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Human Gene Therapy
H-index 30

Human Gene Therapy

1043-0342

Published by: Mary Ann Liebert, Inc. Publishers

https://home.liebertpub.com/publications/human-gene-therapy/19

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Genetics 59 27 35 17
Microbiology 213 21 22 9
Medicine 961 68 151 24

Additional Metrics

Number of Best Scientists*: 292
Documents by Best Scientists*: 330
Top 100 Ranked Scientists*: 10
SCIMAGO H-index: 163
SCIMAGO SJR: 1.137
Impact Factor: 4

Overview

Top Research Topics at Human Gene Therapy?

The journal primarily tackles Genetic enhancement, Molecular biology, Virology, Immunology and Viral vector. Human Gene Therapy addresses concerns in Genetic enhancement which are intertwined with other disciplines, such as Transgene, Cancer research, Transduction (genetics) and In vivo. In addition to Cancer research research, the journal aims to explore topics under Cancer and Pathology.

The Transduction (genetics) study featured in it draws parallels with the field of Cell biology. Studies on In vivo discussed in the journal link to the field of In vitro. Molecular biology research featured in it incorporates concerns from various other topics such as Plasmid, Cell culture, Transfection, Gene expression and Recombinant DNA.

While the journal focused on Virology, it was also able to explore topics like Vector (molecular biology), Adeno-associated virus, Adenoviridae and Recombinant virus. While Immunology is the focus of Human Gene Therapy, it also provided insights into the studies of Genetic transfer and Stem cell. It investigates Viral vector research which frequently intersects with Gene delivery.

  • Genetic enhancement (40.45%)
  • Molecular biology (26.21%)
  • Virology (22.03%)

What are the most cited papers published in the journal?

  • High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. (860 citations)
  • Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial (821 citations)
  • Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. (754 citations)

Research areas of the most cited articles at Human Gene Therapy:

The journal articles focus largely on the fields of Genetic enhancement, Molecular biology, Virology, Immunology and Viral vector. The journal publications with studies in Genetic enhancement featured incorporate elements of Vector (molecular biology), Cancer research and Transgene. In addition to Molecular biology research, the journal publications aim to explore topics under Plasmid, Gene expression, Transfection, Transduction (genetics) and In vivo.

What topics the last edition of the journal is best known for?

  • Gene
  • Internal medicine
  • Enzyme

The previous edition focused in particular on these issues:

The scientific interests tackled in the journal are Genetic enhancement, Cancer research, Adeno-associated virus, Gene and Viral vector. The work on Genetic enhancement tackled in it brings together disciplines like Transgene, Bioinformatics, Vector (molecular biology), Immunology and Cell biology. The research on Cell biology tackled can also make contributions to studies in the areas of Cell and Transduction (genetics).

In the journal, T cell, Apoptosis and In vivo are investigated in conjunction with one another to address concerns in Cancer research research. While work presented in Human Gene Therapy provided substantial information on Adeno-associated virus, it also covered topics in Virus, Capsid, Molecular biology, Antibody and Gene delivery. Gene research in it involves the investigation of Computational biology studies, all of which are linked to disciplines such as Genome.

The most cited articles from the last journal are:

  • Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MicroRNA-150-3p Promotes Osteoblast Proliferation and Differentiation in Osteoporosis. (10 citations)
  • Capillary Electrophoresis-Sodium Dodecyl Sulfate with Laser-Induced Fluorescence Detection as a Highly Sensitive and Quality Control-Friendly Method for Monitoring Adeno-Associated Virus Capsid Protein Purity. (8 citations)
  • miR-375- and miR-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity But Strong Antitumor Efficiency in Colorectal Carcinomas. (7 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Human Gene Therapy (based on the number of publications) are:

  • James M. Wilson (122 papers) published 3 papers at the last edition the same number as at the previous edition,
  • Terence R. Flotte (92 papers) published 9 papers at the last edition, 3 less than at the previous edition,
  • Ronald G. Crystal (76 papers) published 2 papers at the last edition, 4 less than at the previous edition,
  • W. French Anderson (64 papers) absent at the last edition,
  • Guangping Gao (51 papers) published 4 papers at the last edition, 2 more than at the previous edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Human Gene Therapy (based on the number of publications) are:

  • National Institutes of Health (219 papers) published 7 papers at the last edition, 3 more than at the previous edition,
  • University of Pennsylvania (163 papers) published 5 papers at the last edition, 3 less than at the previous edition,
  • Baylor College of Medicine (108 papers) absent at the last edition,
  • University of Florida (105 papers) published 2 papers at the last edition, 5 less than at the previous edition,
  • University of Washington (91 papers) published 4 papers at the last edition, 3 more than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 19.63% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 20.61% were posted by at least one author from the top 10 institutions publishing in the journal. Another 16.79% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 17.56% of all publications and 45.04% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Top Publications

  • Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy

    James M Wilson;Terence R Flotte

    (2020)
    189 Citations
  • Adeno-Associated Virus-Induced Dorsal Root Ganglion Pathology.

    Juliette Hordeaux;Elizabeth L. Buza;Cecilia Dyer;Tamara Goode

    (2020)
    169 Citations
  • Global Seroprevalence of Pre-existing Immunity Against AAV5 and Other AAV Serotypes in People with Hemophilia A

    (2022)
    98 Citations
  • Adeno-Associated Virus Serotype-Specific Inverted Terminal Repeat Sequence Role in Vector Transgene Expression

    Lauriel F. Earley;Laura M. Conatser;Victoria M. Lue;Amanda L. Dobbins

    (2020)
    81 Citations
  • Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B.

    Ana Rita Batista;Oliver D King;Christopher P Reardon;Crystal Davis

    (2020)
    75 Citations
  • High-Throughput In Vitro, Ex Vivo, and In Vivo Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction

    Adrian Westhaus;Adrian Westhaus;Marti Cabanes-Creus;Arkadiusz Rybicki;Grober Baltazar

    (2020)
    72 Citations
  • Human and insect cell-produced rAAVs show differences in genome heterogeneity.

    (2022)
    67 Citations
  • Choosing the Right Tool for Genetic Engineering: Clinical Lessons from Chimeric Antigen Receptor-T Cells

    Melita Irving;Evripidis Lanitis;Denis Migliorini;Denis Migliorini;Zoltán Ivics

    (2021)
    66 Citations
  • Efficacy and Safety of a Krabbe Disease Gene Therapy

    (2022)
    63 Citations

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