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Biology and Biochemistry

D-Index
48
Citations
11003
World Ranking
18268
National Ranking
7465

Overview

Deborah A. O'Brien is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research contributions span the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Specifically, their work touches on several subfields, including Molecular Biology, Reproductive Medicine, Public Health, Environmental and Occupational Health, Genetics, and Insect Science.

The scientist has focused on a range of topics linked primarily to reproductive biology and genetics. Notable research themes include:

  • Sperm and Testicular Function
  • Reproductive Biology and Fertility
  • Animal Genetics and Reproduction
  • Genomic Variations and Chromosomal Abnormalities
  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Viral Infectious Diseases and Gene Expression in Insects

O'Brien's recent publications reflect these interests and were primarily published through UNC Libraries. Selected works include:

  • Metabolic Substrates Exhibit Differential Effects on Functional Parameters of Mouse Sperm Capacitation, 2020, UNC Libraries
  • A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2, 2020, UNC Libraries
  • Classification of Mouse Sperm Motility Patterns Using an Automated Multiclass Support Vector Machines Model, 2020, UNC Libraries
  • Recombinant human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) is expressed at high yield as an active homotetramer in baculovirus-infected insect cells, 2020, UNC Libraries
  • The Founder Strains of the Collaborative Cross Express a Complex Combination of Advantageous and Deleterious Traits for Male Reproduction, 2020, UNC Libraries

Frequent collaborators in O'Brien's research include Summer G. Goodson, Polina V. Danshina, Timothy A. Bell, David L. Aylor, and Leonard McMillan. These coauthors have collaborated on multiple projects, contributing to the overall scope of the scientist's research output.

Most of O'Brien's scholarly activity has been disseminated via UNC Libraries, which accounts for the majority of their publications. The research engages deeply with genetic and molecular aspects of reproductive biology, integrating computational modeling, molecular techniques, and genetic analysis to advance understanding of sperm function and reproductive traits.

Best Publications

  • Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterization.

    AR Bellve;JC Cavicchia;CF Millette;DA O'Brien

  • Male–female differences in fertility and blood pressure in ACE-deficient mice

    J. H. Krege;S. W. M. John;L. L. Langenbach;J. B. Hodgin

  • The genome architecture of the collaborative cross mouse genetic reference population

    Fuad A. Iraqi;Mustafa Mahajne;Yasser Salaymah;Hani Sandovski

  • GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE-S, A SPERM-SPECIFIC GLYCOLYTIC ENZYME, IS REQUIRED FOR SPERM MOTILITY AND MALE FERTILITY

    Kiyoshi Miki;Weidong Qu;Weidong Qu;Eugenia H. Goulding;William D. Willis

  • Fibrous sheath of mammalian spermatozoa.

    Edward M. Eddy;Kiyotaka Toshimori;Deborah A. O'Brien

  • Dissociation of the mouse testis and characterization of isolated spermatogenic cells.

    A R Bellvé;C F Millette;Y M Bhatnagar;D A O'Brien

  • Angiotensin-converting enzyme and male fertility

    John R. Hagaman;Jeffrey S. Moyer;Eric S. Bachman;Mathilde Sibony

  • Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity

    David S. Franklin;Virginia L. Godfrey;Deborah A. O'Brien;Chuxia Deng

  • Phosphoglycerate Kinase 2 (PGK2) Is Essential for Sperm Function and Male Fertility in Mice

    Polina V. Danshina;Christopher B. Geyer;Qunsheng Dai;Eugenia H. Goulding

  • Gene expression during mammalian meiosis.

    E.M. Eddy;Deborah A. O'Brien

  • Multiple Glycolytic Enzymes Are Tightly Bound to the Fibrous Sheath of Mouse Spermatozoa

    Michelle Krisfalusi;Kiyoshi Miki;Patricia L. Magyar;Deborah A. O'Brien

  • Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.

    Tomoya O. Akama;Hiroaki Nakagawa;Kazuhiro Sugihara;Sonoko Narisawa

  • Glyceraldehyde 3-phosphate dehydrogenase-S protein distribution during mouse spermatogenesis.

    Donna O'Dell Bunch;Jeffrey E. Welch;Patricia L. Magyar;E. M. Eddy

  • Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells.

    Jeffrey E. Welch;Paula L. Brown;Deborah A. O'brien;Patricia L. Magyar

  • Classification of mouse sperm motility patterns using an automated multiclass support vector machines model.

    Summer G. Goodson;Zhaojun Zhang;James K. Tsuruta;Wei Wang

  • Failure of spermatogenesis in mouse lines deficient in the Na+-K+- 2Cl- cotransporter

    Amy J. Pace;Eddie Lee;Krairek Athirakul;Thomas M. Coffman

  • Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells

    J E Welch;E C Schatte;D A O'Brien;D A O'Brien;E M Eddy

  • Expression of heat shock proteins by isolated mouse spermatogenic cells

    R L Allen;D A O'Brien;C C Jones;D L Rockett

  • A novel hsp70-like protein (P70) is present in mouse spermatogenic cells.

    R L Allen;D A O'Brien;E M Eddy

  • Metabolic Substrates Exhibit Differential Effects on Functional Parameters of Mouse Sperm Capacitation

    Summer G. Goodson;Yunping Qiu;Keith A. Sutton;Guoxiang Xie

Frequent Co-Authors

Edward M. Eddy
Edward M. Eddy National Institutes of Health
Fernando Pardo-Manuel de Villena
Fernando Pardo-Manuel de Villena University of North Carolina at Chapel Hill
Leonard McMillan
Leonard McMillan University of North Carolina at Chapel Hill
Elissa J. Chesler
Elissa J. Chesler University of Tennessee at Knoxville
Daniel Pomp
Daniel Pomp University of North Carolina at Chapel Hill
Kent W. Hunter
Kent W. Hunter National Institutes of Health
George M. Weinstock
George M. Weinstock The Jackson Laboratory
David W. Threadgill
David W. Threadgill Texas A&M University
Patrick F. Sullivan
Patrick F. Sullivan University of North Carolina at Chapel Hill
Gary A. Churchill
Gary A. Churchill The Jackson Laboratory

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