Josephine Lai

Best Publications

• Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

  Claes R Wahlestedt;Peter Salmi;Liam Good;Johanna Kela

  894
  Citations

• CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.

  Mohab M. Ibrahim;Frank Porreca;Josephine Lai;Phillip J. Albrecht

  666
  Citations

• Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

  Mohab M. Ibrahim;Hongfeng Deng;Alexander Zvonok;Debra A. Cockayne

  613
  Citations

• Unmasking the tonic-aversive state in neuropathic pain.

  Tamara King;Louis Vera-Portocarrero;Tannia Gutierrez;Todd W Vanderah

  603
  Citations

• Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.

  Josephine Lai;Michael S Gold;Chang Sook Kim;Di Bian

  589
  Citations

• A Comparison of the Potential Role of the Tetrodotoxin-Insensitive Sodium Channels, PN3/SNS and NaN/SNS2, in Rat Models of Chronic Pain

  Frank Porreca;Josephine Lai;D. I. Bian;Sandra Wegert

  490
  Citations

• Redistribution of NaV1.8 in Uninjured Axons Enables Neuropathic Pain

  Michael S. Gold;Daniel Weinreich;Chang Sook Kim;Ruizhong Wang

  466
  Citations

• Distinct potassium channels on pain-sensing neurons

  Matthew N. Rasband;Eunice W. Park;Todd W. Vanderah;Josephine Lai

  432
  Citations

• Voltage-Gated Sodium Channels and Hyperalgesia

  Josephine Lai;Frank Porreca;John C. Hunter;Michael S. Gold

  429
  Citations

• Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance

  Todd W. Vanderah;Luis R. Gardell;Shannon E. Burgess;Mohab Ibrahim

  411
  Citations

• Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.

  Shannon E. Burgess;Luis R. Gardell;Michael H. Ossipov;T. Philip Malan

  403
  Citations

• Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance

  Todd W. Vanderah;Nova M. H. Suenaga;Michael H. Ossipov;T. Philip Malan

  390
  Citations

• Spinal and Supraspinal Mechanisms of Neuropathic Pain

  Michael H. Ossipov;Josephine Lai;T. Philip Malan;Frank Porreca

  371
  Citations

• Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin.

  Todd W. Vanderah;Michael H. Ossipov;Josephine Lai;T.Philip Malan

  369
  Citations

• Pronociceptive actions of dynorphin maintain chronic neuropathic pain.

  Zaijie Wang;Luis R. Gardell;Michael H. Ossipov;Todd W. Vanderah

  361
  Citations

• Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats.

  Michael H. Ossipov;Di Bian;T.Philip Malan;Josephine Lai

  319
  Citations

• Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers.

  Luis R. Gardell;Ruizhong Wang;Shannon E. Burgess;Michael H. Ossipov

  316
  Citations

• Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure.

  Michael H. Ossipov;Josephine Lai;Tamara King;Todd W. Vanderah

  311
  Citations

• The role of voltage-gated sodium channels in neuropathic pain.

  Josephine Lai;John C Hunter;Frank Porreca

  308
  Citations

• Inhibition of Neuropathic Pain by Selective Ablation of Brainstem Medullary Cells Expressing the μ-Opioid Receptor

  Frank Porreca;Shannon E. Burgess;Luis R. Gardell;Todd W. Vanderah

  302
  Citations