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Jean-Pierre Mothet

Jean-Pierre Mothet

D-Index & Metrics

Neuroscience

D-Index
35
Citations
8759
World Ranking
9110
National Ranking
443

Research.com Recognitions

  • 2020 - Member of Academia Europaea

Overview

Jean-Pierre Mothet is affiliated with Aix-Marseille University in France. Their research primarily focuses on the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with particular attention to subfields such as Cellular and Molecular Neuroscience, Biochemistry, Molecular Biology, Neurology, and Physiology.

The scientist's main topics of study include Amino Acid Enzymes and Metabolism, Neuroscience and Neuropharmacology Research, Epigenetics and DNA Methylation, Diet and metabolism studies, Receptor Mechanisms and Signaling, Neurotransmitter Receptor Influence on Behavior, and Vagus Nerve Stimulation Research.

Jean-Pierre Mothet's recent publications cover a range of topics within molecular neuroscience and neuropharmacology. Selected papers include:

  • "d-Amino acids: new clinical pathways for brain diseases" (2023, Trends in Molecular Medicine)
  • "Dysfunctional d-aspartate metabolism in BTBR mouse model of idiopathic autism" (2020, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics)
  • "Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d -serine" (2021, Proceedings of the National Academy of Sciences)
  • "Disruption of Astrocyte-Dependent Dopamine Control in the Developing Medial Prefrontal Cortex Leads to Excessive Grooming in Mice" (2022, Biological Psychiatry)
  • "Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism" (2020, Scientific Reports)

Frequent co-authors collaborating with Jean-Pierre Mothet include Glenn Dallérac, Isis Nem de Oliveira Souza, Francesco Petrelli, Tamara Zehnder, and Corrado Calì. These collaborations have contributed to a consistent publication record in several venues.

The scientist's work is often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biological Psychiatry, Trends in Molecular Medicine, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, and Proceedings of the National Academy of Sciences.

In recognition of their contributions, Jean-Pierre Mothet was named a Member of the Academia Europaea in 2020.

Best Publications

  • d-Serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor

    Jean Pierre Mothet;Angèle T. Parent;Angèle T. Parent;Herman Wolosker;Roscoe O. Brady

  • Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory

    Aude Panatier;Dionysia T. Theodosis;Jean-Pierre Mothet;Bastien Touquet

  • Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

    Thomas Papouin;Laurent Ladépêche;Laurent Ladépêche;Jérôme Ruel;Jérôme Ruel;Silvia Sacchi

  • Purification of serine racemase: Biosynthesis of the neuromodulator d-serine

    Herman Wolosker;Kevin N. Sheth;Masaaki Takahashi;Jean Pierre Mothet

  • Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine

    Jean-Pierre Mothet;Loredano Pollegioni;Gilles Ouanounou;Magalie Martineau

  • Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion.

    Alexei Verkhratsky;Michela Matteoli;Vladimir Parpura;Jean Pierre Mothet

  • Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.

    Brigitte Potier;Fabrice R Turpin;Pierre-Marie Sinet;Emilie Rouaud

  • Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex

    Pascal Fossat;Pascal Fossat;Fabrice R. Turpin;Fabrice R. Turpin;Silvia Sacchi;Jérôme Dulong;Jérôme Dulong

  • A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory.

    J. P. Mothet;E. Rouaud;P.-M. Sinet;B. Potier

  • Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.

    Magalie Martineau;Ting Shi;Julien Puyal;Ann M. Knolhoff

  • D-serine signalling in the brain: friend and foe.

    Magalie Martineau;Gérard Baux;Jean-Pierre Mothet

  • Regulation of N-methyl-d-aspartate receptors by astrocytic d-serine

    S.H.R. Oliet;J.-P. Mothet

  • PLG72 Modulates Intracellular D-Serine Levels through Its Interaction with D-Amino Acid Oxidase : EFFECT ON SCHIZOPHRENIA SUSCEPTIBILITY

    Silvia Sacchi;Mariagrazia Bernasconi;Magalie Martineau;Jean-Pierre Mothet

  • Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes.

    Verónica Abudara;Lisa Roux;Glenn Dallérac;Isabelle Matias;Isabelle Matias

  • Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.

    Francesco Petrelli;Glenn Dallérac;Luca Pucci;Corrado Calì;Corrado Calì

  • Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus

    Matildé Le Bail;Magalie Martineau;Silvia Sacchi;Natalia Yatsenko

  • Confocal imaging and tracking of the exocytotic routes for D‐serine‐mediated gliotransmission

    Magalie Martineau;Thierry Galli;Gérard Baux;Jean-Pierre Mothet;Jean-Pierre Mothet

  • Cyclic ADP-ribose and calcium-induced calcium release regulate neurotransmitter release at a cholinergic synapse of Aplysia

    Jean-Pierre Mothet;Philippe Fossier;François-Marie Meunier;Jacques Stinnakre

  • Cell-type specific mechanisms of D-serine uptake and release in the brain

    Magalie Martineau;Vladimir Parpura;Vladimir Parpura;Jean-Pierre Mothet

  • Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses

    Joana S Ferreira;Joana S Ferreira;Thomas Papouin;Laurent Ladépêche;Laurent Ladépêche;Andrea Yao

  • Reduced serine racemase expression contributes to age-related deficits in hippocampal cognitive function.

    F.R. Turpin;F.R. Turpin;F.R. Turpin;B. Potier;J.R. Dulong;J.R. Dulong;P.-M. Sinet

Frequent Co-Authors

Bruno Giros
Bruno Giros McGill University
Patrick Dutar
Patrick Dutar University of Paris-Saclay
Laurent Groc
Laurent Groc University of Bordeaux
Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
Joseph T. Coyle
Joseph T. Coyle Harvard University
Robert H. Edwards
Robert H. Edwards University of California, San Francisco
Bruno Cauli
Bruno Cauli Sorbonne University
Frank Kirchhoff
Frank Kirchhoff University of Ulm

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