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Yoshinori Akiyama

Yoshinori Akiyama

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
11467
World Ranking
9399
National Ranking
636

Overview

Yoshinori Akiyama is affiliated with Kyoto University in Japan and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans a diverse range of subfields including molecular biology, genetics, neurology, pulmonary and respiratory medicine, and epidemiology.

Their main research topics cover bacterial genetics and biotechnology, RNA and protein synthesis mechanisms, cerebrovascular and carotid artery diseases, acute ischemic stroke management, glycosylation and glycoproteins research, enzyme structure and function, and intracranial aneurysms: treatment and complications.

Frequent co-authors who have collaborated on multiple publications with Akiyama include:

  • Yohei Hizukuri (13 publications)
  • Ryoji Miyazaki (12 publications)
  • Tatsuhiko Yokoyama (8 publications)
  • Hiroyuki Mori (8 publications)
  • Motoaki Fujimoto (7 publications)

They have published multiple papers in notable scientific venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory) - 6 publications
  • Journal of Biological Chemistry - 4 publications
  • Neurologia medico-chirurgica - 4 publications
  • World Neurosurgery - 3 publications
  • Science Advances - 2 publications

Among their recent papers are:

  • Association Between Alberta Stroke Program Early Computed Tomography Score and Efficacy and Safety Outcomes With Endovascular Therapy in Patients With Stroke From Large-Vessel Occlusion, 2022, JAMA Neurology
  • Cryo-EM structure of the entire FtsH-HflKC AAA protease complex, 2022, Cell Reports
  • Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion, 2021, Acta Crystallographica Section D Structural Biology
  • The Escherichia coli S2P intramembrane protease RseP regulates ferric citrate uptake by cleaving the sigma factor regulator FecR, 2021, Journal of Biological Chemistry
  • Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP, 2022, Science Advances

Yoshinori Akiyama's work emphasizes molecular mechanisms underlying enzymatic processes, bacterial genetics, and clinical neurological conditions, particularly stroke management and cerebrovascular diseases. The integration of structural biology techniques and clinical research is evident in the variety of scientific journals and topics addressed throughout their academic output.

Best Publications

  • CELLULAR FUNCTIONS, MECHANISM OF ACTION, AND REGULATION OF FTSH PROTEASE

    Koreaki Ito;Yoshinori Akiyama

  • Identification and characterization of an Escherichia coli gene required for the formation of correctly folded alkaline phosphatase, a periplasmic enzyme.

    S. Kamitani;Y. Akiyama;K. Ito

  • FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit.

    Akio Kihara;Yoshinori Akiyama;Koreaki Ito

  • Effects of mutations in heat-shock genes groES and groEL on protein export in Escherichia coli.

    N. Kusukawa;T. Yura;C. Ueguchi;Y. Akiyama

  • Topology analysis of the SecY protein, an integral membrane protein involved in protein export in Escherichia coli.

    Y Akiyama;K Ito

  • Expression of SR-PSOX, a Novel Cell-Surface Scavenger Receptor for Phosphatidylserine and Oxidized LDL in Human Atherosclerotic Lesions

    Manabu Minami;Noriaki Kume;Takeshi Shimaoka;Hiroharu Kataoka

  • The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals.

    Yasuko Akiyama;Toshihiko Hosoya;Anthony M. Poole;Yoshiki Hotta

  • FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins.

    Yoshinori Akiyama;Akio Kihara;Hajime Tokuda;Koreaki Ito

  • Involvement of FtsH in protein assembly into and through the membrane. I. Mutations that reduce retention efficiency of a cytoplasmic reporter

    Yoshinori Akiyama;Teru Ogura;Koreaki Ito

  • RseP (YaeL), an Escherichia coli RIP protease, cleaves transmembrane sequences

    Yoshinori Akiyama;Kazue Kanehara;Koreaki Ito

  • A protease complex in the Escherichia coli plasma membrane: HflKC (HflA) forms a complex with FtsH (HflB), regulating its proteolytic activity against SecY.

    A Kihara;Y Akiyama;K Ito

  • SecY protein, a membrane-embedded secretion factor of E. coli, is cleaved by the ompT protease in vitro.

    Yoshinori Akiyama;Koreaki Ito

  • Subunit a of proton ATPase F0 sector is a substrate of the FtsH protease in Escherichia coli.

    Yoshinori Akiyama;Akio Kihara;Koreaki Ito

  • Cell growth and lambda phage development controlled by the same essential Escherichia coli gene, ftsH/hflB.

    Christophe Herman;Teru Ogura;Toshifumi Tomoyasu;Sota Hiraga

  • The SecY membrane component of the bacterial protein export machinery: analysis by new electrophoretic methods for integral membrane proteins.

    Y Akiyama;K Ito

  • In vitro catalysis of oxidative folding of disulfide-bonded proteins by the Escherichia coli dsbA (ppfA) gene product.

    Y Akiyama;S Kamitani;N Kusukawa;K Ito

  • Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA

    Akio Kihara;Yoshinori Akiyama;Koreaki Ito

  • The Cpx stress response system of Escherichia coli senses plasma membrane proteins and controls HtpX, a membrane protease with a cytosolic active site

    Nobuyuki Shimohata;Shinobu Chiba;Naoya Saikawa;Koreaki Ito

  • Host regulation of lysogenic decision in bacteriophage lambda : transmembrane modulation of FtsH (HflB), the cII degrading protease, by HflKC (HflA)

    Akio Kihara;Yoshinori Akiyama;Koreaki Ito

  • Proteolytic Activity of HtpX, a Membrane-bound and Stress-controlled Protease from Escherichia coli

    Machiko Sakoh;Koreaki Ito;Yoshinori Akiyama

Frequent Co-Authors

Koreaki Ito
Koreaki Ito Kyoto Sangyo University
Nobuo Hashimoto
Nobuo Hashimoto Kyoto University
Akio Kihara
Akio Kihara Hokkaido University
Susumu Miyamoto
Susumu Miyamoto Kyoto University
Takashi Yura
Takashi Yura Kyoto University
Junichi Takagi
Junichi Takagi Osaka University
Teru Ogura
Teru Ogura Kumamoto University
Yasushi Ishihama
Yasushi Ishihama Kyoto University
Jon Beckwith
Jon Beckwith Harvard University
Richard Calendar
Richard Calendar University of California, Berkeley

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