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Maria Angela Sortino

Maria Angela Sortino

D-Index & Metrics

Neuroscience

D-Index
52
Citations
8071
World Ranking
5395
National Ranking
270

Overview

Maria Angela Sortino is affiliated with the University of Catania in Italy. Their research spans multiple fields including Neuroscience, Medicine, and Biochemistry, Genetics and Molecular Biology, with a particular focus on Neurology and Physiology as prominent subfields.

The scientist's work is frequently published in venues such as Biomolecules, Biochemical Pharmacology, European Journal of Pharmacology, Pharmaceuticals, and the International Journal of Molecular Sciences. These journals reflect their interdisciplinary approach bridging molecular biology and neuropharmacology.

Key topics in their research include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Barrier Structure and Function Studies
  • Neuroscience and Neuropharmacology Research
  • Sirtuins and Resveratrol in Medicine
  • Sphingolipid Metabolism and Signaling
  • Biochemical effects in animals

Frequent coauthors collaborating with Maria Angela Sortino are Sara Merlo, Simona Federica Spampinato, Giuseppe Costantino, Grazia Ilaria Caruso, and Mariangela Chisari. These collaborations represent sustained scientific partnerships contributing to their common fields of study.

Among the recent publications are:

  • "The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs," 2020, Pharmaceuticals
  • "Microglia and the Blood-Brain Barrier: An External Player in Acute and Chronic Neuroinflammatory Conditions," 2023, International Journal of Molecular Sciences
  • "Correction: Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model," 2020, Cell Death and Disease
  • "SIRT1 Mediates Melatonin's Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence," 2020, Biomolecules
  • "SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin," 2021, Biomedicines

Their investigations often center on molecular and cellular mechanisms underlying neuroinflammation, neurodegeneration, and metabolic pathways relevant to Alzheimer's disease and related disorders. This includes detailed studies of microglial activation, blood-brain barrier interactions, and signaling pathways such as those involving sirtuins.

Best Publications

  • Mitotic signaling by β-amyloid causes neuronal death

    A. Copani;F. Condorelli;A. Caruso;C. Vancheri

  • Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

    Agata Copani;Maria Angela Sortino;Ferdinando Nicoletti;Valeria Bruno

  • Effect of rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 on bleomycin-induced lung injury

    T. Genovese;Salvator Cuzzocrea;R. Di Paola;E. Mazzon

  • The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease?

    Andrea Caricasole;Agata Copani;Alessandra Caruso;Filippo Caraci

  • Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain

    G. Casabona;T. Knopfel;R. Kuhn;F. Gasparini

  • Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies β-Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 and mGlu3 Receptors Is Neuroprotective

    Filippo Caraci;Gemma Molinaro;Giuseppe Battaglia;Maria Laura Giuffrida

  • Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

    Filippo Caraci;Simona Federica Spampinato;Maria Grazia Morgese;Fabio Tascedda

  • TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease.

    Filippo Caraci;Giuseppe Battaglia;Valeria Bruno;Paolo Bosco

  • Desensitization of metabotropic glutamate receptors in neuronal cultures

    M. V. Catania;E. Aronica;M. A. Sortino;P. L. Canonico

  • Comparative effects of estradiol benzoate, the antiestrogen clomiphene citrate, and the progestin medroxyprogesterone acetate on kainic acid-induced seizures in male and female rats.

    Ferdinando Nicoletti;Carmela Speciale;Maria Angela Sortino;Gisella Summa

  • Different Expression of TNF- α Receptors and Prostaglandin E2Production in Normal and Fibrotic Lung Fibroblasts

    Carlo Vancheri;Maria Angela Sortino;Valerio Tomaselli;Claudio Mastruzzo

  • Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

    Filippo Caraci;Simona Spampinato;Maria Angela Sortino;Paolo Bosco

  • Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

    Simona Federica Spampinato;Agata Copani;Ferdinando Nicoletti;Maria Angela Sortino

  • Glia Mediates the Neuroprotective Action of Estradiol on β-Amyloid-Induced Neuronal Death

    M. A. Sortino;M. Chisari;S. Merlo;C. Vancheri

  • Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

    Giuseppe Caruso;Claudia G Fresta;Nicolò Musso;Mariaconcetta Giambirtone

  • TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway

    Filippo Caraci;Giuseppe Battaglia;Carla Busceti;Francesca Biagioni

  • DNA Polymerase-β Is Expressed Early in Neurons of Alzheimer's Disease Brain and Is Loaded into DNA Replication Forks in Neurons Challenged with β-Amyloid

    Agata Copani;Jeroen J. M. Hoozemans;Filippo Caraci;Marco Calafiore

  • β-Amyloid-Induced Synthesis of the Ganglioside Gd3 Is a Requisite for Cell Cycle Reactivation and Apoptosis in Neurons

    Agata Copani;Daniela Melchiorri;Andrea Caricasole;Francesca Martini

  • Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

    Filippo Caraci;Giuseppe Battaglia;Maria Angela Sortino;Simona Spampinato

  • Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury

    Tiziana Genovese;Salvatore Cuzzocrea;Rosanna Di Paola;Marco Failla

  • Differential Expression of Estrogen Receptors Alpha and Beta in the Spinal Cord during Postnatal Development: Localization in Glial Cells

    Paola Platania;Floriana Laureanti;Maria Bellomo;Rosario Giuffrida

Frequent Co-Authors

Agata Copani
Agata Copani University of Catania
Pier Luigi Canonico
Pier Luigi Canonico University of Piemonte Orientale
Eleonora Aronica
Eleonora Aronica University of Amsterdam
Thomas Knöpfel
Thomas Knöpfel Hong Kong Baptist University
Luigia Trabace
Luigia Trabace University of Foggia
Giorgio Cruccu
Giorgio Cruccu Sapienza University of Rome

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Related Online Degrees & Career Pathways

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