Einar M. Sigurdsson

Best Publications

• Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

  C Soto;E M Sigurdsson;L Morelli;R A Kumar

  1148
  Citations

• Tau-targeting therapies for Alzheimer disease.

  Erin E. Congdon;Einar M. Sigurdsson

  1058
  Citations

• Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements

  Ayodeji A. Asuni;Allal Boutajangout;David Quartermain;Einar M. Sigurdsson

  601
  Citations

• Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging

  J. F. Poduslo;T. M. Wengenack;G. L. Curran;T. Wisniewski

  535
  Citations

• Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain.

  Allal Boutajangout;Johanna Ingadottir;Peter Davies;Einar M. Sigurdsson

  370
  Citations

• Immunization with a Nontoxic/Nonfibrillar Amyloid-β Homologous Peptide Reduces Alzheimer's Disease-Associated Pathology in Transgenic Mice

  Einar M. Sigurdsson;Henrieta Scholtzova;Pankaj D. Mehta;Blas Frangione

  353
  Citations

• Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

  Youssef Zaim Wadghiri;Einar M. Sigurdsson;Marcin Sadowski;James I. Elliott

  352
  Citations

• Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.

  Allal Boutajangout;David Quartermain;Einar M. Sigurdsson

  322
  Citations

• Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.

  M. Fá;D. Puzzo;D. Puzzo;R. Piacentini;Agnieszka Staniszewski

  292
  Citations

• Tau immunotherapy for Alzheimer's disease.

  Jan Torleif Pedersen;Einar M. Sigurdsson

  282
  Citations

• Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.

  Joseph F. Poduslo;Thomas M. Wengenack;Geoffry L. Curran;Thomas Wisniewski

  282
  Citations

• Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease

  Charles Y. Shao;Suzanne S. Mirra;Hameetha B. R. Sait;Todd C. Sacktor

  248
  Citations

• Copper chelation delays the onset of prion disease.

  Einar M. Sigurdsson;David R. Brown;Muhammad A. Alim;Henrieta Scholtzova

  244
  Citations

• Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance

  Erin E. Congdon;Jiaping Gu;Hameetha B.R. Sait;Einar M. Sigurdsson

  222
  Citations

• Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology

  Jiaping Gu;Erin E. Congdon;Einar M. Sigurdsson

  197
  Citations

• An Attenuated Immune Response Is Sufficient to Enhance Cognition in an Alzheimer's Disease Mouse Model Immunized with Amyloid- Derivatives

  Einar M. Sigurdsson;Elin Knudsen;Ayodeji Asuni;Cheryl Fitzer-Attas

  191
  Citations

• A synthetic peptide blocking the apolipoprotein E/β-amyloid binding mitigates β-amyloid toxicity and fibril formation in vitro and reduces β-amyloid plaques in transgenic mice

  Marcin Sadowski;Joanna Pankiewicz;Henrieta Scholtzova;James A. Ripellino

  187
  Citations

• Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

  Einar M. Sigurdsson

  170
  Citations

• Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging.

  Henrieta Scholtzova;Youssef Z. Wadghiri;Moustafa Douadi;Einar M. Sigurdsson

  158
  Citations

• In vivo reversal of amyloid-β lesions in rat brain

  Einar M. Sigurdsson;Bruno Permanne;Claudio Soto;Thomas Wisniewski

  158
  Citations