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D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
12705
World Ranking
7984
National Ranking
3613

Overview

Dean J. Tuma is affiliated with the University of Nebraska Medical Center in the United States. Their research spans multiple fields within medical sciences, including immunology, molecular biology, epidemiology, endocrinology, diabetes, metabolism, and hepatology. The scientist's body of work focuses predominantly on the interactions between immune responses and liver diseases, as well as metabolic factors influencing disease progression.

Their scholarly contributions include research on immunotherapy and immune responses, RNA interference and gene delivery, liver disease diagnosis and treatment, diet, metabolism, and disease, and the interplay between liver diseases and immunity.

Dean J. Tuma has published scientific papers in the venue UNC Libraries, contributing at least two works with research topics related to liver disease and immunological mechanisms. The recent papers include:

  • Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde, 2020, UNC Libraries
  • Autoimmune Hepatitis Induced by Syngeneic Liver Cytosolic Proteins Biotransformed by Alcohol Metabolites, 2020, UNC Libraries

The scientist frequently collaborated with a number of coauthors across their research. These collaborators include Michael J. Duryee, Lynell W. Klassen, Monte S. Willis, Geoffrey M. Thiele, and Bonnie L. Jones, indicating a pattern of ongoing research partnerships within their fields of study.

Dean J. Tuma's research addresses complex biological and immunological processes that underpin liver diseases, including autoimmune hepatitis and the body's immune response to chemically modified liver cells. This work is situated within the broader study domains of medicine and hepatology, emphasizing integrative approaches to understanding disease mechanisms and treatment avenues.

Best Publications

  • Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration

    Dean J. Tuma;Geoffrey Milton Thiele;Dongsheng Xu;Lynell Warren Klassen

  • Acetaldehyde adducts with proteins: binding of [14C]acetaldehyde to serum albumin.

    Terrence Donohue;Terrence Donohue;Dean J. Tuma;Michael Floyd Sorrell

  • Role of malondialdehyde-acetaldehyde adducts in liver injury.

    Dean J Tuma

  • Dangerous byproducts of alcohol breakdown--focus on adducts

    Dean J. Tuma;Carol A. Casey

  • Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration.

    Anthony J. Barak;Harriet C. Beckenhauer;Matti Junnila;Dean J. Tuma

  • Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway.

    Kusum Kharbanda;Mark E Mailliard;Mark E Mailliard;Cheryl R. Baldwin;Harriet C. Beckenhauer

  • Detection of circulating antibodies against malondialdehyde‐acetaldehyde adducts in patients with alcohol‐induced liver disease

    Roberta Rolla;Daria Vay;Elisa Mottaran;Monica Parodi

  • Effects of prolonged ethanol feeding on methionine metabolism in rat liver

    Anthony J. Barak;Harriet C. Beckenhauer;Dean J. Tuma;Shahrokh Badakhsh

  • Covalent Binding of Acetaldehyde to Proteins: Participation of Lysine Residues

    Dean J. Tuma;Monte R. Newman;Terrence M. Donohue;Michael F. Sorrell

  • Reaction of acetaldehyde with human erythrocyte membrane proteins

    Katherine C. Gaines;J. M. Salhany;D. J. Tuma;Michael Floyd Sorrell

  • Hypothesis: alcoholic liver injury and the covalent binding of acetaldehyde.

    Michael F. Sorrell;Dean J. Tuma

  • Malondialdehyde-acetaldehyde adducts and anti-malondialdehyde-acetaldehyde antibodies in rheumatoid arthritis.

    Geoffrey Milton Thiele;Michael J. Duryee;Daniel R Anderson;Lynell Warren Klassen

  • Betaine, ethanol, and the liver: a review

    Anthony J. Barak;Harriet C. Beckenhauer;Dean J. Tuma

  • Betaine Lowers Elevated S-Adenosylhomocysteine Levels in Hepatocytes from Ethanol-Fed Rats

    Anthony J. Barak;Anthony J. Barak;Harriet C. Beckenhauer;Mark E. Mailliard;Kusum K. Kharbanda;Kusum K. Kharbanda

  • Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant.

    Geoffrey Milton Thiele;Dean J. Tuma;Dean J. Tuma;Monte S. Willis;Jacqueline A. Miller;Jacqueline A. Miller

  • Covalent binding of acetaldehyde selectively inhibits the catalytic activity of lysine-dependent enzymes.

    Teri J. Mauch;Terrence M. Donohue;Rowen K. Zetterman;Michael F. Sorrell

  • Chronic ethanol administration impairs the binding and endocytosis of asialo-orosomucoid in isolated hepatocytes.

    C A Casey;S L Kragskow;M F Sorrell;D J Tuma

  • Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis

    Michael J. Duryee;Lynell Warren Klassen;Courtney S. Schaffert;Courtney S. Schaffert;Dean J. Tuma

  • Association of malondialdehyde-acetaldehyde (MAA) adducted proteins with atherosclerotic-induced vascular inflammatory injury

    Gary E Hill;Jacqueline A Miller;B.Timothy Baxter;Lynell W Klassen

  • Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: Protection by betaine

    Kusum K. Kharbanda;David D. Rogers;Mark E. Mailliard;Gerri L. Siford

Frequent Co-Authors

Lynell Warren Klassen
Lynell Warren Klassen University of Nebraska Medical Center
Geoffrey M. Thiele
Geoffrey M. Thiele University of Nebraska Medical Center
Stephen I. Rennard
Stephen I. Rennard University of Nebraska Medical Center
Howard S. Fox
Howard S. Fox University of Nebraska Medical Center
Thomas W. Smith
Thomas W. Smith University of California, Davis
Jacob Selhub
Jacob Selhub Tufts University
Tatiana K. Bronich
Tatiana K. Bronich University of Nebraska Medical Center
Hiroshi Suzuki
Hiroshi Suzuki Obihiro University of Agriculture and Veterinary Medicine
Mark A. McNiven
Mark A. McNiven Mayo Clinic
David J. Greenblatt
David J. Greenblatt Tufts University

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