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Biology and Biochemistry

D-Index
70
Citations
20587
World Ranking
6926
National Ranking
506

Overview

Dieter Marmé is affiliated with the University of Freiburg in Germany. Their research primarily focuses on the intersection of biochemistry, genetics, and molecular biology, with specific emphasis on molecular biology, cancer research, genetics, and oncology.

Their work explores key topics in cancer biology, including:

  • Angiogenesis and VEGF in Cancer
  • Cancer, Hypoxia, and Metabolism
  • Virus-based gene therapy research
  • Cancer Cells and Metastasis

Marmé has contributed to scientific literature through publications in journals such as Cancers and bioRxiv (Cold Spring Harbor Laboratory). Their recent papers include:

  • Regression of Human Breast Carcinoma in Nude Mice after Adsflt Gene Therapy Is Mediated by Tumor Vascular Endothelial Cell Apoptosis, 2022, Cancers
  • Regression of Human Breast Carcinoma in Nude Mice After Adsflt Gene Therapy is Mediated by Tumor Vascular Endothelial Cell Apoptosis, 2020, bioRxiv (Cold Spring Harbor Laboratory)

The scope of these studies centers on the use of gene therapy approaches targeting tumor vascular endothelial cells to induce apoptosis, relevant to breast carcinoma models in mice.

Collaborations have involved several frequent co-authors that appear across multiple publications, including:

  • Angelina Felici
  • Donald P. Bottaro
  • Antonella Mangoni
  • Petra Reusch
  • Imre Kovesdi

These collaborative efforts indicate a multidisciplinary approach to cancer research and gene therapy, combining expertise in molecular mechanisms with translational models.

Best Publications

  • Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

    G Martiny-Baron;M G Kazanietz;H Mischak;P M Blumberg

  • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

    Bernhard Barleon;Silvano Sozzani;Dan Zhou;Herbert A. Weich

  • Protein kinase C alpha activates RAF-1 by direct phosphorylation

    Walter Kolch;Gisela Heidecker;Georg Kochs;Richard Hummel

  • Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological Response of PTK787/ZK 222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, in Patients With Advanced Colorectal Cancer and Liver Metastases: Results From Two Phase I Studies

    Bruno Morgan;Anne L. Thomas;Joachim Drevs;Juergen Hennig

  • Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

    A Kieser;H A Weich;G Brandner;D Marmé

  • Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease

    Andrea Kraft;Karin Weindel;Andreas Ochs;Christian Marth

  • Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

    Stefan Grugel;Günter Finkenzeller;Karin Weindel;Bernhard Barleon

  • Effects of PTK787/ZK 222584, a Specific Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, on Primary Tumor, Metastasis, Vessel Density, and Blood Flow in a Murine Renal Cell Carcinoma Model

    Joachim Drevs;Inga Hofmann;Harald Hugenschmidt;Christine Wittig

  • Reversion of Deregulated Expression of Vascular Endothelial Growth Factor in Human Renal Carcinoma Cells by von Hippel-Lindau Tumor Suppressor Protein

    Gerhard Siemeister;Karin Weindel;Katja Mohrs;Bernhard Barleon

  • Human Chorionic Gonadotropin-Dependent Expression of Vascular Endothelial Growth Factor/Vascular Permeability Factor in Human Granulosa Cells: Importance in Ovarian Hyperstimulation Syndrome*

    J. Neulen;Zhaoping Yan;S. Raczek;K. Weindel

  • Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis.

    Sundeept Ballara;Peter C. Taylor;Petra Reusch;Dieter Marmé

  • Oncogenes as inducers of tumor angiogenesis

    J. Rak;J. Filmus;J. Filmus;G. Finkenzeller;S. Grugel

  • Molecular mechanisms of anti-angiogenic effect of curcumin.

    Anupama Edward Gururaj;Madesh Belakavadi;Deepak A. Venkatesh;Dieter Marmé

  • Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells.

    Bernhard Barleon;Gerhard Siemeister;Georg Martiny-Baron;Karin Weindel

  • Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1

    Bernhard Barleon;Frank Totzke;Christel Herzog;Stephen Blanke

  • Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

    Günter Finkenzeller;Angelica Sparacio;Antje Technau;Dieter Marmé

  • Two independent mechanisms essential for tumor angiogenesis : Inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway

    Gerhard Siemeister;Michael Schirner;Karin Weindel;Petra Reusch

  • Angiopoietin-1 and Angiopoietin-2 Share the Same Binding Domains in the Tie-2 Receptor Involving the First Ig-like Loop and the Epidermal Growth Factor-like Repeats

    Ulrike Fiedler;Tanja Krissl;Stefanie Koidl;Cornelia Weiss

  • PTK787/ZK 222584, a Specific Vascular Endothelial Growth Factor-Receptor Tyrosine Kinase Inhibitor, Affects the Anatomy of the Tumor Vascular Bed and the Functional Vascular Properties as Detected by Dynamic Enhanced Magnetic Resonance Imaging

    Joachim Drevs;Ralph Müller-Driver;Christine Wittig;Stefan Fuxius

  • Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: the key to angiogenesis?

    Karin Weindel;Jean Richard Moringlane;Dieter Marmé;Herbert A. Weich

Frequent Co-Authors

Eberhard Schäfer
Eberhard Schäfer University of Freiburg
Georg Kochs
Georg Kochs University of Freiburg
Jörg Wilting
Jörg Wilting University of Göttingen
Bodo Christ
Bodo Christ University of Freiburg
Hellmut G. Augustin
Hellmut G. Augustin Heidelberg University
Walter Kolch
Walter Kolch University College Dublin
Friedhelm Beyersdorf
Friedhelm Beyersdorf University of Freiburg
William P. Steward
William P. Steward University of Leicester
Hubert Greppin
Hubert Greppin University of Geneva
marius ueffing
marius ueffing University of Tübingen

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