John S. O'Brien

Overview

Best Publications

• Lipid composition of the normal human brain: gray matter, white matter, and myelin

  John S. O'Brien;E. Lois Sampson

  1007
  Citations

• Tay-Sachs Disease: Generalized Absence of a Beta-D-N-Acetylhexosaminidase Component

  Shintaro Okada;John S. O'Brien

  926
  Citations

• Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin

  John S. O'Brien;E. Lois Sampson

  639
  Citations

• Tay-sachs disease. Detection of heterozygotes and homozygotes by serum hexosaminidase assay.

  John S. O'Brien;Shintaro Okada;Agnes Chen;Dorothy L. Fillerup

  564
  Citations

• Generalized Gangliosidosis: Beta-Galactosidase Deficiency

  Shintaro Okada;John S. O'Brien

  532
  Citations

• Saposin proteins: structure, function, and role in human lysosomal storage disorders.

  John S. O'Brien;Yasuo Kishimoto

  473
  Citations

• Saposins: structure, function, distribution, and molecular genetics.

  Y Kishimoto;M Hiraiwa;J S O'Brien

  463
  Citations

• Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus

  John S. O'Brien;Keith A. Kretz;Nazneen Dewji;David A. Wenger

  342
  Citations

• Gaucher's disease: deficiency of 'acid' -glucosidase and reconstitution of enzyme activity in vitro.

  Mae Wan Ho;John S. O'Brien

  322
  Citations

• Identification of prosaposin as a neurotrophic factor

  John S. O'Brien;Geoffrey S. Carson;Hee Chan Seo;Masao Hiraiwa

  317
  Citations

• Stability of the Myelin Membrane

  John S. O'Brien

  309
  Citations

• I-Cell Disease: Biochemical Studies

  Jules G Leroy;Mae Wan Ho;Monica C Macbrinn;Klaus Zielke

  272
  Citations

• Cell membranes—Composition: Structure: Function

  John S. O'Brien

  241
  Citations

• Cloning and expression of human arylsulfatase A.

  C. Stein;V. Gieselmann;J. Kreysing;B. Schmidt

  223
  Citations

• Quantification and fatty acid and fatty aldehyde composition of ethanolamine, choline, and serine glycerophosphatides in human cerebral grey and white matter

  John S. O'Brien;John S. O'Brien;Dorothy L. Fillerup;Dorothy L. Fillerup;James F. Mead;James F. Mead

  217
  Citations

• GENERALIZED GANGLIOSIDOSIS: ANOTHER INBORN ERROR OF GANGLIOSIDE METABOLISM?

  John S. O'brien;Maury B. Stern;Benjamin H. Landing;Joanne K. O'brien

  214
  Citations

• Gm1 Ganglioside β-Galactosidase A PURIFICATION AND STUDIES OF THE ENZYME FROM HUMAN LIVER

  Anthony G.W. Norden;Linda L. Tennant;John S. O'Brien

  207
  Citations

• Sanfilippo Syndrome: Profound Deficiency of Alpha-Acetylglucosaminidase Activity in Organs and Skin Fibroblasts from Type-B Patients

  John S. O'brien

  201
  Citations

• Tay-Sachs Disease: Prenatal Diagnosis

  John S. O'Brien;Shintaro Okada;Dorothy L. Fillerup;M. Lois Veath

  197
  Citations

• Synthesis of 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid and detection of skin fibroblast neuraminidase in normal humans and in sialidosis.

  Thomas G. Warner;John S. O'Brien

  190
  Citations