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Chemistry

D-Index
57
Citations
7578
World Ranking
11420
National Ranking
88

Overview

Chang-Yih Duh is affiliated with National Sun Yat-sen University in Taiwan and actively conducts research at the intersection of biochemistry, genetics, and molecular biology, as well as medicine. Their research contributions span multiple subfields including molecular biology, biotechnology, pharmacology, cancer research, and toxicology.

The core focus of their research lies in natural products derived from marine sponges and microbial sources, with particular emphasis on the synthesis and biological activity of bioactive compounds. Their work also addresses the molecular mechanisms involved in ubiquitin and proteasome pathways, cancer therapeutics, and genomics related to phytochemicals and oxidative stress.

Their recent scholarly articles reflect these research interests, including the following publications:

  • Scalarane-Type Sesterterpenoids from the Marine Sponge Lendenfeldia sp. Alleviate Inflammation in Human Neutrophils, 2021, Marine Drugs
  • Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents, 2020, Marine Drugs
  • Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldia sp., 2020, Marine Drugs
  • Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral Clavularia flava, 2020, Marine Drugs
  • Demethoxymurrapanine, an indole-naphthoquinone alkaloid, inhibits the proliferation of oral cancer cells without major side effects on normal cells, 2023, Environmental Toxicology

Chang-Yih Duh frequently publishes in the journal Marine Drugs, which has hosted the majority of their recent articles, along with contributions to Environmental Toxicology, The Cambridge Structural Database, and RSC Advances.

Collaboration plays a significant role in their work, with repeated partnerships involving several co-authors, including Bo-Rong Peng, Kuei-Hung Lai, Steve S.-F. Yu, Ping-Jyun Sung, and Jui-Hsin Su.

The scientific themes in their research cover:

  • Marine Sponges and Natural Products
  • Microbial Natural Products and Biosynthesis
  • Synthesis and Biological Activity
  • Bioactive Compounds and Antitumor Agents
  • Ubiquitin and proteasome pathways
  • Cancer therapeutics and mechanisms
  • Genomics, phytochemicals, and oxidative stress

Overall, Chang-Yih Duh contributes to the fundamental understanding of biologically active marine natural products and their therapeutic potential, integrating molecular biology and pharmacological perspectives into their research portfolio.

Best Publications

  • Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum.

    Ih-Sheng Chen;Chin-Teng Chang;Wine-Show Sheen;Che-Ming Teng

  • Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats.

    Yen Hsuan Jean;Wu Fu Chen;Chun Sung Sung;Chang Yih Duh

  • New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens.

    Ian Lih Tsai;Fan Pin Lee;Chin Chung Wu;Chang Yih Duh

  • New cytotoxic oxygenated fucosterols from the brown alga Turbinaria conoides.

    Jyh-Horng Sheu;Guey-Horng Wang;Ping-Jyun Sung;Chang-Yih Duh

  • Anti-inflammatory activities of natural products isolated from soft corals of Taiwan between 2008 and 2012.

    Wen Chi Wei;Ping-Jyun Sung;Chang-Yih Duh;Bo-Wei Chen

  • Two new natural azafluorene alkaloids and a cytotoxic aporphine alkaloid from Polyalthia longifolia.

    Yang Chang Wu;Chang Yih Duh;Shang Kwei Wang;Keh Shaw Chen

  • Sinugibberol, a new cytotoxic cembranoid diterpene from the soft coral Sinularia gibberosa.

    Rei-Sheu Hou;Chang-Yih Duh;Michael Y. Chiang;Chun-Nan Lin

  • Cytotoxic terpenoids from the Formosan soft coral Nephthea brassica.

    Chang-Yih Duh;Shang-Kwei Wang;Ying-Ling Weng;Michael Y. Chiang

  • Novel Cytotoxic Diterpenes, Excavatolides A−E, Isolated from the Formosan Gorgonian Briareum excavatum

    Jyh-Horng Sheu;Ping-Jyun Sung;Mou-Chih Cheng;Hsiao-Yu Liu

  • New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum.

    Jih-Jung Chen;Hui-Yu Fang;Chang-Yih Duh;Ih-Sheng Chen

  • Antiviral and Anti-inflammatory Metabolites from the Soft Coral Sinularia capillosa

    Shi-Yie Cheng;Ki-Jhih Huang;Shang-Kwei Wang;Zhi-Horng Wen

  • Cytotoxic pyridone alkaloids from the leaves of Piper aborescens.

    Chang Yih Duh;Yang-Chang Wu;Shang Kwei Wang

  • Cytotoxic sterols from the formosan brown alga Turbinaria ornata

    Jyh-Horng Sheu;Guey-Horng Wang;Ping-Jyun Sung;Yen-Hung Chiu

  • A novel cytotoxic norditerpenoid from the Formosan soft coral Sinularia inelegans

    Chang-Yih Duh;Shang-Kwei Wang;Min-Chi Chia;Michael Y. Chiang

  • Human cytomegalovirus UL76 induces chromosome aberrations.

    Voon-Kwan Siew;Chang-Yih Duh;Shang-Kwei Wang

  • Durumolides A–E, anti-inflammatory and antibacterial cembranolides from the soft coral Lobophytum durum

    Shi-Yie Cheng;Zhi-Hong Wen;Shu-Fen Chiou;Chi-Hsin Hsu

  • The Crystal Structure and Cytotoxicity of Goniodiol-7-monoacetate from Goniothalamus amuyon

    Yang-Chang Wu;Chang Yih Duh;Fang Rong Chang;Gwo Yuan Chang

  • Additional cytotoxic neolignans from Persea obovatifolia.

    Ian-Lih Tsai;Chih-Feng Hsieh;Chang-Yih Duh

  • Plant anticancer agents, XLII. Cytotoxic constituents from Wikstroemia elliptica.

    Chang-Yih Duh;C. H. Phoebe;J. M. Pezzuto;A. D. Kinghorn

  • The Preparation and Evaluation of 1-Substituted 1,2,3,4-Tetrahydro- and 3,4-Dihydro-β-carboline Derivatives as Potential Antitumor Agents

    Ya-Ching Shen;Ching-Yeu Chen;Pei-Wen Hsieh;Chang-Yih Duh

Frequent Co-Authors

Chang-Feng Dai
Chang-Feng Dai National Taiwan University
Jyh-Horng Sheu
Jyh-Horng Sheu National Sun Yat-sen University
Ih-Sheng Chen
Ih-Sheng Chen Kaohsiung Medical University
Yang Chang Wu
Yang Chang Wu China Medical University
Norman R. Farnsworth
Norman R. Farnsworth University of Illinois at Chicago
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Chin Chung Wu
Chin Chung Wu Kaohsiung Medical University
Tracy D. Wilkins
Tracy D. Wilkins Virginia Tech
Cheng-Wen Wu
Cheng-Wen Wu National Yang Ming University

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