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Chemistry

D-Index
52
Citations
11753
World Ranking
13413
National Ranking
758

Overview

David W. Roberts is affiliated with Liverpool John Moores University in the United Kingdom. Their scholarly work primarily falls within the field of Medicine, with a particular focus on Dermatology. This subfield includes significant research related to skin-related conditions and exposures.

Their publication record shows contributions to specialized areas including Organic Chemistry, Public Health, Environmental and Occupational Health, Small Animals, and Plant Science. These subfields complement the main focus of their research, reflecting a broad interdisciplinary approach.

Roberts's research topics concentrate on areas such as Contact Dermatitis and Allergies, Occupational Exposure and Asthma, Animal Testing and Alternatives, and Pesticide Exposure and Toxicity. Other key subjects include Effects and Risks of Endocrine Disrupting Chemicals, Agricultural Safety and Regulations, and Dermatology and Skin Diseases.

Frequent publication venues for Roberts include Regulatory Toxicology and Pharmacology, Chemical Research in Toxicology, Critical Reviews in Toxicology, Toxicology Letters, and Computational Toxicology. These venues indicate a consistent engagement with toxicological and pharmacological aspects of dermatology and environmental health.

Notable recent papers authored or co-authored by Roberts include:

  • Skin sensitization in silico protocol (2020) in Regulatory Toxicology and Pharmacology
  • Evaluating confidence in toxicity assessments based on experimental data and in silico predictions (2021) in Computational Toxicology
  • Updating the Dermal Sensitisation Thresholds using an expanded dataset and an in silico expert system (2022) in Regulatory Toxicology and Pharmacology
  • Application of the dermal sensitization threshold concept to chemicals classified as high potency category for skin sensitization assessment of ingredients for consumer products (2020) in Regulatory Toxicology and Pharmacology
  • Chemistry of Isoeugenol and Its Oxidation Products: Mechanism and Kinetics of Isoeugenol as a Skin Sensitizer (2023) in Chemical Research in Toxicology

Collaboration appears as an important component of their work, with frequent co-authors including Martyn L. Chilton, A.M. Api, Candice Johnson, Lennart T. Anger, and Romualdo Benigni. These partnerships reflect a network of researchers focused on toxicology, dermatology, and related disciplines.

Best Publications

  • Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.

    David W. Roberts;Grace Patlewicz;Petra S. Kern;Frank Gerberick

  • Comparison of Cramer classification between Toxtree, the OECD QSAR Toolbox and expert judgment.

    Sneha Bhatia;Terry Schultz;David Roberts;Jie Shen

  • Extension of the Dermal Sensitisation Threshold (DST) approach to incorporate chemicals classified as reactive

    Robert J. Safford;Anne Marie Api;David W. Roberts;Jon F. Lalko

  • Principles for identification of High Potency Category Chemicals for which the Dermal Sensitisation Threshold (DST) approach should not be applied.

    David W. Roberts;Anne Marie Api;Robert J. Safford;Jon F. Lalko

  • Mechanistic Applicability Domains for Nonanimal-Based Prediction of Toxicological End Points: General Principles and Application to Reactive Toxicity

    and Aynur O. Aptula;David W. Roberts

  • Measurement and estimation of electrophilic reactivity for predictive toxicology.

    Johannes A H Schwöbel;Yana K Koleva;Steven J Enoch;Fania Bajot

  • Skin sensitization : Reaction mechanistic applicability domains for structure-activity relationships

    Aynur O Aptula;Grace Patlewicz;David W Roberts

  • Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay.

    David W. Roberts;and Aynur O. Aptula;Grace Patlewicz

  • High Throughput Kinetic Profiling Approach for Covalent Binding to Peptides: Application to Skin Sensitization Potency of Michael Acceptor Electrophiles

    David W. Roberts;Andreas Natsch

  • Determinants of skin sensitisation potential.

    David W. Roberts;Aynur O. Aptula

  • A conceptual framework for predicting the toxicity of reactive chemicals: modeling soft electrophilicity.

    T W Schultz;R E Carlson;M T D Cronin;J L M Hermens

  • Mechanistic Applicability Domains for Non-Animal Based Prediction of Toxicological Endpoints. QSAR Analysis of the Schiff Base Applicability Domain for Skin Sensitization

    David W. Roberts;and Aynur O. Aptula;Grace Patlewicz

  • Towards AOP application – Implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization

    Grace Patlewicz;Chanita Kuseva;Antonia Kesova;Ioanna Popova

  • TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity.

    Grace Patlewicz;Sabcho D. Dimitrov;Lawrence K. Low;Petra S. Kern

  • In silico prediction of aqueous solubility: the solubility challenge.

    Mark Hewitt;Mark T. D. Cronin;Steven J. Enoch;Judith C. Madden

  • Non-enzymatic glutathione reactivity and in vitro toxicity: a non-animal approach to skin sensitization

    Aynur O. Aptula;Grace Patlewicz;David W. Roberts;T.W. Schultz

  • Structure-toxicity relationships for the effects to Tetrahymena pyriformis of aliphatic, carbonyl-containing, alpha,beta-unsaturated chemicals.

    T. Wayne Schultz;Tatiana I. Netzeva;David W. Roberts;Mark T. D. Cronin

  • Skin-sensitization structure-activity relationships for aldehydes.

    Grace Patlewicz;David A. Basketter;Camilla K. Smith;Sharon A. M. Hotchkiss

  • Contact and photocontact allergy to octocrylene: a review

    Anton C. de Groot;David W. Roberts

  • Activation of non‐sensitizing or low‐sensitizing fragrance substances into potent sensitizers – prehaptens and prohaptens

    Ann-Therese Karlberg;Anna Börje;Jeanne Duus Johansen;Carola Lidén

  • An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential

    G. Patlewicz;A. O. Aptula;E. Uriarte;D. W. Roberts

Frequent Co-Authors

Mark T. D. Cronin
Mark T. D. Cronin Liverpool John Moores University
David A. Basketter
David A. Basketter University of Bedfordshire
Jeffrey Penfold
Jeffrey Penfold Rutherford Appleton Laboratory
John C. Dearden
John C. Dearden Liverpool John Moores University
Ian Kimber
Ian Kimber University of Manchester
Eugenio Uriarte
Eugenio Uriarte University of Santiago de Compostela
Zifeng Yan
Zifeng Yan China University of Petroleum, Beijing
Ian R. White
Ian R. White University College London
Raymond R. Tice
Raymond R. Tice National Institutes of Health
Cindy A. Ryan
Cindy A. Ryan Procter & Gamble (United States)

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