His primary areas of investigation include Nitric oxide, Biochemistry, Internal medicine, Endocrinology and Endothelium. His Nitric oxide research incorporates themes from Glutathione and Cell biology. His work in the fields of Biochemistry, such as Endothelial stem cell, Arginine, Membrane transport and ATP synthase, overlaps with other areas such as S-Nitrosylation.
His work carried out in the field of Endothelial stem cell brings together such families of science as Hypoxia, Arginase, Downregulation and upregulation, Pulmonary hypertension and Pulmonary artery. His studies deal with areas such as Surgery and Cardiology as well as Internal medicine. His Endothelium research is multidisciplinary, incorporating perspectives in Extracellular, Membrane fluidity and Lactate dehydrogenase.
His main research concerns Endothelial stem cell, Biochemistry, Molecular biology, Nitric oxide and Endothelium. His biological study spans a wide range of topics, including Blood vessel, Endocrinology, Hypoxia, Internal medicine and Pulmonary artery. His work in Biochemistry addresses subjects such as Hyperoxia, which are connected to disciplines such as Cell membrane, Cell and Lactate dehydrogenase.
His Molecular biology study also includes fields such as
His main research concerns Cell biology, Nitric oxide, Lung, Arginase and Biochemistry. His Cell biology research includes elements of Apoptosis, Internalization and Nitric oxide synthase, Enos. Edward R. Block is exploring Nitric oxide as part of his Endocrinology and Internal medicine and Nitric oxide studies.
The study incorporates disciplines such as Fructose and Hypertension obesity in addition to Internal medicine. Many of his studies on Arginase apply to Endothelial stem cell as well. His research brings together the fields of Endothelium and Biochemistry.
Edward R. Block mainly focuses on Nitric oxide, Internal medicine, Endocrinology, Endothelium and Hypoxia. Edward R. Block has researched Nitric oxide in several fields, including Molecular biology, Peptide sequence and Alanine. The various areas that Edward R. Block examines in his Internal medicine study include Endothelial stem cell and Arginase.
Edward R. Block works mostly in the field of Arginase, limiting it down to topics relating to Cancer research and, in certain cases, Lung. His Endothelium research is multidisciplinary, relying on both Apoptosis, Biochemistry, Programmed cell death, Gelatinase and Metalloproteinase. His Pulmonary hypertension study combines topics in areas such as Endothelial dysfunction, Metabolic syndrome, Ischemia, Vasoconstriction and Hyperuricemia.
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Hyperuricemia induces endothelial dysfunction.
Uday M. Khosla;Sergey Zharikov;Jennifer L. Finch;Takahiko Nakagawa.
Kidney International (2005)
A causal role for uric acid in fructose-induced metabolic syndrome
Takahiko Nakagawa;Hanbo Hu;Sergey Zharikov;Katherine R Tuttle.
American Journal of Physiology-renal Physiology (2006)
A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric-oxide Synthase May Explain the “Arginine Paradox”
Kelly K. McDonald;Sergei Zharikov;Edward R. Block;Michael S. Kilberg.
Journal of Biological Chemistry (1997)
Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells
Yunchao Su;Weihong Han;Carlos Giraldo;Yong De Li.
American Journal of Respiratory Cell and Molecular Biology (1998)
Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells
Sergey Zharikov;Karina Krotova;Hanbo Hu;Chris Baylis.
American Journal of Physiology-cell Physiology (2008)
Regulation of endothelial nitric oxide synthase by the actin cytoskeleton.
Yunchao Su;Sophia Edwards-Bennett;Michael R. Bubb;Michael R. Bubb;Edward R. Block;Edward R. Block.
American Journal of Physiology-cell Physiology (2003)
Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells.
Jianliang Zhang;Bilian Jin;Liuzhe Li;Edward R. Block.
American Journal of Physiology-cell Physiology (2005)
Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity.
J M Patel;J Zhang;E R Block.
American Journal of Respiratory Cell and Molecular Biology (1996)
Characterization of L-glutamine transport by pulmonary artery endothelial cells.
K. Herskowitz;B. P. Bode;E. R. Block;W. W. Souba.
American Journal of Physiology-lung Cellular and Molecular Physiology (1991)
Mechanism of hypoxic injury to pulmonary artery endothelial cell plasma membranes.
E. R. Block;J. M. Patel;D. Edwards.
American Journal of Physiology-cell Physiology (1989)
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