World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
18699
World Ranking
4622
National Ranking
156

Overview

Peeyush K. Lala is affiliated with the University of Western Ontario in Canada and has contributed extensively in the fields of medicine, biochemistry, genetics, and molecular biology. The scientist's research primarily focuses on topics related to pregnancy, preeclampsia, and reproductive system studies, alongside investigations in cancer research and disease regulation through molecular mechanisms.

The main topics covered in their work include:

  • Pregnancy and preeclampsia studies
  • Reproductive System and Pregnancy
  • Angiogenesis and VEGF in Cancer
  • Lymphatic System and Diseases
  • Inflammatory mediators and NSAID effects
  • MicroRNA in disease regulation
  • Cancer Risks and Factors

They have published research papers in leading scientific journals with an emphasis on placental biology and cancer-related angiogenesis. Significant recent papers include:

  • A crossroad between placental and tumor biology: What have we learnt? (2021) published in Placenta
  • Prostaglandin E2 Receptor 4 (EP4) as a Therapeutic Target to Impede Breast Cancer-Associated Angiogenesis and Lymphangiogenesis (2021) published in Cancers
  • Decorin production by the human decidua: role in decidual cell maturation (2020) published in Molecular Human Reproduction
  • Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases (2021) published in International Journal of Molecular Sciences
  • Pri-miR526b and Pri-miR655 Are Potential Blood Biomarkers for Breast Cancer (2021) published in Cancers

The scientist frequently collaborates with other researchers. Notable coauthors include:

  • Chidambra Dhariwal Halari
  • Stephen J. Renaud
  • Pinki Nandi
  • Reid Morgan Opperman
  • Mousumi Majumder

Peeyush K. Lala's publications are commonly featured in venues such as Placenta, Cancers, Molecular Human Reproduction, Frontiers in Cell and Developmental Biology, and the International Journal of Molecular Sciences. This distribution reflects an interdisciplinary approach spanning obstetrics and gynecology, molecular biology, immunology, and oncology.

The combination of their research outputs highlights a strong interest in understanding the molecular and cellular processes underlying pregnancy-related conditions and cancer, with a particular focus on angiogenesis, lymphangiogenesis, and inflammatory processes. Their work contributes to expanding knowledge on therapeutic targets and biomarkers involved in these biological systems.

Best Publications

  • Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended Lifespan

    Charles H. Graham;Teresa S. Hawley;Robert C. Hawley;John R. MacDougall

  • Role of nitric oxide in carcinogenesis and tumour progression

    Peeyush K Lala;Chandan Chakraborty

  • Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells.

    Rama Khokha;Paul Waterhouse;Simcha Yagel;Peeyush K. Lala

  • Role of nitric oxide in tumor progression: Lessons from experimental tumors

    Peeyush K. Lala;Amila Orucevic

  • Functional role of cell surface integrins on human trophoblast cell migration : regulation by TGF-beta, IGF-II, and IGFBP-1

    J.A. Irving;P.K. Lala

  • Localization of transforming growth factor-beta at the human fetal-maternal interface: role in trophoblast growth and differentiation.

    Charles H. Graham;Jeffrey J. Lysiak;Keith R. McCrae;Peeyush K. Lala

  • Mechanism of control of trophoblast invasion in situ

    Charles H. Graham;Peeyush K. Lala

  • Human trophoblast stem cell self-renewal and differentiation: Role of decorin

    Pinki Nandi;Hyobin Lim;Eloy Jose Torres-Garcia;Peeyush K. Lala

  • Mechanisms of trophoblast invasiveness and their control: the role of proteases and protease inhibitors.

    Peeyush K. Lala;Charles H. Graham

  • Mechanisms of placental invasion of the uterus and their control.

    Charles H. Graham;Peeyush K. Lala

  • Regulation of human trophoblast migration and invasiveness

    Chandan Chakraborty;Louise M Gleeson;Timothy McKinnon;Peeyush K Lala

  • Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesis.

    Jerry G. Rozic;Chandan Chakraborty;Peeyush K. Lala

  • Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK.

    Timothy McKinnon;Chandan Chakraborty;Louise M. Gleeson;Peter Chidiac

  • Factors regulating trophoblast migration and invasiveness: possible derangements contributing to pre-eclampsia and fetal injury.

    P.K. Lala;C. Chakraborty

  • Insulin-Like Growth Factor-Binding Protein 1 Stimulates Human Trophoblast Migration by Signaling through α5β1 Integrin via Mitogen-Activated Protein Kinase Pathway1

    Louise M. Gleeson;Chandan Chakraborty;Timothy McKinnon;Peeyush K. Lala

  • COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer

    A V Timoshenko;C Chakraborty;G F Wagner;P K Lala

  • CYTOKINETIC ANALYSIS OF TUMOR GROWTH

    Peeyush K. Lala;Harvey M. Patt

  • Autocrine-paracrine regulation of human trophoblast invasiveness by insulin-like growth factor (IGF)-II and IGF-binding protein (IGFBP)-1.

    G.S. Hamilton;J.J. Lysiak;V.K.M. Han;P.K. Lala

  • Nitric oxide promotes murine mammary tumour growth and metastasis by stimulating tumour cell migration, invasiveness and angiogenesis.

    Lorraine C. Jadeski;Kathleen O. Hum;Chandan Chakraborty;Peeyush K. Lala

  • Normal nonmetastatic human trophoblast cells share in vitro invasive properties of malignant cells

    Simcha Yagel;Ranjit S. Parhar;John J. Jeffrey;Peeyush K. Lala;Peeyush K. Lala

Frequent Co-Authors

David T. Denhardt
David T. Denhardt Rutgers, The State University of New Jersey
Robert S. Kerbel
Robert S. Kerbel University of Toronto
Rama Khokha
Rama Khokha Princess Margaret Cancer Centre
James W. Dennis
James W. Dennis Lunenfeld-Tanenbaum Research Institute
William G. Stetler-Stevenson
William G. Stetler-Stevenson National Institutes of Health
Hans-Joachim Gabius
Hans-Joachim Gabius Ludwig-Maximilians-Universität München
Martin L. Breitman
Martin L. Breitman University of Toronto
John J. Jeffrey
John J. Jeffrey Albany Medical Center Hospital
Christopher M. Overall
Christopher M. Overall University of British Columbia
Richard Saffery
Richard Saffery University of Melbourne

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