie University of Helsinki
Tom H. Karlsen
Tom H. Karlsen Oslo University Hospital
Terho Lehtimäki
Terho Lehtimäki Tampere University
Olli T. Raitakari
Olli T. Raitakari Turku University Hospital

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