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Chemistry

D-Index
41
Citations
9919
World Ranking
17662
National Ranking
4311

Overview

John W. Huffman was affiliated with Clemson University in the United States. Their research primarily focused on biochemistry, genetics, and molecular biology, with significant contributions to neuroscience. The main subfields of their study included molecular biology, cellular and molecular neuroscience, and pharmacology.

The research topics John W. Huffman explored covered pharmacological receptor mechanisms and effects, cannabis and cannabinoid research, neurotransmitter receptor influence on behavior, receptor mechanisms and signaling, and neuropeptides and animal physiology.

The scientist published several papers over recent years. Among these were:

  • The Spicy Story of Cannabimimetic Indoles, 2021, published in Molecules
  • Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors, 2023, European Journal of Medicinal Chemistry
  • Design, Synthesis, and Evaluation of Substituted Alkylindoles that Activate G Protein-Coupled Receptors Distinct from the Cannabinoid Cb1 and Cb2 Receptors, 2023, SSRN Electronic Journal
  • Correction: Howlett et al. The Spicy Story of Cannabimimetic Indoles. Molecules 2021, 26, 6190, 2024, Molecules
  • 101 - Older Age is Associated with Persistent Urinary Incontinence After Sling, 2025, Continence

John W. Huffman collaborated frequently with several coauthors, including:

  • Adllyn C. Howlett
  • Brian F. Thomas
  • Toni Kline
  • Faith R. Kreitzer
  • Dow P. Hurst

Their work appeared repeatedly in notable publication venues such as Molecules, European Journal of Medicinal Chemistry, SSRN Electronic Journal, and Continence.

Best Publications

  • Cannabinoids control spasticity and tremor in a multiple sclerosis model.

    D Baker;G Pryce;J L Croxford;P Brown

  • Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor

    Cristina Sánchez;María L. de Ceballos;Teresa Gómez del Pulgar;Daniel Rueda

  • Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors

    M. Llanos Casanova;Cristina Blázquez;Jesús Martínez-Palacio;Concepción Villanueva

  • Inhibition of tumor angiogenesis by cannabinoids

    Cristina Blázquez;M. Llanos Casanova;Anna Planas;Teresa Gómez del Pulgar

  • Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

    John W. Huffman;Gulay Zengin;Ming-Jung Wu;Jianzhong Lu

  • Design, synthesis and pharmacology of cannabimimetic indoles

    John W. Huffman;Dong Dai;Billy R. Martin;David R. Compton

  • 3-(1′,1′-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor

    John W. Huffman;John Liddle;Shu Yu;Mie Mie Aung

  • Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding

    Mie Mie Aung;Graeme Griffin;John W Huffman;Ming-Jung Wu

  • JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist

    Brady K Atwood;Brady K Atwood;John Huffman;Alex Straiker;Ken Mackie

  • Structure-activity relationships of indole- and pyrrole-derived cannabinoids.

    Jenny L. Wiley;David R. Compton;Dong Dai;Julia A. H. Lainton

  • Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury

    Sándor Bátkai;Douglas Osei-Hyiaman;Hao Pan;Osama El-Assal

  • CB2-receptor stimulation attenuates TNF-α-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion

    Mohanraj Rajesh;Partha Mukhopadhyay;Sandor Batkai;Gyorgy Hasko

  • Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes

    J W Huffman;L W Padgett

  • Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals.

    Graeme Griffin;Susanthi R. Fernando;Ruth A. Ross;Neil G. McKay

  • Synthesis and Pharmacology of a Very Potent Cannabinoid Lacking a Phenolic Hydroxyl with High Affinity for the CB2 Receptor

    John W. Huffman;Shen Yu;Vincent Showalter;Mary E. Abood

  • Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids.

    Jenny L. Wiley;Julie A. Marusich;John W. Huffman

  • 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles.

    John W. Huffman;Paul V. Szklennik;Amanda Almond;Kristen Bushell

  • 3-Indolyl-1-naphthylmethanes: New Cannabimimetic Indoles. Provide Evidence for Aromatic Stacking Interactions with the. CB1 Cannabinoid Receptor

    John W. Huffman;Ross Mabon;Ming-Jung Wu;Jianzhong Lu

  • CB2 cannabinoid receptor agonists attenuate TNF-α-induced human vascular smooth muscle cell proliferation and migration

    M Rajesh;P Mukhopadhyay;G Haskó;J W Huffman

  • Cannabimimetic indoles, pyrroles and indenes.

    Huffman Jw

  • 1-ALKYL-3-(1-NAPHTHOYL)PYRROLES : A NEW CLASS OF CANNABINOID

    Julia A.H. Lainton;John W. Huffman;Billy R. Martin;David R. Compton

  • DIFFERENTIAL BLOCKADE OF THE ANTINOCICEPTIVE EFFECTS OF CENTRALLY ADMINISTERED CANNABINOIDS BY SR141716A

    Sandra P. Welch;John W. Huffman;John Lowe

Frequent Co-Authors

Billy R. Martin
Billy R. Martin Virginia Commonwealth University
Jenny L. Wiley
Jenny L. Wiley Research Triangle Park Foundation
Jenny L. Wiley
Jenny L. Wiley RTI International
William T. Pennington
William T. Pennington Clemson University
Pal Pacher
Pal Pacher National Institutes of Health
Ken Mackie
Ken Mackie Indiana University
Sandor Batkai
Sandor Batkai Cardior Pharmaceuticals
Melanie M. Cooper
Melanie M. Cooper Michigan State University
György Haskó
György Haskó Columbia University
Raj K. Razdan
Raj K. Razdan Organix (United States)

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