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Brock C. Christensen

Brock C. Christensen

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
16435
World Ranking
14195
National Ranking
5985

Overview

Brock C. Christensen is affiliated with Dartmouth College in the United States. Their research spans multiple intersecting disciplines with a primary focus on Biochemistry, Genetics, and Molecular Biology, as well as Medicine.

The main subfields of study in Christensen's body of work include Molecular Biology, Oncology, Cancer Research, Immunology, and Pulmonary and Respiratory Medicine. Their research topics cover a broad range related to cancer and molecular mechanisms, including Epigenetics and DNA Methylation, Single-cell and Spatial Transcriptomics, Artificial Intelligence applications in cancer detection, Cancer Genomics and Diagnostics, Immune Cells in Cancer, Cancer Immunotherapy and Biomarkers, and Ferroptosis and Cancer Prognosis.

Christensen has authored numerous papers published in high-impact and specialized scientific journals. Among the recent works are:

  • Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling, 2022, Nature Communications
  • Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation, 2020, Nature Communications
  • Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer, 2022, Science Advances
  • MethylNet: an automated and modular deep learning approach for DNA methylation analysis, 2020, BMC Bioinformatics
  • Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell-type deconvolution applied to human blood epigenetic clocks, 2023, Aging Cell

Frequent co-authors in Christensen's research network include Lucas A. Salas, Joshua Levy, Louis Vaickus, Karl T. Kelsey, and Devin C. Koestler. Collaborations with these scholars indicate active involvement in multi-author studies with significant publication output.

Christensen's publications often appear in prominent venues such as bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Clinical Epigenetics, Epigenomics, and Epigenetics, signifying a strong presence in both preliminary preprint archives and peer-reviewed journals focused on cancer and epigenetics.

Best Publications

  • DNA methylation arrays as surrogate measures of cell mixture distribution

    Eugene Andres Houseman;William P Accomando;Devin C Koestler;Brock C Christensen

  • Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

    Brock C. Christensen;E. Andres Houseman;E. Andres Houseman;Carmen J. Marsit;Shichun Zheng

  • DNA methylation aging clocks: challenges and recommendations

    Christopher G Bell;Robert Lowe;Peter D Adams;Peter D Adams;Andrea A Baccarelli

  • MicroRNA Expression Ratio Is Predictive of Head and Neck Squamous Cell Carcinoma

    Michele Avissar;Brock C. Christensen;Karl T. Kelsey;Carmen J. Marsit

  • An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray.

    Lucas A. Salas;Devin C. Koestler;Rondi A. Butler;Helen M. Hansen

  • DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma

    Brock C. Christensen;Ashley A. Smith;Shichun Zheng;Devin C. Koestler

  • Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis.

    Devin C Koestler;Brock C Christensen;Margaret R Karagas;Carmen J Marsit

  • A let-7 microRNA-binding site polymorphism in the KRAS 3′ UTR is associated with reduced survival in oral cancers

    Brock C. Christensen;Benjamin J. Moyer;Michele Avissar;Lauren G. Ouellet

  • Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions

    E. Andres Houseman;E. Andres Houseman;Brock C. Christensen;Ru-Fang Yeh;Carmen J. Marsit

  • Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner

    Sara N. Lundgren;Juliette C. Madan;Juliette C. Madan;Jennifer A. Emond;Hilary G. Morrison

  • Review of processing and analysis methods for DNA methylation array data

    Charlotte Wilhelm-Benartzi;D. C. Koestler;M. R. Karagas;J. M. Flanagan

  • Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis

    Thomas Fleischer;Arnoldo Frigessi;Kevin C. Johnson;Hege Edvardsen

  • Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake

    Brock C. Christensen;Karl T. Kelsey;Shichun Zheng;E. Andres Houseman

  • Cell-type deconvolution from DNA methylation: a review of recent applications.

    Alexander J. Titus;Rachel M. Gallimore;Lucas A. Salas;Brock C. Christensen

  • Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL).

    Devin C. Koestler;Meaghan J. Jones;Joseph Usset;Brock C. Christensen

  • Biomarkers of HPV in head and neck squamous cell carcinoma

    Caihua Liang;Carmen J. Marsit;Michael D. McClean;Heather H. Nelson

  • Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome

    Brock C. Christensen;E. A. Houseman;E. A. Houseman;E. A. Houseman;John J. Godleski;Carmen J. Marsit

  • Mature MicroRNA Sequence Polymorphism in MIR196A2 Is Associated with Risk and Prognosis of Head and Neck Cancer

    Brock C. Christensen;Michele Avissar-Whiting;Lauren G. Ouellet;Rondi A. Butler

  • Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm.

    Sara E. Pacheco;E. Andres Houseman;Brock C. Christensen;Carmen J. Marsit

  • Abstract 878: DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma

    Brock C. Christensen;Ashley A. Smith;Shichun Zheng;Devin C. Koestler

Frequent Co-Authors

Karl T. Kelsey
Karl T. Kelsey Brown University
Carmen J. Marsit
Carmen J. Marsit Emory University
E. Andres Houseman
E. Andres Houseman Oregon State University
John K. Wiencke
John K. Wiencke University of California, San Francisco
Margaret R. Karagas
Margaret R. Karagas Dartmouth College
Margaret R. Wrensch
Margaret R. Wrensch University of California, San Francisco
Joseph L. Wiemels
Joseph L. Wiemels University of Southern California
David J. Sugarbaker
David J. Sugarbaker Baylor College of Medicine
Raphael Bueno
Raphael Bueno Brigham and Women's Hospital
Paige M. Bracci
Paige M. Bracci University of California, San Francisco

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