World's Best Scientists 2026 revealed!

Overview

Frank Rösch is affiliated with Johannes Gutenberg University of Mainz in Germany and has contributed extensively to the field of medicine, focusing primarily on radiology, nuclear medicine and imaging, oncology, surgery, pulmonary and respiratory medicine, and cellular and molecular neuroscience.

Their research spans multiple subfields with significant work in radiopharmaceutical chemistry and applications, peptidase inhibition and analysis, cardiac structural anomalies and repair, medical imaging techniques and applications, neuropeptides and animal physiology, neuroendocrine tumor research advances, and prostate cancer treatment and research.

Key recent publications by Frank Rösch include:

  • Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators, 2020, EJNMMI Radiopharmacy and Chemistry
  • On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion, 2020, Nuclear Medicine and Biology
  • New Frontiers in Cancer Imaging and Therapy Based on Radiolabeled Fibroblast Activation Protein Inhibitors: A Rational Review and Current Progress, 2021, Pharmaceuticals
  • First-in-Human Experience With 177Lu-DOTAGA.(SA.FAPi)2 Therapy in an Uncommon Case of Aggressive Medullary Thyroid Carcinoma Clinically Mimicking as Anaplastic Thyroid Cancer, 2022, Clinical Nuclear Medicine
  • Image quality analysis of 44Sc on two preclinical PET scanners: a comparison to 68Ga, 2020, EJNMMI Physics

Frequent coauthors associated with their work include:

  • Euy Sung Moon
  • Lukas Greifenstein
  • Axel Rominger
  • Eleni Gourni
  • Tilmann Grus

Publications tend to appear repeatedly in several scientific journals, notably:

  • Nuklearmedizin - NuclearMedicine (11 publications)
  • European Journal of Nuclear Medicine and Molecular Imaging (4 publications)
  • EJNMMI Radiopharmacy and Chemistry (3 publications)
  • Nuclear Medicine and Biology (3 publications)
  • Pharmaceuticals (3 publications)

Their work interfaces with clinical applications, especially those involving advanced diagnostic and therapeutic methods based on radiolabeled compounds targeted to specific proteins such as fibroblast activation protein. This includes innovations in positron emission tomography (PET) imaging agents and therapies affecting cancer types and other medical conditions related to cardiac and molecular neuroscience fields.

Best Publications

  • Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving.

    Andreas Heinz;Thomas Siessmeier;Jana Wrase;Derik Hermann

  • Processing of Generator-Produced 68Ga for Medical Application

    Konstantin P. Zhernosekov;Dimitry V. Filosofov;Richard P. Baum;Peter Aschoff

  • Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients.

    Andreas Heinz;Thomas Siessmeier;Jana Wrase;Hans Georg Buchholz

  • Association of Low Striatal Dopamine D2 Receptor Availability With Nicotine Dependence Similar to That Seen With Other Drugs of Abuse

    Christoph Fehr;Igor Yakushev;Nina Hohmann;Hans-Georg Buchholz

  • The Impact of Radioactivity on Medicine Metallic

    G. Stöcklin;S. M. Qaim;F. Rösch

  • High opiate receptor binding potential in the human lateral pain system.

    Ulf Baumgärtner;Hans-Georg Buchholz;Alexander Bellosevich;Walter Magerl

  • Preliminary data on biodistribution and dosimetry for therapy planning of somatostatin receptor positive tumours: comparison of (86)Y-DOTATOC and (111)In-DTPA-octreotide.

    Gregor J. Förster;Martin Engelbach;Jörg Brockmann;Helmut Reber

  • A Triazacyclononane‐Based Bifunctional Phosphinate Ligand for the Preparation of Multimeric 68Ga Tracers for Positron Emission Tomography

    Johannes Notni;Johannes Notni;Petr Hermann;Jana Havlíčková;Jan Kotek

  • Generator-based PET radiopharmaceuticals for molecular imaging of tumours: on the way to THERANOSTICS

    Frank Rösch;Richard P. Baum

  • Measurement of Pharmacokinetics of Yttrium-86 Radiopharmaceuticals with PET and Radiation Dose Calculation of Analogous Yttrium-90 Radiotherapeutics

    Hans Herzog;Frank Rösch;Gerhard Stöcklin;Christoph Lueders

  • Positron emission tomography in CNS drug discovery and drug monitoring.

    Markus Piel;Ingo Vernaleken;Frank Rösch

  • Nuclear Data Relevant to the Production of the Positron Emitting Radioisotope 86Y via the 86Sr(p,n)- and natRb(3He,xn)-Processes

    F. Rösch;S. M. Qaim;G. Stöcklin

  • A 44Ti/44Sc radionuclide generator for potential application of 44Sc-based PET-radiopharmaceuticals

    D. V. Filosofov;N. S. Loktionova;Frank Rösch

  • Uptake kinetics of the somatostatin receptor ligand [86Y]DOTA-DPhe1- Tyr3-octreotide ([86Y]SMT487) using positron emission tomography in non-human primates and calculation of radiation doses of the 90Y-labelled analogue.

    Frank Rösch;Hans Herzog;Barbara Stolz;Jörg Brockmann

  • PET/CT imaging of osteoblastic bone metastases with (68)Ga-bisphosphonates: first human study.

    Marco Fellner;Richard P. Baum;Vojtěch Kubíček;Petr Hermann

  • PET-pharmacokinetics of 18F-octreotide: A comparison with 67Ga-DFO and 86Y-DTPA-octreotide

    Hans-Jürgen Wester;Jörg Brockmann;Frank Rösch;Walter Wutz

  • Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography.

    Matthias M Herth;Matthias Barz;Dorothea Moderegger;Mareli Allmeroth

  • The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia.

    Gerhard Gründer;Gerhard Gründer;Christian Landvogt;Ingo Vernaleken;Ingo Vernaleken;Hans Georg Buchholz

  • Production of the Positron Emitting Radioisotope 86Y for Nuclear Medical Application

    F. Rösch;S.M. Qaim;G. Stöcklin

  • Electron- and Positron-Emitting Radiolanthanides for Therapy: Aspects of Dosimetry and Production

    Helena Uusijärvi;Peter Bernhardt;Frank Rösch;Helmut R Maecke

Frequent Co-Authors

Rudolf Zentel
Rudolf Zentel Johannes Gutenberg University of Mainz
Petr Hermann
Petr Hermann Charles University
Paul Cumming
Paul Cumming Queensland University of Technology
Peter Stoeter
Peter Stoeter Johannes Gutenberg University of Mainz
Kaloian Koynov
Kaloian Koynov Max Planck Institute for Polymer Research
Michael Bachmann
Michael Bachmann Helmholtz-Zentrum Dresden-Rossendorf
Bernd Kaina
Bernd Kaina Johannes Gutenberg University of Mainz
Jana Wrase
Jana Wrase Charité - University Medicine Berlin
Matthias Barz
Matthias Barz Johannes Gutenberg University of Mainz

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