Bent K Jakobsen

Best Publications

• Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

  Gerald P. Linette;Edward A. Stadtmauer;Marcela V. Maus;Aaron P. Rapoport

  1317
  Citations

• NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma

  Aaron P Rapoport;Edward A Stadtmauer;Gwendolyn K Binder-Scholl;Olga Goloubeva

  961
  Citations

• Monoclonal TCR-redirected tumor cell killing

  Nathaniel Liddy;Giovanna Bossi;Katherine J. Adams;Anna Lissina

  795
  Citations

• Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells

  Brian J. Cameron;Andrew B. Gerry;Joseph Dukes;Jane V. Harper

  755
  Citations

• Stable, soluble T-cell receptor molecules for crystallization and therapeutics.

  Jonathan M. Boulter;Meir Glick;Penio T. Todorov;Emma Baston

  747
  Citations

• Directed evolution of human T-cell receptors with picomolar affinities by phage display.

  Yi Li;Ruth Moysey;Peter E Molloy;Anne-Lise Vuidepot

  682
  Citations

• Crystal structure of the complex between human CD8αα and HLA-A2

  G F Gao;J Tormo;U C Gerth;Wyer

  598
  Citations

• Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.

  B E Willcox;G F Gao;Wyer;C A O'Callaghan

  517
  Citations

• Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions

  Paul F. Robbins;Yong F. Li;Mona El-Gamil;Yangbing Zhao

  461
  Citations

• TCR binding to peptide-MHC stabilizes a flexible recognition interface.

  Benjamin E. Willcox;George F. Gao;Jessica R. Wyer;John Edward Simon Durham Ladbury

  380
  Citations

• Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines

  Ji-Li Chen;Guillaume Stewart-Jones;Giovanna Bossi;Nikolai M. Lissin

  330
  Citations

• Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

  Angel Varela-Rohena;Peter E. Molloy;Steven M. Dunn;Yi Li

  306
  Citations

• Different affinity windows for virus and cancer-specific T-cell receptors – implications for therapeutic strategies

  Milos Aleksic;Nathaniel Liddy;Peter E. Molloy;Nick Pumphrey

  290
  Citations

• T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.

  Wyer;B E Willcox;G F Gao;U C Gerth

  290
  Citations

• High-Affinity TCRs Generated by Phage Display Provide CD4+ T Cells with the Ability to Recognize and Kill Tumor Cell Lines

  Yangbing Zhao;Alan D. Bennett;Zhili Zheng;Qiong J. Wang

  270
  Citations

• Human TCR-binding affinity is governed by MHC class restriction.

  David K. Cole;Nicholas J. Pumphrey;Jonathan M. Boulter;Malkit Sami

  269
  Citations

• Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor

  George F Gao;Bent K Jakobsen

  244
  Citations

• Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.

  Anna Marta Bulek;David Cole;Ania Skowera;Ania Skowera;Garry Michael Dolton

  242
  Citations

• Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E

  C A O'Callaghan;J Tormo;B E Willcox;B E Willcox;V M Braud

  235
  Citations

• The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

  M. A. Purbhoo;J. M. Boulter;David Price;A.-L. Vuidepot

  228
  Citations