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Neuroscience
Austria
2023

D-Index & Metrics

Neuroscience

D-Index
122
Citations
62497
World Ranking
361
National Ranking
25

Medicine

D-Index
126
Citations
64541
World Ranking
2936
National Ranking
157

Research.com Recognitions

  • 2023 - Research.com Neuroscience in Austria Leader Award
  • 2022 - Research.com Neuroscience in Austria Leader Award

Overview

Wolfgang Löscher is affiliated with the University of Veterinary Medicine Hannover, Foundation in Germany. Their research primarily focuses on epilepsy and related neurological conditions, with a strong emphasis on pharmacology and the mechanisms underlying drug resistance and treatment efficacy.

Their work spans several main fields including medicine, with 134 publications, and neuroscience, with 59 publications. Within these broad areas, their subfields of study include psychiatry and mental health, pediatrics, perinatology and child health, cellular and molecular neuroscience, molecular biology, and oncology.

The main topics addressed in their research include epilepsy research and treatment, with 102 publications, neuroscience and neuropharmacology research, pharmacological effects and toxicity studies, neonatal and fetal brain pathology, drug transport and resistance mechanisms, anesthesia and neurotoxicity research, and barrier structure and function studies.

Wolfgang Löscher has contributed frequently to a variety of scientific journals. Their most common publication venues are:

  • Epilepsia
  • Epilepsy & Behavior
  • Neuropharmacology
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Neurobiology of Disease

Some of their recent papers include:

  • "Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options," 2020, Pharmacological Reviews
  • "The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond," 2021, CNS Drugs
  • "Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?", 2020, International Journal of Molecular Sciences
  • "Single-Target Versus Multi-Target Drugs Versus Combinations of Drugs With Multiple Targets: Preclinical and Clinical Evidence for the Treatment or Prevention of Epilepsy," 2021, Frontiers in Pharmacology
  • "Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?", 2020, Epilepsia

Wolfgang Löscher has collaborated frequently with several co-authors including Pavel Klein, Birthe Gericke, Marie Johne, Kerstin Römermann, and Björn Welzel. These collaborations have contributed to advancing research and expanding knowledge in the field of epilepsy and neuropharmacology.

Best Publications

  • The neurobiology of antiepileptic drugs.

    Michael A. Rogawski;Wolfgang Löscher

  • Blood-Brain Barrier Active Efflux Transporters: ATP-Binding Cassette Gene Family

    Wolfgang Löscher;Heidrun Potschka

  • Drug resistance in brain diseases and the role of drug efflux transporters

    Wolfgang Löscher;Heidrun Potschka

  • Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs.

    Wolfgang Löscher

  • Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

    Wolfgang Löscher;Dieter Schmidt

  • Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.

    Wolfgang Löscher

  • Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind …

    Unknown

  • Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study

    James F Howard;Kimiaki Utsugisawa;Michael Benatar;Hiroyuki Murai

  • The blood-brain barrier and cancer: transporters, treatment, and Trojan horses.

    John F. Deeken;Wolfgang Löscher

  • Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options.

    Wolfgang Löscher;Heidrun Potschka;Sanjay M. Sisodiya;Annamaria Vezzani

  • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

    Wolfgang Löscher;Heidrun Potschka

  • New avenues for anti-epileptic drug discovery and development

    Wolfgang Löscher;Henrik Klitgaard;Roy E. Twyman;Dieter Schmidt

  • Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models …

    Unknown

  • Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy.

    Wolfgang Löscher

  • Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

    Wolfgang Löscher

  • Drug resistance in epilepsy : Putative neurobiologic and clinical mechanisms

    Dieter Schmidt;Wolfgang Löscher

  • Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma.

    Wolfgang Löscher;Dieter Schmidt

  • Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs

    Wolfgang Löscher;Heidrun Potschka

  • The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions

    Michael A Rogawski;Wolfgang Löscher

  • The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models.

    Wolfgang Löscher;Dagmar Hönack;Christian P Fassbender;Björn Nolting

  • Infections, inflammation and epilepsy

    Annamaria Vezzani;Robert S. Fujinami;H. Steve White;Pierre Marie Preux

  • The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models.

    Wolfgang Löscher;Christian P Fassbender;Björn Nolting

Frequent Co-Authors

Ulrich Ebert
Ulrich Ebert University of Tübingen
Heidrun Potschka
Heidrun Potschka Ludwig-Maximilians-Universität München
Dieter Schmidt
Dieter Schmidt Freie Universität Berlin
Claudia Brandt
Claudia Brandt University of Veterinary Medicine Hannover, Foundation
José N. Nobrega
José N. Nobrega Centre for Addiction and Mental Health
Werner Poewe
Werner Poewe Innsbruck Medical University
Birgit Högl
Birgit Högl Innsbruck Medical University
Eugen Trinka
Eugen Trinka Paracelsus Medical University
Markus Kofler
Markus Kofler Innsbruck Medical University
Markus Reindl
Markus Reindl Innsbruck Medical University

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