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Biology and Biochemistry

D-Index
53
Citations
27319
World Ranking
15882
National Ranking
6596

Overview

Claire H. Mitchell is affiliated with the University of Pennsylvania in the United States. Their research spans multiple areas within medicine, biochemistry, genetics and molecular biology, and neuroscience, reflecting a multidisciplinary approach to biological and medical sciences.

Their work concentrates on several main topics, including:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Adenosine and Purinergic Signaling
  • Retinal Development and Disorders
  • Pain Mechanisms and Treatments
  • Inflammatory mediators and NSAID effects
  • Inflammasome and immune disorders
  • Neuropeptides and Animal Physiology

Within their fields of study, they have contributed to medicine with 31 publications, biochemistry, genetics and molecular biology with 27, and neuroscience with 19. Subfields featuring prominently in their research include molecular biology, physiology, neurology, cellular and molecular neuroscience, and immunology.

Mitchell's recent papers demonstrate a focus on inflammation, cellular signaling, and neurodegeneration. Notable recent publications include:

  • "Nonsteroidal Anti-Inflammatory Drugs and Opioids in Postsurgical Dental Pain" (2020, Journal of Dental Research)
  • "Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration" (2021, Frontiers in Pharmacology)
  • "The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis" (2021, Frontiers in Cellular Neuroscience)
  • "Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium" (2023, Molecular Neurodegeneration)
  • "Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure" (2021, Journal of Neuroinflammation)

Publication venues where Mitchell frequently contributes include bioRxiv (Cold Spring Harbor Laboratory) with 5 publications, Frontiers in Pharmacology with 2, Experimental Eye Research with 2, among others.

The scientist works collaboratively, with frequent co-authors such as Wennan Lu, Puttipong Sripinun, Keith E. Campagno, Katherine N. Theken, and Assraa Hassan Jassim. These partnerships indicate a networked approach to addressing complex biological and medical questions.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

    Ju-Hyun Lee;Mary Kate McBrayer;Devin M. Wolfe;Luke J. Haslett

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • A release mechanism for stored ATP in ocular ciliary epithelial cells

    Claire H. Mitchell;David A. Carré;Alice M. McGlinn;Richard A. Stone

  • Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain.

    Jonathan M. Beckel;Jonathan M. Beckel;Arthur J. Argall;Jason C. Lim;Jingsheng Xia

  • Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP

    Erin E. Coffey;Jonathan M. Beckel;Alan M. Laties;Claire H. Mitchell

  • CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes

    Zhongming Ma;Akiyuki Taruno;Makoto Ohmoto;Masafumi Jyotaki

  • CATSPER Channel-Mediated Ca2+ Entry into Mouse Sperm Triggers a Tail-to-Head Propagation

    Jingsheng Xia;David Reigada;Claire H. Mitchell;Dejian Ren

  • From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma.

    David Križaj;Daniel A. Ryskamp;Ning Tian;Gülgün Tezel

  • Neurons respond directly to mechanical deformation with pannexin‐mediated ATP release and autostimulation of P2X7 receptors

    Jingsheng Xia;Jason C. Lim;Wennan Lu;Jonathan M. Beckel

  • Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.

    Julie Sanderson;Darlene A. Dartt;Vickery Trinkaus-Randall;Jesus Pintor

  • Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells.

    Xiulan Zhang;Mei Zhang;Alan M. Laties;Claire H. Mitchell

  • Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels.

    David Reigada;Wennan Lu;May Zhang;May Zhang;Claire H. Mitchell

  • Autophagy in the Eye: Implications for Ocular Cell Health

    Laura S. Frost;Claire H. Mitchell;Kathleen Boesze-Battaglia

  • Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.

    Ji Liu;Wennan Lu;David Reigada;Jonathan Nguyen

  • Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells

    Gabriel C. Baltazar;Sonia Guha;Wennan Lu;Jason Lim

  • The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.

    Farraj Albalawi;Wennan Lu;Jonathan M. Beckel;Jonathan M. Beckel;Jason C. Lim

  • Release of ATP by a human retinal pigment epithelial cell line: potential for autocrine stimulation through subretinal space.

    Claire H. Mitchell

Frequent Co-Authors

Evelina Gatti
Evelina Gatti Aix-Marseille University
Jean Sévigny
Jean Sévigny Université Laval
Ian G. Mills
Ian G. Mills University of Oxford
Sam Gandy
Sam Gandy Icahn School of Medicine at Mount Sinai
Leonidas C. Platanias
Leonidas C. Platanias Northwestern University
Hsing Jien Kung
Hsing Jien Kung Taipei Medical University
Maurizio Molinari
Maurizio Molinari Universita della Svizzera Italiana
Ralph A. Nixon
Ralph A. Nixon Nathan Kline Institute for Psychiatric Research
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Val C. Sheffield
Val C. Sheffield University of Iowa

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