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Nucleic Acid Therapeutics
H-index 20

Nucleic Acid Therapeutics

2159-3337

Published by: Mary Ann Liebert, Inc. Publishers

https://home.liebertpub.com/publications/nucleic-acid-therapeutics/601/overview

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Molecular Biology 101 19 24 10
Genetics 106 12 19 9
Biology and Biochemistry 432 32 48 15
Chemistry 819 12 17 8
Medicine 2539 30 28 9

Additional Metrics

Number of Best Scientists*: 107
Documents by Best Scientists*: 107
Top 100 Ranked Scientists*: 3
SCIMAGO H-index: 81
SCIMAGO SJR: 1.499
Impact Factor: 4.7

Overview

Top Research Topics at Nucleic Acid Therapeutics?

Nucleic Acid Therapeutics investigates studies in Oligonucleotide, Molecular biology, RNA, Aptamer and Cell biology. While Oligonucleotide is the focus of it, it also provided insights into the studies of Computational biology, Nucleic acid and Pharmacology. It addresses concerns in the field of Molecular biology by exploring it in line with topics in Cell culture which intersect with Cell growth subjects.

Small interfering RNA and RNA interference are all subfields of RNA research that were featured in the journal. While the primary focus in Nucleic Acid Therapeutics is Small interfering RNA, it also dissects topics surrounding Cancer research and Cancer and Metastasis as a whole. RNA interference research presented falls under the umbrella topic of Genetics.

The research on Aptamer tackled can also make contributions to studies in the areas of SELEX Aptamer Technique, Systematic evolution of ligands by exponential enrichment, Cancer cell, Biophysics and DNA. The journal tackles studies in Gene silencing and the interrelated subject of microRNA to gain insights into Cell biology. Biochemistry works presented in the journal have a specific focus on Plasma protein binding.

  • Oligonucleotide (27.74%)
  • Molecular biology (27.31%)
  • RNA (21.08%)

What are the most cited papers published in the journal?

  • Phosphorothioates, essential components of therapeutic oligonucleotides. (248 citations)
  • FDA Approves Eteplirsen for Duchenne Muscular Dystrophy: The Next Chapter in the Eteplirsen Saga. (184 citations)
  • RNA Sequencing: Platform Selection, Experimental Design, and Data Interpretation (153 citations)

Research areas of the most cited articles at Nucleic Acid Therapeutics:

The journal articles generally zeroe in on subjects such as Oligonucleotide, RNA, Molecular biology, Computational biology and Aptamer. The journal publications with studies in Oligonucleotide featured incorporate elements of Nucleic acid and Pharmacology. The most cited articles explore issues in RNA which can be linked to other research areas like Messenger RNA, In vivo and Nuclease.

What topics the last edition of the journal is best known for?

  • Gene
  • DNA
  • Enzyme

The previous edition focused in particular on these issues:

The main research concerns discussed in the journal are RNA, Oligonucleotide, Cell biology, Antisense oligonucleotides and Computational biology. The research on RNA featured in Nucleic Acid Therapeutics combines topics in other fields like Gene silencing, In vivo and Folate receptor. The research topics discussed in it include Oligonucleotide as well as Stable Isotope Labeling.

Nucleic Acid Therapeutics holds forums on Cell biology that merges themes from other disciplines such as Gene knockdown, Exon skipping, Downregulation and upregulation, Duchenne muscular dystrophy and Exon. It explores research in Computational biology alongside concepts in Nucleic acid and other areas of study in Gene expression, Hepatocyte and Drug delivery. Some problems in Small interfering RNA that were presented in it overlapped with concepts under Biophysics, RNA interference and Ligand (biochemistry).

The most cited articles from the last journal are:

  • Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective. (3 citations)
  • Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides. (3 citations)
  • Human Papillomavirus G-Rich Regions as Potential Antiviral Drug Targets (3 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Nucleic Acid Therapeutics (based on the number of publications) are:

  • Scott P. Henry (19 papers) published 1 paper at the last edition, 3 less than at the previous edition,
  • Annemieke Aartsma-Rus (15 papers) published 2 papers at the last edition the same number as at the previous edition,
  • Richard S. Geary (13 papers) published 2 papers at the last edition, 1 less than at the previous edition,
  • David R. Corey (13 papers) absent at the last edition,
  • Bruce A. Sullenger (11 papers) absent at the last edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Nucleic Acid Therapeutics (based on the number of publications) are:

  • Isis Pharmaceuticals (26 papers) published 2 papers at the last edition, 1 less than at the previous edition,
  • Leiden University Medical Center (20 papers) published 3 papers at the last edition, 1 more than at the previous edition,
  • University of Texas Southwestern Medical Center (13 papers) absent at the last edition,
  • Duke University (10 papers) absent at the last edition,
  • Alnylam Pharmaceuticals (8 papers) published 1 paper at the last edition, 2 less than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 11.36% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 28.21% were posted by at least one author from the top 10 institutions publishing in the journal. Another 12.82% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 20.51% of all publications and 38.46% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Top Publications

  • Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study.

    Wesley Tyler Abplanalp;Ariane Fischer;David John;Andreas M Zeiher

    (2020)
    111 Citations
  • Delivery of RNA Therapeutics: The Great Endosomal Escape!

    (2022)
    107 Citations
  • The 10th Oligonucleotide Therapy Approved: Golodirsen for Duchenne Muscular Dystrophy.

    Annemieke Aartsma-Rus;David R. Corey

    (2020)
    97 Citations
  • Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial

    Laurent Servais;Laurent Servais;Eugenio Mercuri;Volker Straub;Michela Guglieri

    (2021)
    84 Citations
  • Challenges and Opportunities for Nucleic Acid Therapeutics.

    (2021)
    69 Citations
  • Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs

    (2023)
    68 Citations
  • Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides.

    Erle M Holgersen;Shreshth Gandhi;Yongchao Zhou;Jinkuk Kim

    (2021)
    60 Citations

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