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Alain Gratton

Alain Gratton

D-Index & Metrics

Neuroscience

D-Index
52
Citations
9033
World Ranking
5363
National Ranking
314

Overview

Alain Gratton is affiliated with McGill University in Canada. Their research primarily spans the fields of Medicine and Neuroscience, with a focus on various subfields such as Cellular and Molecular Neuroscience, Molecular Biology, Pharmacology, Pediatrics, Perinatology and Child Health, and Epidemiology.

Their recent scholarly output includes several papers published in respected academic venues. Notable publications are:

  • Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating, 2020, Journal of Clinical Investigation
  • Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells, 2021, Stem Cell Reports
  • Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells, 2020, Stem Cells Translational Medicine
  • Investigating the "two-hit hypothesis": Effects of prenatal maternal immune activation and adolescent cannabis use on neurodevelopment in mice, 2022, Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • Efficacy of prophylactic versus therapeutic administration of the NMDA receptor antagonist MK-801 on the acute neurochemical response to a concussion in a rat model combining force and rotation, 2021, Journal of neurosurgery

The venues in which they have published include:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Stem Cell Reports
  • Journal of Clinical Investigation
  • Stem Cells Translational Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry

Frequent coauthors contributing alongside Alain Gratton include:

  • Luc Moquin
  • Daniel Gallino
  • M. Mallar Chakravarty
  • Elisa Guma
  • Lani Cupo

The primary research topics explored by Gratton feature:

  • Cannabis and Cannabinoid Research
  • Prenatal Substance Exposure Effects
  • Neuroscience and Neuropharmacology Research
  • Neurotransmitter Receptor Influence on Behavior
  • Neuroscience of respiration and sleep
  • Traumatic Brain Injury Research
  • Traumatic Brain Injury and Neurovascular Disturbances

Overall, the body of work reflects a strong engagement with neurobiological mechanisms related to behavior, neurodevelopmental impacts of substance exposure, and neuropharmacological interventions, as well as clinical and translational neuroscience investigations.

Best Publications

  • Lateralized Effects of Medial Prefrontal Cortex Lesions on Neuroendocrine and Autonomic Stress Responses in Rats

    Ron M. Sullivan;Alain Gratton

  • Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse?

    Michael J Meaney;Wayne Brake;Alain Gratton

  • Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats.

    Wayne G. Brake;Tie Yuan Zhang;Josie Diorio;Michael J. Meaney

  • Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

    Frances A. Champagne;Pablo Chretien;Carl W. Stevenson;Tie Yuan Zhang

  • Oxytocin-Dopamine Interactions Mediate Variations in Maternal Behavior in the Rat

    Dara K. Shahrokh;Tie-Yuan Zhang;Josie Diorio;Alain Gratton

  • Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.

    Adolfo Sequeira;Firoza Mamdani;Carl Ernst;Marquis P. Vawter

  • Prefrontal cortical regulation of hypothalamic-pituitary-adrenal function in the rat and implications for psychopathology: side matters.

    Ron M. Sullivan;Ron M. Sullivan;Alain Gratton

  • Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers

    Carl Ernst;Vesselina Deleva;Xiaoming Deng;Adolfo Sequeira

  • A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal

    Ian D Blum;Lei Zhu;Lei Zhu;Luc Moquin;Maia V Kokoeva

  • Partial dopamine depletion of the prefrontal cortex leads to enhanced mesolimbic dopamine release elicited by repeated exposure to naturally reinforcing stimuli

    JB Mitchell;A Gratton

  • Behavioral effects of excitotoxic lesions of ventral medial prefrontal cortex in the rat are hemisphere-dependent.

    Ron M. Sullivan;Alain Gratton

  • Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats

    Unknown

  • Electrochemical monitoring of extracellular dopamine in nucleus accumbens of rats lever-pressing for food

    Eugene A. Kiyatkin;Alain Gratton

  • Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons

    Elsa Isingrini;Léa Perret;Quentin Rainer;Bénédicte Amilhon

  • Relationships between stress-induced increases in medial prefrontal cortical dopamine and plasma corticosterone levels in rats: role of cerebral laterality

    R.M. Sullivan;A. Gratton

  • Behavior-Relevant Changes in Nucleus Accumbens Dopamine Transmission Elicited by Food Reinforcement: An Electrochemical Study in Rat

    Unknown

  • In vivo electrochemical studies of monoamine release in the medial prefrontal cortex of the rat

    A. Gratton;B.J. Hoffer;G.A. Gerhardt

  • Opioid modulation and sensitization of dopamine release elicited by sexually relevant stimuli: a high speed chronoamperometric study in freely behaving rats.

    John B. Mitchell;Alain Gratton

  • Perinatal Distress Leads to Lateralized Medial Prefrontal Cortical Dopamine Hypofunction in Adult Rats

    Unknown

  • Possible involvement of medial prefrontal cortex in amphetamine-induced sensitization of mesolimbic dopamine function

    Kate E. Banks;Alain Gratton

  • Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous heroin self-administration in rats

    Eugene A. Kiyatkin;Roy A. Wise;Alain Gratton

  • Effects of local delta and mu opioid receptor activation on basal and stimulated dopamine release in striatum and nucleus accumbens of rat: an in vivo electrochemical study.

    R.J.W. Pentney;A. Gratton

  • Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex

    Erin R. Hascup;Kevin N. Hascup;Michelle Stephens;Francois Pomerleau

Frequent Co-Authors

Greg A. Gerhardt
Greg A. Gerhardt University of Kentucky
Bruno Giros
Bruno Giros McGill University
Greg M. Rose
Greg M. Rose United States Department of Veterans Affairs
Eugene A. Kiyatkin
Eugene A. Kiyatkin National Institute on Drug Abuse
Roy A. Wise
Roy A. Wise National Institute on Drug Abuse
Barry J. Hoffer
Barry J. Hoffer Case Western Reserve University
Naguib Mechawar
Naguib Mechawar McGill University
Timothy W. Bredy
Timothy W. Bredy University of Queensland
Hyder A. Jinnah
Hyder A. Jinnah Emory University
Jean-Paul Soucy
Jean-Paul Soucy Montreal Neurological Institute and Hospital

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