World's Best Scientists 2026 revealed!

D-Index & Metrics

Mathematics

D-Index
55
Citations
27880
World Ranking
763
National Ranking
14

Frank Bretz publication distribution in Mathematics in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Mathematics in 2026. The highlighted bar marks where Frank Bretz sits on this spectrum.

42–46 publications: 3 scientists 47–51 publications: 5 scientists 52–56 publications: 7 scientists 57–61 publications: 20 scientists 62–66 publications: 14 scientists 67–71 publications: 25 scientists 72–76 publications: 19 scientists 77–81 publications: 35 scientists 82–86 publications: 50 scientists 87–91 publications: 60 scientists 92–96 publications: 86 scientists 97–101 publications: 84 scientists 102–106 publications: 83 scientists 107–111 publications: 90 scientists 112–116 publications: 99 scientists 117–121 publications: 90 scientists 122–126 publications: 91 scientists 127–131 publications: 109 scientists 132–136 publications: 110 scientists 137–141 publications: 98 scientists 142–146 publications: 112 scientists 147–151 publications: 102 scientists 152–156 publications: 88 scientists 157–161 publications: 106 scientists 162–166 publications: 83 scientists 167–171 publications: 102 scientists 172–176 publications: 77 scientists 177–181 publications: 81 scientists 182–186 publications: 78 scientists 187–191 publications: 71 scientists 192–196 publications: 92 scientists 197–201 publications: 64 scientists 202–206 publications: 69 scientists 207–211 publications: 64 scientists 212–216 publications: 62 scientists 217–221 publications: 58 scientists 222–226 publications: 53 scientists 227–231 publications: 50 scientists 232–236 publications: 46 scientists 237–241 publications: 46 scientists 242–246 publications: 46 scientists 247–251 publications: 43 scientists 252–256 publications: 29 scientists 257–261 publications: 45 scientists 262–266 publications: 30 scientists 267–271 publications: 33 scientists 272–276 publications: 34 scientists 277–281 publications: 30 scientists 282–286 publications: 31 scientists 287–291 publications: 21 scientists 292–296 publications: 34 scientists 297–301 publications: 26 scientists 302–306 publications: 10 scientists 307–311 publications: 17 scientists 312–316 publications: 23 scientists 317–321 publications: 13 scientists 322–326 publications: 16 scientists 327–331 publications: 26 scientists 332–336 publications: 13 scientists 337–341 publications: 13 scientists 342–346 publications: 16 scientists 347–351 publications: 17 scientists 352–356 publications: 12 scientists 357–361 publications: 18 scientists 362–366 publications: 18 scientists 367–371 publications: 9 scientists 372–376 publications: 11 scientists 377–381 publications: 8 scientists 382–386 publications: 8 scientists 387–391 publications: 9 scientists 392–396 publications: 9 scientists 397–401 publications: 8 scientists 402–406 publications: 11 scientists 407–411 publications: 6 scientists 412–416 publications: 6 scientists 417–421 publications: 9 scientists 422–426 publications: 8 scientists 427–431 publications: 5 scientists 432–436 publications: 8 scientists 437–441 publications: 8 scientists 442–446 publications: 4 scientists 447–451 publications: 4 scientists 452–456 publications: 4 scientists 457–461 publications: 2 scientists 462–466 publications: 2 scientists 467–471 publications: 4 scientists 472–476 publications: 3 scientists 477–481 publications: 3 scientists 482–486 publications: 6 scientists 487–491 publications: 3 scientists 492–496 publications: 5 scientists 497–501 publications: 5 scientists 502–506 publications: 1 scientists 507–511 publications: 6 scientists 512–516 publications: 4 scientists 517–521 publications: 1 scientists 522–526 publications: 3 scientists 527–531 publications: 1 scientists 532–536 publications: 4 scientists 537+ publications: 100 scientists
42 publications 537+

This scientist: 237 publications — 74th percentile

74% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 537 publications or more.

Frank Bretz D-index placement in Mathematics in 2026

The chart shows the D-index (discipline H-index) distribution of Mathematics scientists ranked by Research.com in 2026. The highlighted bar marks where Frank Bretz sits on this spectrum.

30 D-Index: 174 scientists 31 D-Index: 151 scientists 32 D-Index: 174 scientists 33 D-Index: 117 scientists 34 D-Index: 136 scientists 35 D-Index: 127 scientists 36 D-Index: 145 scientists 37 D-Index: 153 scientists 38 D-Index: 150 scientists 39 D-Index: 150 scientists 40 D-Index: 138 scientists 41 D-Index: 136 scientists 42 D-Index: 93 scientists 43 D-Index: 108 scientists 44 D-Index: 115 scientists 45 D-Index: 112 scientists 46 D-Index: 103 scientists 47 D-Index: 75 scientists 48 D-Index: 59 scientists 49 D-Index: 67 scientists 50 D-Index: 60 scientists 51 D-Index: 57 scientists 52 D-Index: 59 scientists 53 D-Index: 62 scientists 54 D-Index: 60 scientists 55 D-Index: 50 scientists 56 D-Index: 42 scientists 57 D-Index: 54 scientists 58 D-Index: 50 scientists 59 D-Index: 42 scientists 60 D-Index: 41 scientists 61 D-Index: 35 scientists 62 D-Index: 40 scientists 63 D-Index: 21 scientists 64 D-Index: 31 scientists 65 D-Index: 27 scientists 66 D-Index: 29 scientists 67 D-Index: 19 scientists 68 D-Index: 25 scientists 69 D-Index: 17 scientists 70 D-Index: 18 scientists 71 D-Index: 12 scientists 72 D-Index: 14 scientists 73 D-Index: 13 scientists 74 D-Index: 18 scientists 75 D-Index: 9 scientists 76 D-Index: 11 scientists 77 D-Index: 10 scientists 78 D-Index: 9 scientists 79 D-Index: 16 scientists 80 D-Index: 12 scientists 81 D-Index: 10 scientists 82 D-Index: 5 scientists 83 D-Index: 5 scientists 84 D-Index: 13 scientists 85 D-Index: 6 scientists 86+ D-Index: 99 scientists
30 D-Index 86+

This scientist: 55 D-Index — 79th percentile

79% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 86 D-Index or more.

Research.com Recognitions

  • 2015 - Fellow of the American Statistical Association (ASA)

Overview

Frank Bretz is affiliated with Novartis in Switzerland and has a significant body of research primarily focused on statistical methods applied to clinical trials and related areas. The main field of study encompasses Mathematics, with a specific emphasis on Statistics and Probability. Bretz's work spans related subfields such as Economics and Econometrics, Management Science and Operations Research, and Oncology.

The scientist's research covers core topics including statistical methods in clinical trials, statistical inference techniques, health systems and economic evaluations, causal inference techniques, optimal experimental design, and Bayesian inference models. These areas reflect a comprehensive engagement with both theoretical statistics and practical applications in biopharmaceutical and clinical research contexts.

Recent publications include:

  • "Machine learning for clinical trials in the era of COVID-19" (2020), published in Statistics in Biopharmaceutical Research
  • "Challenges in Assessing the Impact of the COVID-19 Pandemic on the Integrity and Interpretability of Clinical Trials" (2020), published in Statistics in Biopharmaceutical Research
  • "Some uses of predictive probability of success in clinical drug development" (2022), published in Epidemiology Biostatistics and Public Health
  • "Reference range: Which statistical intervals to use?" (2020), published in Statistical Methods in Medical Research
  • "Commentary on Parker and Weir" (2020), published in Clinical Trials

Frequent coauthors collaborating with Frank Bretz include:

  • Wei Liu
  • Kelly Van Lancker
  • Martin Posch
  • Emmanuel Zuber
  • Sergey Tarima

The most common publication venues are:

  • Statistics in Biopharmaceutical Research
  • Statistics in Medicine
  • arXiv (Cornell University)
  • Biometrical Journal
  • Clinical Trials

Frank Bretz's work is recognized within the statistical community by election as a Fellow of the American Statistical Association (ASA) in 2015. This distinction acknowledges contributions to the advancement of statistical science.

Best Publications

  • Simultaneous inference in general parametric models.

    Torsten Hothorn;Frank Bretz;Peter Westfall

  • Multiple Comparisons Using R

    Frank Bretz;Torsten Hothorn;Peter H. Westfall

  • Computation of Multivariate Normal and t Probabilities

    Alan Genz;Frank Bretz

  • Multivariate Normal and t Distributions

    Alan Genz;Frank Bretz;Tetsuhisa Miwa;Xuefei Mi

  • A graphical approach to sequentially rejective multiple test procedures

    Frank Bretz;Willi Maurer;Werner Brannath;Martin Posch

  • Combining multiple comparisons and modeling techniques in dose-response studies.

    F. Bretz;J. C. Pinheiro;M. Branson

  • Package multcomp: Simultaneous Inference in General Parametric Models

    T Hothorn;F Bretz;Peter Westfall

  • Comparison of Methods for the Computation of Multivariate t Probabilities

    Alan Genz;Frank Bretz

  • Multiple Testing Problems in Pharmaceutical Statistics

    Alex Dmitrienko;Ajit C. Tamhane;Frank Bretz;Frank Bretz

  • Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: General Concepts

    Frank Bretz;Heinz Schmidli;Franz König;Amy Racine

  • Adaptive designs for confirmatory clinical trials.

    Frank Bretz;Franz Koenig;Werner Brannath;Ekkehard Glimm

  • Model‐based dose finding under model uncertainty using general parametric models

    José Pinheiro;Björn Bornkamp;Ekkehard Glimm;Frank Bretz

  • Twenty-five years of confirmatory adaptive designs: opportunities and pitfalls

    Peter Bauer;Frank Bretz;Frank Bretz;Vladimir Dragalin;Franz König

  • Confirmatory adaptive designs with Bayesian decision tools for a targeted therapy in oncology.

    Werner Brannath;Emmanuel Zuber;Michael Branson;Frank Bretz;Frank Bretz

  • Innovative approaches for designing and analyzing adaptive dose-ranging trials.

    Björn Bornkamp;Frank Bretz;Alex Dmitrienko;Greg Enas

  • Numerical computation of multivariate t-probabilities with application to power calculation of multiple contrasts

    Alan Genz;Frank Bretz

  • Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests

    Frank Bretz;Martin Posch;Ekkehard Glimm;Florian Klinglmueller

  • Optimal Designs for Dose-Finding Studies

    Holger Dette;Frank Bretz;Andrey Pepelyshev;José Pinheiro

  • Compatible simultaneous lower confidence bounds for the Holm procedure and other Bonferroni-based closed tests.

    Klaus Strassburger;Frank Bretz

  • Assessment of optimal selected prognostic factors

    Berthold Lausen;Torsten Hothorn;Frank Bretz;Martin Schumacher

Frequent Co-Authors

Holger Dette
Holger Dette Ruhr University Bochum
Peter H. Westfall
Peter H. Westfall Texas Tech University
Nigel Stallard
Nigel Stallard University of Warwick
Ajit C. Tamhane
Ajit C. Tamhane Northwestern University
Gary G. Koch
Gary G. Koch University of North Carolina at Chapel Hill
Thomas J. Vogl
Thomas J. Vogl Goethe University Frankfurt
Stefan Schreiber
Stefan Schreiber Kiel University
Hubert G. M. Leufkens
Hubert G. M. Leufkens Utrecht University
Jeffrey R. Brown
Jeffrey R. Brown University of Illinois at Urbana-Champaign
Hans Lehrach
Hans Lehrach Max Planck Society

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