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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
11734
World Ranking
12054
National Ranking
109

Overview

Karl Lohner is affiliated with the University of Graz in Austria and focuses research on topics within biochemistry, genetics, molecular biology, immunology, and microbiology. Their work intersects various subfields including molecular biology, microbiology, molecular medicine, organic chemistry, and genetics.

The primary research themes covered in their publications include antimicrobial peptides and activities, lipid membrane structure and behavior, antibiotic resistance in bacteria, biochemical and structural characterization, bacterial genetics and biotechnology, immune response and inflammation, as well as enzyme structure and function.

Lohner has contributed to numerous publications in a range of scientific journals. Their frequent publication venues include:

  • Biophysical Journal
  • Biomolecules
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Antimicrobial Agents
  • Applied and Environmental Microbiology

Selected recent papers exemplify the focus on antimicrobial mechanisms and bacterial membrane interactions:

  • Octenidine: Novel insights into the detailed killing mechanism of Gram-negative bacteria at a cellular and molecular level (2020, International Journal of Antimicrobial Agents)
  • Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes (2021, Proceedings of the National Academy of Sciences)
  • Disruption of the Cytoplasmic Membrane Structure and Barrier Function Underlies the Potent Antiseptic Activity of Octenidine in Gram-Positive Bacteria (2022, Applied and Environmental Microbiology)
  • Bridging the Antimicrobial Activity of Two Lactoferricin Derivatives in E. coli and Lipid-Only Membranes (2021, Frontiers in Medical Technology)
  • Where Electrostatics Matter: Bacterial Surface Neutralization and Membrane Disruption by Antimicrobial Peptides SAAP-148 and OP-145 (2022, Biomolecules)

Frequent coauthors collaborating with Lohner include:

  • Georg Pabst
  • Lisa Marx
  • Enrico F. Semeraro
  • Nermina Malanović
  • Johannes Mandl

This collaborative network reflects interdisciplinary approaches combining biophysical, biochemical, and microbiological perspectives to address bacterial membrane function and antimicrobial resistance.

Best Publications

  • Detergent-like actions of linear amphipathic cationic antimicrobial peptides.

    Burkhard Bechinger;Karl Lohner

  • The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

    Anna de Breij;Martijn Riool;Robert A. Cordfunke;Nermina Malanovic

  • Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs.

    Sabrina Riedl;Dagmar Zweytick;Karl Lohner

  • Differential scanning calorimetry and X-ray diffraction studies of the specificity of the interaction of antimicrobial peptides with membrane-mimetic systems.

    Karl Lohner;Elmar J. Prenner

  • In search of a novel target - phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy.

    Sabrina Riedl;Beate Rinner;Martin Asslaber;Helmut Schaider

  • Mechanism of the Lamellar/Inverse Hexagonal Phase Transition Examined by High Resolution X-Ray Diffraction

    Michael Rappolt;Andrea Hickel;Frank Bringezu;Karl Lohner

  • New strategies for novel antibiotics: peptides targeting bacterial cell membranes.

    Karl Lohner

  • Structural analysis of weakly ordered membrane stacks

    Georg Pabst;Richard Koschuch;Beatriz Pozo-Navas;Michael Rappolt

  • Structural and Biochemical Properties of Lipid Particles from the Yeast Saccharomyces cerevisiae

    Tibor Czabany;Andrea Wagner;Dagmar Zweytick;Karl Lohner

  • Structure and thermodynamics of the dihexadecylphosphatidylcholine-water system.

    Peter Laggner;Karl Lohner;Gábor Degovics;Karl Müller

  • Composition dependence of vesicle morphology and mixing properties in a bacterial model membrane system

    B. Pozo Navas;K. Lohner;G. Deutsch;E. Sevcsik

  • Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems.

    Karl Lohner;Angelika Latal;Robert I. Lehrer;Tomas Ganz

  • Structural aspects of the interaction of peptidyl-glycylleucine-carboxyamide, a highly potent antimicrobial peptide from frog skin, with lipids.

    Angelika Latal;Gabor Degovics;Raquel F. Epand;Richard M. Epand

  • Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

    Jörg Andrä;Karl Lohner;Sylvie E. Blondelle;Roman Jerala

  • Self-regulation of the lipid content of membranes by non-bilayer lipids: a hypothesis

    Győző Garab;Karl Lohner;Peter Laggner;Tibor Farkas

  • Stabilization of non-bilayer structures by the etherlipid ethanolamine plasmalogen.

    Karl Lohner;Pavel Balgavy;Albin Hermetter;Fritz Paltauf

  • Interaction of LL-37 with Model Membrane Systems of Different Complexity: Influence of the Lipid Matrix

    E. Sevcsik;G. Pabst;W. Richter;S. Danner

  • Phase behavior of ethanolamine plasmalogen

    K. Lohner;A. Hermetter;F. Paltauf

  • How lipids influence the mode of action of membrane-active peptides.

    E. Sevcsik;G. Pabst;A. Jilek;K. Lohner

  • Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity.

    Patrick Garidel;Michael Rappolt;Andra B. Schromm;Jörg Howe

Frequent Co-Authors

Peter Laggner
Peter Laggner Austrian Academy of Sciences
Roman Jerala
Roman Jerala National Institute of Chemistry
Ignacio Moriyón
Ignacio Moriyón University of Navarra
Albin Hermetter
Albin Hermetter Graz University of Technology
Günther Daum
Günther Daum Graz University of Technology
Ruthven N.A.H. Lewis
Ruthven N.A.H. Lewis University of Alberta
Vito Turk
Vito Turk Jožef Stefan Institute
Klaus Brandenburg
Klaus Brandenburg Leibniz Institute for Neurobiology
Fritz Paltauf
Fritz Paltauf Graz University of Technology
Heinz Amenitsch
Heinz Amenitsch Graz University of Technology

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