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Genetics

D-Index
54
Citations
26516
World Ranking
3605
National Ranking
428

Overview

Colin A. Semple is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine. Within these areas, their work focuses particularly on Molecular Biology, Genetics, Cancer Research, Reproductive Medicine, and Oncology.

The scientist's published work covers several specific topics, including Cancer Genomics and Diagnostics, DNA Repair Mechanisms, Ovarian Cancer Diagnosis and Treatment, PARP Inhibition in Cancer Therapy, Genomics and Rare Diseases, Genomics and Chromatin Dynamics, and BRCA Gene Mutations in Cancer.

Colin A. Semple has contributed extensively to various academic venues. Their frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), where they have published 14 papers, Nature Communications with 6 papers, Genome Research and Clinical Cancer Research with 3 papers each, and Nature with 2 papers.

Several recent papers illustrate the focus of their research:

  • "A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns" (2020) in Nature Communications
  • "Functional annotation of human long noncoding RNAs via molecular phenotyping" (2020) in Genome Research
  • "Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome" (2020) in Nature Communications
  • "Sex differences in oncogenic mutational processes" (2020) in Nature Communications
  • "Pervasive lesion segregation shapes cancer genome evolution" (2020) in Nature

The scientist collaborates with a range of researchers, including Alison Meynert, Ailith Ewing, Vera B. Kaiser, Charlie Gourley, and Martin S. Taylor, each having coauthored multiple works with them.

Best Publications

  • The Transcriptional Landscape of the Mammalian Genome

    P. Carninci;T. Kasukawa;S. Katayama;J. Gough

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

    Y. Okazaki;M. Furuno;T. Kasukawa;J. Adachi

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Genome-wide analysis of mammalian promoter architecture and evolution

    Piero Carninci;Albin Sandelin;Boris Lenhard;Boris Lenhard;Shintaro Katayama

  • Disruption of two novel genes by a translocation co-segregating with schizophrenia

    J. Kirsty Millar;Julie C. Wilson-Annan;Susan Anderson;Sheila Christie

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection.

    Yanick J Crow;Yanick J Crow;Andrea Leitch;Bruce E Hayward;Anna Garner

  • Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

    Albert Tenesa;Susan M Farrington;James G D Prendergast;Mary E Porteous

  • A high-resolution anatomical atlas of the transcriptome in the mouse embryo.

    Graciana Diez-Roux;Sandro Banfi;Marc Sultan;Lars Geffers

  • Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.

    Caroline R.M. Wilkinson;Michael Seeger;Rasmus Hartmann-Petersen;Miranda Stone

  • The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

    Harukazu Suzuki;Alistair R.R. Forrest;Erik Van Nimwegen;Carsten O. Daub

  • Posttranscriptional regulation of miRNAs harboring conserved terminal loops.

    Gracjan Michlewski;Sonia Guil;Colin A. Semple;Javier F. Cáceres

  • Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation

    James Fraser;Carmelo Ferrai;Carmelo Ferrai;Andrea M Chiariello;Markus Schueler

  • Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

    Kate Schroder;Katharine M Irvine;Martin S Taylor;Nilesh J Bokil

  • POCUS: mining genomic sequence annotation to predict disease genes

    Frances S Turner;Daniel R Clutterbuck;Colin A M Semple

  • Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

    Malcolm G Dunlop;Sara E Dobbins;Susan Mary Farrington;Angela M Jones

  • Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis

    Yael Costa;Robert Speed;Rupert Öllinger;Manfred Alsheimer

  • Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells

    Nicola Reynolds;Brian Collier;Klio Maratou;Victoria Bingham

  • Duplication and selection in the evolution of primate β-defensin genes

    Colin A M Semple;Mark Rolfe;Julia R Dorin

Frequent Co-Authors

Martin S. Taylor
Martin S. Taylor Harvard University
David J. Porteous
David J. Porteous University of Edinburgh
Alistair R. R. Forrest
Alistair R. R. Forrest Harry Perkins Institute of Medical Research
Boris Lenhard
Boris Lenhard Imperial College London
Albin Sandelin
Albin Sandelin University of Copenhagen
David A. Hume
David A. Hume University of Queensland

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