D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 51 Citations 8,951 128 World Ranking 12644 National Ranking 5383

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Amino acid

His primary areas of investigation include Nitric oxide, Biochemistry, Internal medicine, Endocrinology and Endothelium. His Nitric oxide research incorporates themes from Glutathione and Cell biology. His work in the fields of Biochemistry, such as Endothelial stem cell, Arginine, Membrane transport and ATP synthase, overlaps with other areas such as S-Nitrosylation.

His work carried out in the field of Endothelial stem cell brings together such families of science as Hypoxia, Arginase, Downregulation and upregulation, Pulmonary hypertension and Pulmonary artery. His studies deal with areas such as Surgery and Cardiology as well as Internal medicine. His Endothelium research is multidisciplinary, incorporating perspectives in Extracellular, Membrane fluidity and Lactate dehydrogenase.

His most cited work include:

  • A causal role for uric acid in fructose-induced metabolic syndrome (831 citations)
  • Hyperuricemia induces endothelial dysfunction. (826 citations)
  • A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric-oxide Synthase May Explain the “Arginine Paradox” (422 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Endothelial stem cell, Biochemistry, Molecular biology, Nitric oxide and Endothelium. His biological study spans a wide range of topics, including Blood vessel, Endocrinology, Hypoxia, Internal medicine and Pulmonary artery. His work in Biochemistry addresses subjects such as Hyperoxia, which are connected to disciplines such as Cell membrane, Cell and Lactate dehydrogenase.

His Molecular biology study also includes fields such as

  • Calpain which is related to area like Angiogenesis,
  • Lung injury and Citrulline most often made with reference to Intracellular. As part of one scientific family, Edward R. Block deals mainly with the area of Nitric oxide, narrowing it down to issues related to the Cell biology, and often Actin cytoskeleton. His Endothelium study incorporates themes from Apoptosis, In vitro and Immunology.

He most often published in these fields:

  • Endothelial stem cell (64.41%)
  • Biochemistry (59.89%)
  • Molecular biology (38.98%)

What were the highlights of his more recent work (between 2006-2015)?

  • Cell biology (32.77%)
  • Nitric oxide (38.42%)
  • Lung (24.86%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cell biology, Nitric oxide, Lung, Arginase and Biochemistry. His Cell biology research includes elements of Apoptosis, Internalization and Nitric oxide synthase, Enos. Edward R. Block is exploring Nitric oxide as part of his Endocrinology and Internal medicine and Nitric oxide studies.

The study incorporates disciplines such as Fructose and Hypertension obesity in addition to Internal medicine. Many of his studies on Arginase apply to Endothelial stem cell as well. His research brings together the fields of Endothelium and Biochemistry.

Between 2006 and 2015, his most popular works were:

  • Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. (167 citations)
  • Hypoxic upregulation of arginase II in human lung endothelial cells (57 citations)
  • Hypoxic upregulation of arginase II in human lung endothelial cells (57 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

Edward R. Block mainly focuses on Nitric oxide, Internal medicine, Endocrinology, Endothelium and Hypoxia. Edward R. Block has researched Nitric oxide in several fields, including Molecular biology, Peptide sequence and Alanine. The various areas that Edward R. Block examines in his Internal medicine study include Endothelial stem cell and Arginase.

Edward R. Block works mostly in the field of Arginase, limiting it down to topics relating to Cancer research and, in certain cases, Lung. His Endothelium research is multidisciplinary, relying on both Apoptosis, Biochemistry, Programmed cell death, Gelatinase and Metalloproteinase. His Pulmonary hypertension study combines topics in areas such as Endothelial dysfunction, Metabolic syndrome, Ischemia, Vasoconstriction and Hyperuricemia.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Hyperuricemia induces endothelial dysfunction.

Uday M. Khosla;Sergey Zharikov;Jennifer L. Finch;Takahiko Nakagawa.
Kidney International (2005)

1462 Citations

A causal role for uric acid in fructose-induced metabolic syndrome

Takahiko Nakagawa;Hanbo Hu;Sergey Zharikov;Katherine R Tuttle.
American Journal of Physiology-renal Physiology (2006)

1423 Citations

A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric-oxide Synthase May Explain the “Arginine Paradox”

Kelly K. McDonald;Sergei Zharikov;Edward R. Block;Michael S. Kilberg.
Journal of Biological Chemistry (1997)

647 Citations

Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells

Yunchao Su;Weihong Han;Carlos Giraldo;Yong De Li.
American Journal of Respiratory Cell and Molecular Biology (1998)

438 Citations

Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells

Sergey Zharikov;Karina Krotova;Hanbo Hu;Chris Baylis.
American Journal of Physiology-cell Physiology (2008)

272 Citations

Regulation of endothelial nitric oxide synthase by the actin cytoskeleton.

Yunchao Su;Sophia Edwards-Bennett;Michael R. Bubb;Michael R. Bubb;Edward R. Block;Edward R. Block.
American Journal of Physiology-cell Physiology (2003)

152 Citations

Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells.

Jianliang Zhang;Bilian Jin;Liuzhe Li;Edward R. Block.
American Journal of Physiology-cell Physiology (2005)

126 Citations

Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity.

J M Patel;J Zhang;E R Block.
American Journal of Respiratory Cell and Molecular Biology (1996)

121 Citations

Characterization of L-glutamine transport by pulmonary artery endothelial cells.

K. Herskowitz;B. P. Bode;E. R. Block;W. W. Souba.
American Journal of Physiology-lung Cellular and Molecular Physiology (1991)

114 Citations

Mechanism of hypoxic injury to pulmonary artery endothelial cell plasma membranes.

E. R. Block;J. M. Patel;D. Edwards.
American Journal of Physiology-cell Physiology (1989)

113 Citations

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