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D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
15678
World Ranking
16468
National Ranking
5

Overview

Tõnis Timmusk is affiliated with Tallinn University of Technology in Estonia. Their research spans several interconnected fields primarily focusing on molecular biology, genetics, neuroscience, and medicine.

The scientist's body of work includes publications concentrated in the following main fields of study:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Neuroscience

Within these broader areas, Timmusk has contributed substantially to subfields such as:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Genetics
  • Physiology
  • Infectious Diseases

Timmusk's research topics focus on themes including:

  • Nerve injury and regeneration
  • Ubiquitin and proteasome pathways
  • Nuclear Receptors and Signaling
  • Diet and metabolism studies
  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • Genetics and Neurodevelopmental Disorders

Their publication record features papers in notable venues, with multiple articles published over time in:

  • Frontiers in Molecular Neuroscience
  • Journal of Biological Chemistry
  • Journal of Neuroscience
  • Scientific Reports
  • Glia

Among recent significant papers by Timmusk are:

  • "CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons," 2020, Journal of Neuroscience
  • "2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience," 2023, Neuron
  • "Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons," 2021, eLife
  • "Revisiting the expression of BDNF and its receptors in mammalian development," 2023, Frontiers in Molecular Neuroscience
  • "Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals," 2022, Scientific Reports

Timmusk frequently collaborates with a number of researchers, including:

  • Jürgen Tuvikene
  • Eli-Eelika Esvald
  • Annela Avarlaid
  • Alex Sirp
  • Annika Rähni

Best Publications

  • Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

    Chiara Zuccato;Andrea Ciammola;Dorotea Rigamonti;Blair R. Leavitt

  • Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.

    Chiara Zuccato;Marzia Tartari;Andrea Crotti;Donato Goffredo

  • Mouse and rat BDNF gene structure and expression revisited

    Tamara Aid;Anna Kazantseva;Marko Piirsoo;Kaia Palm

  • Multiple promoters direct tissue-specific expression of the rat BDNF gene

    Tõnis Timmusk;Tõnis Timmusk;Kaia Palm;Kaia Palm;Madis Metsis;Madis Metsis;Tõnu Reintam

  • Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve

    H Funakoshi;J Frisén;G Barbany;T Timmusk

  • Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.

    M Trupp;M Rydén;H Jörnvall;H Funakoshi

  • Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

    Päivi Lindholm;Merja H. Voutilainen;Juha Laurén;Juha Laurén;Johan Peränen

  • LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia

    Clyde Francks;S. Maegawa;J. Laurén;B. S. Abrahams

  • Neuronal Expression of Zinc Finger Transcription Factor REST/NRSF/XBR Gene

    Kaia Palm;Natale Belluardo;Madis Metsis;Tonis Timmusk;Tonis Timmusk

  • Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues.

    Tõnis Timmusk;Natale Belluardo;Madis Metsis;Håkan Persson

  • Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation

    Madis Metsis;Tonis Timmusk;Ernest Arenas;Hakan Persson

  • Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene.

    Priit Pruunsild;Mari Sepp;Ester Orav;Indrek Koppel

  • CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons

    Eli-Eelika Esvald;Jürgen Tuvikene;Alex Sirp;Sudarshan Patil

  • MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain.

    Päivi Lindholm;Johan Peränen;Jaan-Olle Andressoo;Nisse Kalkkinen

  • A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system.

    Juha Laurén;Matti S Airaksinen;Mart Saarma;Tõnis Timmusk

  • A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.

    Pavel Uvarov;Anastasia Ludwig;Marika Markkanen;Priit Pruunsild

  • Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice

    Nina N. Karpova;Jesse Lindholm;Priit Pruunsild;Tõnis Timmusk

  • Functional Diversity of Human Basic Helix-Loop-Helix Transcription Factor TCF4 Isoforms Generated by Alternative 5′ Exon Usage and Splicing

    Mari Sepp;Kaja Kannike;Ave Eesmaa;Mari Urb

  • Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development

    Kristi Luberg;Jenny Wong;Jenny Wong;Cynthia Shannon Weickert;Cynthia Shannon Weickert;Tõnis Timmusk

  • Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat.

    Kaia Palm;Madis Metsis;Tõnis Timmusk

Frequent Co-Authors

Mart Saarma
Mart Saarma University of Helsinki
Natale Belluardo
Natale Belluardo University of Palermo
Håkan Persson
Håkan Persson Läkemedelsverket
Giuseppa Mudò
Giuseppa Mudò University of Palermo
Matti S. Airaksinen
Matti S. Airaksinen University of Helsinki
Daniele F. Condorelli
Daniele F. Condorelli University of Catania
Dan Lindholm
Dan Lindholm Minerva Foundation
Eero Vasar
Eero Vasar University of Tartu
Carlos F. Ibáñez
Carlos F. Ibáñez Karolinska Institute
Sarah E. Medland
Sarah E. Medland QIMR Berghofer Medical Research Institute

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