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Biology and Biochemistry

D-Index
62
Citations
16271
World Ranking
10657
National Ranking
4632

Overview

Hazel H. Szeto is affiliated with Cornell University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Subfields of their work include Molecular Biology, Physiology, Orthopedics and Sports Medicine, Surgery, and Pathology and Forensic Medicine.

The scientific topics addressed in their publications focus notably on mitochondrial function and pathology, ATP synthase and ATPases research, RNA and protein synthesis mechanisms, tendon structure and treatment, adipose tissue and metabolism, sports injuries and prevention, and shoulder injury and treatment.

Hazel H. Szeto has contributed to several recent papers, including: "Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice" (2020, eLife), "The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action" (2020, Journal of Biological Chemistry), "Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte" (2020, eLife), "Targeting Mitochondria by SS-31 Ameliorates the Whole Body Energy Status in Cancer- and Chemotherapy-Induced Cachexia" (2021, Cancers), and "APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis" (2021, Human Molecular Genetics).

Frequent coauthors in Szeto's research include Nathan N. Alder, David J. Marcinek, Peter S. Rabinovitch, Emery L. Ng, and Shaoyi Liu. These collaborations have contributed to advancements in the understanding of mitochondrial biology and related health conditions.

Their work has been published across various scientific venues. Common publication outlets feature eLife, bioRxiv (Cold Spring Harbor Laboratory), Journal of the American Society of Nephrology, Biophysical Journal, and Orthopaedic Journal of Sports Medicine.

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

  • Molecular Biology
  • Physiology
  • Orthopedics and Sports Medicine
  • Surgery
  • Pathology and Forensic Medicine

  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • RNA and protein synthesis mechanisms
  • Tendon Structure and Treatment
  • Adipose Tissue and Metabolism
  • Sports injuries and prevention
  • Shoulder Injury and Treatment

  • Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice (2020, eLife)
  • The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action (2020, Journal of Biological Chemistry)
  • Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte (2020, eLife)
  • Targeting Mitochondria by SS-31 Ameliorates the Whole Body Energy Status in Cancer- and Chemotherapy-Induced Cachexia (2021, Cancers)
  • APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis (2021, Human Molecular Genetics)

  • Nathan N. Alder
  • David J. Marcinek
  • Peter S. Rabinovitch
  • Emery L. Ng
  • Shaoyi Liu

  • eLife
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the American Society of Nephrology
  • Biophysical Journal
  • Orthopaedic Journal of Sports Medicine

Best Publications

  • Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

    Ethan J. Anderson;Mary E. Lustig;Kristen E. Boyle;Tracey L. Woodlief

  • A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia

    Ivone Gomes;Achla Gupta;Julija Filipovska;Hazel H. Szeto

  • Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer

    Hazel H. Szeto;Charles E. Inturrisi;Raymond Houde;Stuart Saal

  • Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy

    Dao Fu Dai;Tony Chen;Hazel Szeto;Madeline Nieves-Cintrón

  • Protection of mitochondria prevents high-fat diet-induced glomerulopathy and proximal tubular injury.

    Hazel H. Szeto;Shaoyi Liu;Yi Soong;Nazia Alam

  • Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

    Lichuan Yang;Kesheng Zhao;Noel Y. Calingasan;Guoxiong Luo

  • Potent mitochondria-targeted peptides reduce myocardial infarction in rats.

    Janghyun Cho;Kyungheon Won;DunLi Wu;Yi Soong

  • Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD.

    Hazel H. Szeto

  • Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

    Hazel H. Szeto;Peter W. Schiller

  • Mitochondrial‐targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

    Michael P. Siegel;Shane E. Kruse;Justin M. Percival;Jorming Goh

  • Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis.

    Susanne Petri;Mahmoud Kiaei;Maria Damiano;Andrew Hiller

  • Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD.

    Hazel H. Szeto;Shaoyi Liu;Yi Soong;Surya V. Seshan

  • Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant.

    Erin E. Talbert;Ashley J. Smuder;Kisuk Min;Oh Sung Kwon

  • Prenatal Development of Sleep-Wake Patterns in Sheep

    Hazel H. Szeto;Donald J. Hinman

  • Global Proteomics and Pathway Analysis of Pressure-overload Induced Heart Failure and Its Attenuation by Mitochondrial Targeted Peptides

    Dao Fu Dai;Edward J. Hsieh;Tony Chen;Lorena G. Menendez

  • Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy.

    Kisuk Min;Oh-Sung Kwon;Ashley J. Smuder;Michael P. Wiggs

  • Development of mitochondria-targeted aromatic-cationic peptides for neurodegenerative diseases.

    Hazel H. Szeto

  • Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis

    Shaoyi Liu;Yi Soong;Surya V. Seshan;Hazel H. Szeto

  • Fluorescent dyes alter intracellular targeting and function of cell-penetrating tetrapeptides

    Hazel H. Szeto;Peter W. Schiller;Kesheng Zhao;Guoxiong Luo

  • In vivo pharmacokinetics of selective mu-opioid peptide agonists.

    Hazel H. Szeto;Jerry L. Lovelace;Genevieve Fridland;Yi Soong

Frequent Co-Authors

Peter S. Rabinovitch
Peter S. Rabinovitch University of Washington
Peter W. Schiller
Peter W. Schiller University of Montreal
Scott K. Powers
Scott K. Powers University of Florida
Maurice Manning
Maurice Manning University of Toledo
Laurence G. Rahme
Laurence G. Rahme Harvard University
Michael J. MacCoss
Michael J. MacCoss University of Washington
Ronald G. Tompkins
Ronald G. Tompkins Harvard University
Edward J. Dubovi
Edward J. Dubovi Cornell University
Michael M. Myers
Michael M. Myers Columbia University
Hugh D. Robertson
Hugh D. Robertson Cornell University

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